Optogenetic neural probe device with plurality of inputs and outputs and method of manufacturing the same
View Patent ↗An optogenetic neural probe device for transmitting an optical signal to a nerve cell or receiving a fluorescent signal from the nerve cell, including: an optical device alignment substrate; an optical device group on the optical device alignment substrate and including one or more optical devices; and one or more optogenetic neural probes, wherein each optogenetic neural probe from among the one or more optogenetic neural probes may include an optical neural probe substrate, an optical waveguide on the optical neural probe substrate, and an optical signal input/output port, wherein the optogenetic neural probe is configured to transmit the optical signal emitted from the optical device group to the optical signal input/output port through the optical waveguide.
1 . An optogenetic neural probe device comprising:
an optical device alignment substrate;
an optical device group on the optical device alignment substrate, the optical device group comprising one or more optical devices; and
one or more optogenetic neural probes, wherein each optogenetic neural probe from among the one or more optogenetic neural probes comprises an optical neural probe substrate, an optical waveguide on the optical neural probe substrate, and an optical signal input/output port,
wherein the optogenetic neural probe is configured to transmit an optical signal emitted from the optical device group to the optical signal input/output port through the optical waveguide,
wherein the optogenetic neural probe further comprises an optical mode size converter, the optical mode size converter being provided between at least one optical device of the optical device group and the optical waveguide, and
wherein a cross-sectional area of the optical mode size converter decreases in a direction from the at least one optical device toward the optical signal input/output port.
2 . The optogenetic neural probe device of claim 1 , wherein the optical device group comprises a first optical device and a second optical device, and
wherein a central wavelength characteristic of the first optical device is different from a central wavelength characteristic of the second optical device.
3 . The optogenetic neural probe device of claim 1 , wherein the optical device group comprises a first optical device and a second optical device, and
wherein the first optical device comprises a light emitting element, and the second optical device comprises a light receiving element.
4 . The optogenetic neural probe device of claim 1 , wherein the optical signal input/output port is configured to receive a fluorescent signal from a nerve cell, and to transmit the fluorescent signal to the optical waveguide, and
wherein the optical waveguide is configured to transmit the fluorescent signal to the optical device group.
5 . The optogenetic neural probe device of claim 1 , wherein the optical neural probe substrate is packaged on one side of the optical device alignment substrate.
6 . The optogenetic neural probe device of claim 5 , wherein the optical neural probe substrate directly contacts the optical device group at a portion of the optical neural probe substrate that is packaged on the optical device alignment substrate,
wherein the portion comprises a recess structure including a step, and
wherein a height of the step is equal to a height of the optical device group.
7 . The optogenetic neural probe device of claim 5 , wherein the optical device alignment substrate is coated with a fixing resin such that the optical neural probe substrate is fixed to the optical device alignment substrate.
8 . The optogenetic neural probe device of claim 7 , wherein the fixing resin comprises at least one from among a thermosetting resin and a photocurable resin.
9 . The optogenetic neural probe device of claim 1 , wherein the optogenetic neural probe comprises a plurality of shanks,
wherein each shank from among the plurality of shanks comprises a protrusion of the optical neural probe substrate, the optical waveguide, and the optical signal input/output port, and
wherein the plurality of shanks are spaced apart from each other at a predetermined interval.
10 . The optogenetic neural probe device of claim 9 , wherein at least one shank from among the plurality of shanks comprises a plurality of optical signal input/output ports on the optical waveguide included in the at least one shank.
11 . The optogenetic neural probe device of claim 9 , wherein at least one shank from among the plurality of shanks comprises a plurality of optical waveguides.
12 . The optogenetic neural probe device of claim 1 , wherein the optical signal input/output port is disposed at an end of the optical waveguide.
13 . The optogenetic neural probe device of claim 1 , wherein the optical signal input/output port comprises a diffraction grating.
14 . The optogenetic neural probe device of claim 1 , wherein the optical signal input/output port comprises a 45 degree mirror surface.
15 . The optogenetic neural probe device of claim 1 , wherein the optical device group comprises a plurality of optical device groups.
16 . The optogenetic neural probe device of claim 1 , wherein the optical mode size converter has one lens for each optical device, and a curvature of the one lens is determined by characteristics of a corresponding optical device.