CURCUMIN AND TURMERONE COMPOSITIONS & METHODS OF USE THEREOF
Compositions that include concentrated amounts of curcumin II and/or curcumin III, along with concentrated amounts of turmerones, are disclosed. The compositions may be useful for increasing LDL receptor levels in a plurality of cells. In addition, the compositions may be useful for decreasing MSK1 levels in a plurality of cells. The compositions may also be used to increase expression of brain derived neurotrophic factor (BDNF) in a plurality of cells.
1 . A composition that comprises:
(a) a curcumin extract that is supplemented with additional curcumin II, curcumin III, or both curcumin II and curcumin III, such that the composition comprises at least 30% by weight curcumin II, at least 30% by weight curcumin III, or at least 30% by weight of a combination of curcumin II and curcumin III; and
(b) a turmerone composition, such that the composition comprises at least 5% by weight of turmerones.
2 . The composition of claim 1 , wherein the composition comprises at least 8% by weight of turmerones.
3 . The composition of claim 1 , wherein the composition comprises at least 10% by weight of turmerones.
4 . The composition of claim 1 , wherein the composition comprises at least 15% by weight of turmerones.
5 . The composition of claim 1 , wherein the composition comprises at least 20% by weight of turmerones.
6 . The composition of claim 1 , wherein the composition comprises at least 30% by weight of turmerones.
7 . The composition of claim 1 , wherein the composition comprises at least 40% by weight of turmerones.
8 . The composition of claim 1 , wherein the turmerone composition includes one or more turmerones selected from the group consisting of alpha-turmerone, beta-turmerone, and ar-turmerone.
9 . The composition of claim 1 , wherein the turmerone composition includes a mixture of alpha-turmerone, beta-turmerone, and ar-turmerone.
10 . The composition of claim 1 , wherein the composition is formulated as a capsule, pill, tablet, granule, solution or a suspension in an aqueous or non-aqueous liquid, oil-in-water or water-in-oil emulsion, elixir, syrup, paste, or dry powder.
11 . The composition of claim 10 , wherein the composition is formulated as the capsule, which further comprises hydroxypropyl methylcellulose, water, microcrystalline cellulose, magnesium stearate, and silicon dioxide.
12 . A method for increasing expression of brain derived neurotrophic factor (BDNF) in a plurality of cells, which comprises contacting the cells with an effective amount of the composition of claim 1 .
13 . A method for increasing expression of brain derived neurotrophic factor (BDNF) in a plurality of cells, which comprises contacting the cells with an effective amount of the composition of claim 2 .
14 . A method for increasing expression of brain derived neurotrophic factor (BDNF) in a plurality of cells, which comprises contacting the cells with an effective amount of the composition of claim 10 .
15 . A composition that comprises:
(a) a curcumin extract; and
(b) a turmerone composition, such that the composition comprises at least 5% by weight of turmerones.
16 . The composition of claim 15 , wherein the composition comprises at least 8% by weight of turmerones.
17 . The composition of claim 15 , wherein the composition comprises at least 10% by weight of turmerones.
18 . The composition of claim 15 , wherein the composition comprises at least 15% by weight of turmerones.