IP Library › Granted Patent US 12,251,529
Granted Patent B2
US 12,251,529 · App. 18/634,796 · Granted Mar 18, 2025

Devices with dimensions that can be reduced and increased in vivo, and methods of making and using the same

Inventors: Nir Nae (Binyamina, IL); Neal Eigler (Agoura Hills, CA); Nathan Bukhdruker (Haifa, IL); James S Whiting (Los Angeles, CA); Lior Rosen (Or Akiva, IL); Erez Rozenfeld (Shoham, IL); Werner Hafelfinger (Thousand Oaks, CA)
Assignee: V-Wave Ltd.
A61M27/002A61F2/90A61F2/95A61F2210/0023A61F2230/0069A61F2230/0078A61F2250/001A61F2250/0039A61M2205/0266A61M2210/125
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Quick Facts
Patent No.
US 12,251,529
App. No.
18/634,796
Granted
Mar 18, 2025
Kind
B2
Abstract

Devices are provided with an internal dimension that can be reduced and increased in vivo. In one example, an interatrial shunt for placement at an atrial septum of a patient's heart includes a body. The body includes first and second regions coupled in fluid communication by a neck region. The body includes a shape-memory material. The body defines a passageway through the neck region for blood to flow between a first atrium and a second atrium. The first and second regions are superelastic at body temperature, and the neck region is malleable at body temperature. A flow area of the passageway through the neck region may be adjusted in vivo.

Claims (27)

1. A method for adjusting a shunt anchored in a heart wall between a first heart chamber and a second heart chamber, the method comprising:

advancing a catheter to the shunt anchored in an opening of the heart wall, the shunt comprising a neck region between a first flared end region defining an inlet and a second flared end region defining an outlet, the shunt defining a lumen with an inner dimension to permit blood flow from the first heart chamber to the second heart chamber, the neck region heat treated to exhibit different shape memory properties than the first and second flared end regions such that the inner dimension of the lumen is adjustable in vivo, the shunt further defining an outer surface with an outer dimension in contact with the opening in the heart wall; and

heating, via the catheter, the shunt to change the inner dimension of the lumen,

wherein the inner dimension is changed independently of the outer dimension such that the outer dimension maintains contact with the opening in the heart wall when the inner dimension is changed.

2. The method of claim 1 , wherein the heating comprises heating a shape-memory material of the shunt to change the inner dimension of the lumen.

3. The method of claim 1 , wherein the shunt comprises an inner frame and an outer frame.

4. The method of claim 3 , wherein the inner frame is self-expanding superelastic NITINOL inner frame and the outer frame is a malleable shape-memory NITINOL outer frame.

5. The method of claim 3 , wherein the inner frame is a martensitic frame and the outer frame is an austenitic frame.

6. The method of claim 3 , wherein the inner and outer frames, when placed together, mechanically interfere with one another to remain co-registered.

7. The method of claim 3 , wherein a force required to expand the outer frame is greater than that produced by the inner frame such that the outer frame contains the inner frame.

8. The method of claim 3 , wherein there is no direct attachment between the inner and outer frames.

9. The method of claim 8 , wherein there is no direct mechanical coupling between the inner and outer frames.

10. The method of claim 8 , wherein the inner and outer frames are coupled in fluid communication.

11. The method of claim 1 , wherein the heart wall is an atrial septum, the first heart chamber is a first atrium, and the second heart chamber is a second atrium.

12. The method of claim 1 , wherein the shunt comprises a diabolo shape.

13. The method of claim 1 , wherein the neck region comprises a first material configured to change the inner dimension of the lumen responsive to the heating and a second material configured to maintain the outer dimension during the heating.

14. The method of claim 13 , wherein the first material comprises a martensitic frame and the second material comprises an austenitic frame.

15. The method of claim 1 , wherein the shunt comprises a first frame and a second frame.

16. The method of claim 15 , wherein the first and second frames are encapsulated with an encapsulant of expanded polytetrafluoroethylene (ePTFE) or other biocompatible material.

17. The method of claim 16 , wherein the encapsulant encapsulates both the first and second frames such that the first and second frames are indirectly and elastically coupled to one another.

18. The method of claim 1 , wherein the heating comprises flowing heated saline through the lumen via the catheter.

19. The method of claim 1 , wherein the heating comprises applying radio frequency (RF) energy.

20. The method of claim 1 , wherein the catheter comprises an expandable device.

21. The method of claim 20 , wherein the heating comprises heating via the expandable device while expanded.

22. The method of claim 1 , wherein changing the inner dimension of the shunt does not change the outer dimension.

23. The method of claim 1 , further comprising, before or after the heating, expanding the inner dimension of the lumen via mechanical expansion.

24. The method of claim 1 , wherein the heart wall is an atrial septum and wherein changing the inner dimension does not injure tissue grown around the outer surface of the shunt following septal wall puncture and implantation of the shunt at the atrial septum.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 17, 2024
From: NAE, NIR; EIGLER, NEAL; BUKHDRUKER, NATHAN; WHITING, JAMES S.; ROSEN, LIOR; ROZENFELD, EREZ; HAFELFINGER, WERNER
To: V-WAVE LTD.
Reel/Frame 067142/0053 →
Continuity (4)
Continuation 17092081 · Nov 6, 2020
Continuation 16875652 · May 15, 2020
Provisional Application 63019777 · May 4, 2020
Related Publication 20240261546A1 · Aug 8, 2024
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