ANTIMICROBIAL COATING COMPOSITION AND METHOD OF USE THEREOF
A coating composition precursor comprising an antimicrobial agent, an esterification catalyst, and a chitosan conjugate, wherein the chitosan conjugate comprises a repeating unit of Formula I: or a conjugate salt thereof, wherein R 1 is —(C═O)(CH 2 )mCO 2 H, and m is a whole number selected from 1-12; a coating composition comprising the coating composition precursor, methods of use and products thereof.
1 . A coating composition precursor comprising:
an antimicrobial agent;
an esterification catalyst; and
a chitosan conjugate, wherein the chitosan conjugate comprises a repeating unit of Formula I,
or a conjugate salt thereof, wherein
R 1 is —(C═O)(CH 2 ) m CO 2 H; and
m is a whole number selected from 1-12.
2 . The coating composition precursor of claim 1 , wherein the antimicrobial agent is selected from the group consisting of biguanides comprising chlorhexidine salts, polyhexamethylene biguanide (PHMB), polyaminopropyl biguanide (PAPB), and a combination thereof.
3 . The coating composition precursor of claim 1 , wherein the esterification catalyst is selected from the group consisting of sodium bisulfate, potassium bisulfate, sodium hypophosphite, potassium hypophosphite, and a combination thereof.
4 . The coating composition precursor of claim 1 , wherein m is a whole number selected from 2-12.
5 . The coating composition precursor of claim 1 , wherein the antimicrobial agent is selected from the group consisting of biguanides comprising chlorhexidine salts, polyhexamethylene biguanide (PHMB), polyaminopropyl biguanide (PAPB), and a combination thereof; the esterification catalyst is selected from the group consisting of sodium bisulfate, potassium bisulfate, sodium hypophosphite, potassium hypophosphite, and a combination thereof; and m is a whole number selected from 2-12.
6 . The coating composition precursor of claim 1 , wherein the antimicrobial agent comprises chlorhexidine acetate or polyhexamethylene biguanide (PHMB); the esterification catalyst comprises sodium hypophosphite; and m is 4.
7 . The coating composition precursor of claim 1 , wherein the chitosan conjugate further comprises a repeating unit of Formula II and optionally a repeating unit of Formula III,
wherein the repeating unit of Formula I accounts for 6.67%-31.25% based on a total number of the repeating units of Formula I, repeating units of Formula II, and optionally the repeating units of Formula III in the chitosan conjugate.
8 . A coating composition comprising the coating composition precursor of claim 1 and at least one solvent.
9 . The coating composition of claim 8 , wherein the at least one solvent comprises water.
10 . The coating composition of claim 8 further comprising an additive, wherein the additive comprises a softener or cetyltrimethylammonium bromide.
11 . The coating composition of claim 10 , wherein the softener comprises a hydrophilic silicone softener.
12 . The coating composition of claim 10 comprising: about 0.01-0.2% by weight of the chitosan conjugate, about 0.1-5% of the antimicrobial agent by weight, about 1-10% of the softener by weight, about 0.01-0.1% of the cetyltrimethylammonium bromide by weight, about 0.01-0.1% of the esterification catalyst by weight, and about 84.6-98.7% of the at least one solvent by weight.
13 . The coating composition of claim 10 comprising: about 0.1% of the chitosan conjugate by weight, about 1% of the antimicrobial agent, by weight about 10% of the softener by weight, about 0.1% of the cetyltrimethylammonium bromide, and about 0.1% of the esterification catalyst by weight. and about 88.7% of the at least one solvent by weight, wherein the antimicrobial agent comprises a chlorhexidine acetate.
14 . The coating composition of claim 10 comprising: about 0.1% of the chitosan conjugate by weight, about 5% of the antimicrobial agent by weight, about 10% of the softener by weight, 0.1% of the cetyltrimethylammonium bromide by weight, and about 0.1% of the esterification catalyst by weight and about 84.7% of the at least one solvent by weight, wherein the antimicrobial agent comprises a polyhexamethylene biguanide.
15 . A coated textile comprising a textile and the coating composition precursor of claim 1 disposed on a surface of the textile.
16 . The coated textile of claim 15 , wherein at least a portion of the chitosan conjugate forms a covalent bond with the surface of the textile.
17 . The coated textile of claim 15 , wherein the coated textile exhibits at least 90% antimicrobial effect against one or more microbes selected from the group consisting of a bacteria, a virus, a combination thereof after 10 laundry cycles conducted in accordance with AATCC 61-2A or 50 home laundry cycles.
18 . A method of preparing a coated textile, the method comprising: contacting a textile with the coating composition of claim 8 thereby forming an uncured coated textile and curing the uncured coated textile thereby forming the coated textile.
19 . The method of claim 18 , wherein the curing step is conducted under conditions in which at least a portion of the chitosan conjugate forms a covalent bond with a surface of the textile.
20 . The method of claim 18 , wherein the textile comprises a cellulosic fiber.
21 . The method of claim 18 , wherein the curing comprises heating the uncured coated textile at 120° C. to 160° C.
22 . The method of claim 18 further comprising a pre-treatment step prior to the step of contacting the textile with the coating composition, wherein the pre-treatment step comprises: contacting the textile with sugar acid and sodium hypophosphite thereby forming an uncured pretreated textile, and curing the uncured pretreated textile under conditions in which at least a portion of the sugar acid forms a covalent bond with a surface of the textile.
23 . The method of claim 22 , wherein the textile comprises cotton and one or more of polyethylene terephthalate and spandex.