IP Library Granted Patent US 12,661,144
Granted Patent B2
US 12,661,144 · App. 18/614,962 · Granted Jun 23, 2026

Atraumatically formed tissue compositions, devices and methods of preparation and treatment

Inventors: Thomas Andrew Davenport (Syosset, NY); Paul Mulhauser (New York, NY); Gregory C. Guinan (Brooklyn, NY)
Assignee: TissueMill Technologies LLC
A61B17/322A61L27/362A61L27/3695C12M45/02C12M45/04C12N5/0629A61B2017/3225
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Quick Facts
Patent No.
US 12,661,144
App. No.
18/614,962
Filed
Mar 25, 2024
Granted
Jun 23, 2026
Kind
B2
Art Unit
3771
USPC
606/132
Abstract

A process and system provides for atraumatic preparation of morselized Tissue Particles (TP)s, such as Full Thickness Skin Graft Particles (FTSGPs), cartilage particles and other organ tissue particles, in a liquid medium. The resultant tissue product may be a suspension of Tissue Particles in an aqueous solution and containing highly viable cells and may be rapidly prepared at bedside or in the operating room and conveniently delivered to a patient through a syringe or similar applicator. The morselized Tissues Particles may be used for surgical applications including wound healing, cosmetic surgery, and orthopedic cartilage repairs.

Claims (16)

1 . A process for wound healing treatment using autologous micrograft tissue comprising;

excising a tissue biopsy;

placing said biopsy and a sterile fluid in an aseptic container;

morselizing said biopsy into morsels in said container by repeated/umatically slicing said biopsy between a pair of cutting blades supported in juxtaposition while maintaining viability of the morsels;

separating said morsels from said fluid;

transferring said morsels to a dispenser; and

dispensing said morsels over a surface of said wound.

2 . A process of claim 1 further including draining said fluid from said container.

3 . A process of claim 1 further including a dispensing device removably attached to said container.

4 . A process of claim 3 , wherein said dispensing device is a syringe.

5 . A process of claim 2 further including an isolation chamber in communication between said container and said dispensing device.

6 . A process of claim 5 , wherein said isolation chamber includes an inlet and outlet for receiving and recirculating said morsels back into said container for further processing.

7 . A process of claim 6 , wherein said isolation chamber includes a filter.

8 . A process of claim 7 , wherein said filter is cylindrical.

9 . A process of claim 8 further including a piston plunger for positioning within said cylindrical filter for facilitating transfer of said morsels into said dispensing device.

10 . A process of claim 9 further including a channel in fluid communication with said dispensing device and said container and wherein said channel includes an openable valve.

Continuity (5)
Division 17236130 · Apr 21, 2021
Continuation 16584755 · Sep 26, 2019
Provisional Application 62844232 · May 7, 2019
Provisional Application 62843724 · May 6, 2019
Related Publication 20240225688A1 · Jul 11, 2024
References Cited (112)
US 2985389A · Willems · 1961 [cited by applicant]
US 3666187A · Norris · 1972 [cited by applicant]
US 4145008A · Wolford · 1979 [cited by applicant]
US 4681571A · Nehring · 1987 [cited by applicant]
US 5731199A · Roggero · 1998 [cited by applicant]
US 6824087B2 · McPherson et al. · 2004 [cited by applicant]
US 7270284B2 · Liao et al. · 2007 [cited by applicant]
US 7431230B2 · McPherson et al. · 2008 [cited by applicant]
US 7794449B2 · Shippert · 2010 [cited by applicant]
US 7980500B2 · Jenni et al. · 2011 [cited by applicant]
US 8109961B2 · Deshmukh · 2012 [cited by applicant]
US 8163549B2 · Yao et al. · 2012 [cited by applicant]
US 8286899B2 · Schowalter et al. · 2012 [cited by applicant]
US 8491497B2 · Houser et al. · 2013 [cited by applicant]
US 9296984B2 · Cimino et al. · 2016 [cited by applicant]
US 9909095B2 · Cimino et al. · 2018 [cited by applicant]
US 9987473B2 · Knowlton · 2018 [cited by applicant]
US 10076354B2 · Knowlton · 2018 [cited by applicant]
US 10080581B2 · Knowlton · 2018 [cited by applicant]
US 10125345B2 · Nash et al. · 2018 [cited by applicant]
US 10219827B2 · Knowlton · 2019 [cited by applicant]
US 10314640B2 · Knowlton · 2019 [cited by applicant]
US 10321948B2 · Knowlton · 2019 [cited by applicant]
US 10335190B2 · Knowlton · 2019 [cited by applicant]
US 10335191B2 · Knowlton · 2019 [cited by applicant]
US 10336980B2 · Cimino et al. · 2019 [cited by applicant]
US 10342574B2 · Knowlton · 2019 [cited by applicant]
US 10368904B2 · Knowlton · 2019 [cited by applicant]
US 10485575B2 · Knowlton · 2019 [cited by applicant]
US 10485606B2 · Knowlton · 2019 [cited by applicant]
US 10517635B2 · Knowlton · 2019 [cited by applicant]
US 10661063B2 · Knowlton · 2020 [cited by applicant]
US 10695546B2 · Knowlton · 2020 [cited by applicant]
US 10702684B2 · Knowlton · 2020 [cited by applicant]
US 10716924B2 · Knowlton · 2020 [cited by applicant]
US 10736653B2 · Knowlton · 2020 [cited by applicant]
US 20050139704A1 · Liao et al. · 2005 [cited by applicant]
US 20060111778A1 · Michalow · 2006 [cited by applicant]
US 20080089870A1 · Ghosh et al. · 2008 [cited by applicant]
US 20080153157A1 · Yao et al. · 2008 [cited by applicant]
US 20100003300A1 · Markland et al. · 2010 [cited by applicant]
US 20100015202A1 · Semler et al. · 2010 [cited by applicant]
US 20100152750A1 · Memar · 2010 [cited by applicant]
US 20110282238A1 · Houser et al. · 2011 [cited by applicant]
US 20130295673A1 · Taghizadeh et al. · 2013 [cited by applicant]
US 20130338792A1 · Schmieding et al. · 2013 [cited by applicant]
US 20140134212A1 · Shi et al. · 2014 [cited by applicant]
US 20160024450A1 · Quick et al. · 2016 [cited by applicant]
US 20160317170A1 · Knowlton · 2016 [cited by applicant]
US 20160374704A1 · Eriksson et al. · 2016 [cited by applicant]
US 20170224874A1 · Maki · 2017 [cited by examiner]
US 20170296214A1 · Knowlton · 2017 [cited by applicant]
US 20180000504A1 · Knowlton · 2018 [cited by applicant]
US 20180057787A1 · Friedman et al. · 2018 [cited by applicant]
US 20180236457A1 · Graziano et al. · 2018 [cited by applicant]
US 20180250027A1 · Knowlton · 2018 [cited by applicant]
US 20180250502A1 · Knowlton · 2018 [cited by applicant]
US 20180344340A1 · Knowlton · 2018 [cited by applicant]
US 20180344343A1 · Knowlton · 2018 [cited by applicant]
US 20180344344A1 · Knowlton · 2018 [cited by applicant]
US 20180344345A1 · Knowlton · 2018 [cited by applicant]
US 20180353202A1 · Knowlton · 2018 [cited by applicant]
US 20190002821A1 · Raviv · 2019 [cited by applicant]
US 20190054281A1 · Knowlton · 2019 [cited by applicant]
US 20190126020A1 · Knowlton · 2019 [cited by applicant]
US 20190134365A1 · Knowlton · 2019 [cited by applicant]
US 20190254693A1 · Knowlton · 2019 [cited by applicant]
US 20190307480A1 · Knowlton · 2019 [cited by applicant]
US 20220305174A1 · Awad et al. · 2022 [cited by applicant]
AU 2002229615B2 · 2006 [cited by applicant]
CN 2381279Y · 2000 [cited by applicant]
CN 1816280B · 2012 [cited by applicant]
CN 204281757U · 2015 [cited by applicant]
CN 104498350B · 2016 [cited by applicant]
CN 106244418A · 2016 [cited by applicant]
CN 106244437A · 2016 [cited by applicant]
CN 104887292B · 2017 [cited by applicant]
CN 108486043A · 2018 [cited by applicant]
CN 106085819B · 2019 [cited by applicant]
CN 106281991B · 2019 [cited by applicant]
CN 109790504A · 2019 [cited by applicant]
CN 105189729B · 2020 [cited by applicant]
EP 1161208A1 · 2001 [cited by applicant]
EP 1664276B1 · 2013 [cited by applicant]
EP 3378445A1 · 2018 [cited by applicant]
EP 3409369A1 · 2018 [cited by applicant]
EP 2945564B1 · 2019 [cited by applicant]
JP 2010178695A · 2010 [cited by applicant]
KR 101129419B1 · 2012 [cited by applicant]
WO 2012001607A1 · 2012 [cited by applicant]
WO 2015161057A1 · 2015 [cited by applicant]
WO 2015163010A1 · 2017 [cited by applicant]
WO 2018189431A1 · 2018 [cited by applicant]
WO 2019012231A1 · 2019 [cited by applicant]
WO 2019018002A1 · 2019 [cited by applicant]
WO 2025240760A1 · 2025 [cited by applicant]
Reveille Cartilage Processor Handling Technique—Oct. 30, 2013 Rev A, Exactech, 2016 available at: https://www.exac.com/product/reveille-handling-technique, 2 pages. [cited by applicant]
Reveille® Cartilage Processor, A cost-effective option for single stage surgery with autologous cartilage, Exactech, Mar. 18, 2020, available at: https://www.exac.com/biologics/reveille/, 3 pages. [cited by applicant]
Resource Library, Exactech, Mar. 18, 2020, available at: https://www.exac.com/resource-library/?fwp_brand_categories_dropdown=reveille-cartilage-processor, 1 page. [cited by applicant]
Biologics Main Brochure—713-00-20 Rev C, Exactech, Mar. 18, 2020, available at: https://www.exac.com/product/biologics-main-brochure, 9 pages. [cited by applicant]
PCT Invitation to Pay Additional Fees with Partial International Search, Application No. PCT/US2020/031286, Jul. 31, 2020, 13 pp. [cited by applicant]
Written Opinion, PCT Application No. 2021/027387, dated Jul. 9, 2021, 8 pages. [cited by applicant]
International Search Report, PCT Application No. 2021/027387, dated Jul. 9, 2021, 5 pages. [cited by applicant]
International Search Report, PCT Application No. 2020/031286, dated Sep. 23, 2020, 6 pages. [cited by applicant]
Written Opinion, PCT Application No. 2020/031286, dated Sep. 23, 2020, 10 pages. [cited by applicant]
Canadian Examination Report, CA Application No. 3,138,539, dated Jan. 18, 2022, 3 pages. [cited by applicant]
International Preliminary Report on Patentability, PCT Application No. 2020/031286, dated Nov. 2, 2021, 10 pages. [cited by applicant]
Intellectual Property Office of Singapore Written Opinion, Singapore Application No. 11202112159P, dated Sep. 19, 2022, 5 pages. [cited by applicant]
International Preliminary Report on Patentability, PCT Application No. 2021/027387, dated Nov. 8, 2022, 9 pages. [cited by applicant]
Office Action and Search Report in European Patent Application No. 20727112.3, mailed on Dec. 8, 2023. [cited by applicant]
Written Opinion, PCT Application No. PCT/US2025/029594, dated Aug. 7, 2025, 5 pages. [cited by applicant]
International Search Report, PCT Application No. PCT/US2025/029594, dated Aug. 7, 2025, 9 pages. [cited by applicant]