IP Library › Granted Patent US 12,465,485
Granted Patent B2
US 12,465,485 · App. 17/490,510 · Granted Nov 11, 2025

Interatrial shunts having biodegradable material, and methods of making and using same

Inventors: Yaacov Nitzan (Hertzelia, IL); Menashe Yacoby (Ramat Gan, IL); Neal Eigler (Agoura Hills, CA); James S. Whiting (Los Angeles, CA); Erez Rozenfeld (Shoham, IL)
Assignee: V-Wave Ltd.
A61F2/2412A61B17/0057A61F2/2418A61F2/90A61B2017/00004A61B2017/00243A61B2017/00252A61B2017/00592A61B2017/00606A61B2017/00623A61F2/966A61F2210/0004A61F2230/001A61F2250/0039A61F2250/0067
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Quick Facts
Patent No.
US 12,465,485
App. No.
17/490,510
Granted
Nov 11, 2025
Kind
B2
Abstract

A device for regulating blood pressure between a patient's left atrium and right atrium comprises an hourglass-shaped stent comprising a neck region and first and second flared end regions, the neck region disposed between the first and second end regions and configured to engage the fossa ovalis of the patient's atrial septum, and a drug-eluting biodegradable material that biodegrades over time to release a drug that limits tissue overgrowth. The inventive device also may include a biodegradable material that biodegrades to offset flow changes caused by tissue overgrowth. The inventive device may reduce left atrial pressure and left ventricular end diastolic pressure, and may increase cardiac output, increase ejection fraction, relieve pulmonary congestion, and lower pulmonary artery pressure, among other benefits.

Claims (27)

1 . A device for regulating blood flow in a patient to treat a condition, the device comprising:

a stent comprising a first flared end region, a second flared end region, a neck region disposed between the first and second flared end regions, and a passageway extending through the first flared end region through the neck region and through the second flared end region, the stent configured to shunt blood between body cavities;

a biocompatible material disposed on the stent to define a sheath that channels blood flow through the passageway; and

a biodegradable material disposed on an inner surface of the biocompatible material at the neck region, the biodegradable material configured to carry a material that inhibits tissue overgrowth across the biodegradable material within the passageway of the stent.

2 . The device of claim 1 , wherein the stent comprises a plurality of rings interconnected by a plurality of longitudinally extending struts.

3 . The device of claim 1 , wherein the biocompatible material is disposed in the neck region, the second flared end region, and a portion of the first flared end region of the stent.

4 . The device of claim 1 , wherein the biocompatible material comprises ultra-high-molecular-weight-polyethylene (UHMWPE), expanded-polytetrafluoroethylene (ePTFE), polyurethane, DACRON (polyethylene terephthalate), silicone, polycarbonate urethane, or pericardial tissue from an equine, bovine, or porcine source, or any combination thereof.

5 . The device of claim 1 , wherein the biodegradable material defines a cross-sectional area of a blood flow path, and wherein the biodegradable material biodegrades after implantation to increase the cross-sectional area of the blood flow path.

6 . The device of claim 5 , wherein the biodegradable material is configured to biodegrade after implantation to increase the diameter of the blood flow path cross-sectional area at the neck region at least 1 mm over a period of time.

7 . The device of claim 5 , wherein the biodegradable material is configured to biodegrade upon exposure to an external stimulus.

8 . The device of claim 7 , wherein the external stimulus is heat.

9 . The device of claim 8 , wherein the device is configured to receive a delivery balloon configured to be positioning within the passageway and to receive a heated contrast-water mixture to transmit heat to the biodegradable material.

10 . The device of claim 7 , wherein the external stimulus is a biocompatible degradation activating material.

11 . The device of claim 7 , wherein the biodegradable material comprises a first biodegradable material layer configured to biodegrade responsive to application of a first external stimulus, and a second biodegradable material layer configured to biodegrade responsive to application of a second external stimulus different from the first external stimulus.

12 . The device of claim 1 , wherein the biodegradable material is further disposed on the biocompatible material adjacent to an inlet of the first flared end region or an outlet of the second flared end region, or both, to inhibit tissue overgrowth across the biodegradable material and into the passageway of the stent.

13 . The device of claim 1 , wherein the biodegradable material comprises at least one of collagen-terpolymer, polylactic acid (PLA), poly L-lactic acid (PLLA), polyglycolic acid (PGA), poly(lactic-co-glycolic) acid copolymer (PLGA), poly(ε-caprolactone), methacrylated dextran-aminoethyl methacrylate copolymer (Dex-MA/AEMA), polydiaxanone, poly(glycerol sebacate) (PGS), polysialic acid (PSA), collagen type I/III chitosan, or chitin, or any combination thereof.

14 . The device of claim 1 , wherein the first flared end region is configured to be disposed in a first atrium, the second flared end region is configured to be disposed in a second atrium, and the neck region is configured to be disposed at an atrial septum of the patient.

15 . The device of claim 1 , wherein the material comprises a drug deposited within the biodegradable material, the drug configured to inhibit tissue overgrowth, and wherein the biodegradable material is configured to biodegrade after implantation to release the drug such that tissue overgrowth is inhibited across the biodegradable material.

16 . The device of claim 15 , wherein the drug comprises an “-olimus” drug.

17 . The device of claim 15 , wherein the biocompatible material comprises a first biocompatible material layer and a second biocompatible material layer, and wherein the biodegradable material is sandwiched between the first and second biocompatible material layers, at least one of the first or second biocompatible material layers comprising a plurality of nodal pores sized and shaped to permit the drug to be released via the plurality of nodal pores as the biodegradable material biodegrades.

18 . The device of claim 15 , wherein the biodegradable material comprises a first biodegradable layer having a first concentration of the drug, and a second biodegradable layer having a second concentration of the drug, the second concentration of the drug different from the first concentration of the drug.

19 . A method of treating a subject with a condition, the method comprising:

providing a stent comprising a neck region between first and second flared end regions and a passageway extending through the first flared end region through the neck region and through the second flared end region, the stent further comprising a biocompatible material disposed on the stent and a biodegradable material disposed on an inner surface of the biocompatible material at the neck region;

shunting blood between the subject's body cavities through the passageway; and

inhibiting tissue overgrowth within the passageway of the stent using a material carried by the biodegradable material.

20 . The method of claim 19 , wherein the material comprises a drug deposited within the biodegradable material, the drug configured to inhibit tissue overgrowth, and wherein the inhibiting comprises biodegrading the biodegradable material to release the drug.

21 . The method of claim 19 , further comprising biodegrading the biodegradable material after implantation to increase a cross-sectional area at the neck region.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 30, 2021
From: NITZAN, YAACOV; YACOBY, MENASHE; EIGLER, NEAL; WHITING, JAMES S; ROZENFELD, EREZ
To: V-WAVE LTD.
Reel/Frame 057657/0977 →
Continuity (4)
Continuation 16395209 · Apr 25, 2019
Continuation In Part 15492852 · Apr 20, 2017
Continuation 13193309 · Jul 28, 2011
Related Publication 20220015897A1 · Jan 20, 2022
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