Granted Patent
B2
US 12,281,336 · App. 18/675,059 · Granted Apr 22, 2025
Chikungunya virus (CHIKV) virus-like particles (VLPS) comprising the C, E1, and E2 structural proteins
Inventors:
Gary J. Nabel (Chestnut Hill, MA); Wataru Akahata (Kensington, MD); Srinivas Rao (Columbia, MD)
C12N7/00A61K39/12C12N7/045A61K2039/5258A61K2039/55566C12N2740/16043C12N2770/36123C12N2770/36134Y02A50/30
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Abstract
The invention features compositions and methods for the prevention or treatment of one or more strains of Chikungunya virus, as well as other alphavirus-mediated diseases.
Claims (5)
1. A kit comprising a virus-like particle (VLP) comprising CHIKV strain 37997 structural proteins, wherein the CHIKV strain 37997 structural proteins comprise at least CHIKV capsid (C) protein, CHIKV E2 protein, and CHIKV E1 protein, and wherein the VLP does not carry genetic information encoding the VLP proteins.
2. The kit of claim 1 , wherein the one or more structural proteins are selected from CHKV capsid (C) protein, CHKV E3 protein, CHKV E2 protein, CHKV 6K protein and CHKV E1 protein.
3. The kit of claim 1 , wherein the VLP comprises CHIKV envelope proteins E3, E2, 6K and E1.
4. The kit of claim 1 , wherein the VLP comprises CHIKV envelope proteins E1 and E2, and CHIKV capsid protein.
5. The kit of claim 1 , wherein the VLP comprises a polyprotein comprising C-E3-E2-6K-E1.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 28, 2024
From: NABEL, GARY J.; AKAHATA, WATARU; RAO, SRINIVAS S.
To: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Reel/Frame 067537/0355 →
Continuity (7)
Division
13131287
Provisional Application
61201118
· Dec 5, 2008
Provisional Application
61118206
· Nov 26, 2008
References Cited (50)
US 7947822B2
· Nabel et al.
· 2011
[cited by applicant]
US 9353353B2
· Nabel et al.
· 2016
[cited by applicant]
EP 1736538
· 2006
[cited by applicant]
WO WO2008026225
· 2008
[cited by applicant]
WO WO2008030220
· 2008
[cited by applicant]
WO WO2008030220A2
· 2008
[cited by examiner]
Akahata et al., “A VLP vaccine for epidemic Chikungunya virus protects nonhuman primates infection,”
[cited by applicant]
Akahata et al. “A Specific Domain of the Chikungunya Virus E2 Protein Regulates Particle Formation in Human Cells: Implications for Alphavirus Vaccine Design,”
[cited by applicant]
Chang et al., “Safety and Tolerability of Chikungunya Virus-Like Particle Vaccine in Healthy Adults: A Phase 1 Dose-Escalation Trial,”
[cited by applicant]
Gould et al., “Understanding the alphaviruses: Recent research on important emerging pathogens and progress towards their control,”
[cited by applicant]
Huang et al. “Generation of Synthetic Severe Acute Respiratory Syndrome Coronavirus Pseudoparticles: Implications for Assembly and Vaccine Production,”
[cited by applicant]
Intention to Grant for European Patent Application No. 098294 77 .0, dated Jan. 23, 2019, 5 pages.
[cited by applicant]
International Search Report for International Patent Application No. PCT/US09/06294, dated Oct. 19, 2010.
[cited by applicant]
Kim, Medical Molecular Virology, pp. 89-91, Science press, published on Feb. 2001 (evidence 1 cited in Official Action of related Chinese Patent Application No. 200980155476.X, dated Sep. 28, 2014, English translation o…
[cited by applicant]
Muthumani et al., “Immunogenicity of novel consensus-based DNA vaccines against Chikungunya virus,”
[cited by applicant]
Notice of Allowance for U.S. Appl. No. 15/145,483, dated Mar. 19, 2018, 12 pages.
[cited by applicant]
Notice of Reexamination with English Translation for China Patent Application No. 200980155476.X, dated Aug. 4, 2016, 15 pages.
[cited by applicant]
Official Action for Australian Patent Application No. 2009320287, dated Dec. 11, 2014, 3 pages.
[cited by applicant]
Official Action (with English translation) for Chinese Patent Application No. 200980155476.X, dated May 14, 201, 20 pages.
[cited by applicant]
Official Action (with English translation) for Chinese Patent Application No. 200980155476.X, dated Sep. 28, 2014, 20 pages.
[cited by applicant]
Official Action for European Patent Application No. 09829477.0, mailed Jun. 4, 2012, 6 pages.
[cited by applicant]
Official Action for European Patent Application No. 09829477.0, dated Mar. 9, 2015, 4 pages.
[cited by applicant]
Official Action for European Patent Application No. 098294 77 .0, dated Jul. 22, 2016, 5 pages.
[cited by applicant]
Official Action for European Patent Application No. 098294 77 .0, dated Sep. 28, 2017, 5 pages.
[cited by applicant]
Official Action for Malaysia Patent Application No. P12011002376, mailed May 15, 2015, 2 pages.
[cited by applicant]
Official Action for Malaysia Patent Application No. P1 2011002376, mailed Mar. 31, 2016, 2 pages.
[cited by applicant]
Official Action for Philippines Patent Application No. 1-2011-501012, mailed Jul. 25, 2014, 2 pages.
[cited by applicant]
Official Action for Philippines Patent Application No. 1-2011-501012, mailed Oct. 10, 2014, 2 pages.
[cited by applicant]
Official Action for Philippines Patent Application No. 1-2011-501012, mailed Jan. 22, 2015, 2 pages.
[cited by applicant]
Official Action for Philippines Patent Application No. 1/2011/501012, mailed Apr. 14, 2015, 2 pages.
[cited by applicant]
Official Action with English Translation for Vietnam Patent Application No. 1-2011-01662, dated Jun. 29, 2015, 2 pages.
[cited by applicant]
Official Action (Restriction Requirement) for U.S. Appl. No. 13/131,287, mailed Jun. 4, 2013, 7 pages.
[cited by applicant]
Official Action for U.S. Appl. No. 131,287, mailed Nov. 4, 2013.
[cited by applicant]
Official Action for U.S. Appl. No. 13/131,287, mailed May 8, 2014, 6 pages.
[cited by applicant]
Official Action for U.S. Appl. No. 13/131,287, mailed May 7, 2015, 13 pages.
[cited by applicant]
Official Action for U.S. Appl. No. 13/131,287, mailed Nov. 6, 2015, 12 pages.
[cited by applicant]
Official Action (Restriction Requirement) for U.S. Appl. No. 15/145,483, dated Sep. 25, 2017, 7 pages,.
[cited by applicant]
Official Action for U.S. Appl. No. 15/145,483, dated Apr. 24, 2018, 13 pages.
[cited by applicant]
Official Action for U.S. Appl. No. 15/145,483, dated Nov. 19, 2018, 10 pages.
[cited by applicant]
Official Action for European Patent Application No. 09829477.0, date Aug. 6, 2018, 3 pages.
[cited by applicant]
Pulmanausahakul et al., “Chikungunya in Southeast Asia: understanding the emergence and finding solutions,”
[cited by applicant]
Suhrbier et al., “Arthritogenic aphaviruses—an overview,”
[cited by applicant]
Tan, Therapeutic Immunology, Science press, pp. 459-461, Mar. 2007 (evidence 3 cited in Official Action of Chinese Patent Application No. 200980155476.X dated Sep. 28, 2014, English translation of lines 4-5 and 18-22 of…
[cited by applicant]
Thiboutot et al., “Chikungunya: A potentially emerging epidemic?”
[cited by applicant]
Wang et al., “Chimeric alphavirus vaccine candidates for chikungunya,”
[cited by applicant]
Wang et al., “Chimeric sindbis/eastern equine encephalitis vaccine candidates are highly attenuated and immunogenic in mice,”
[cited by applicant]
Weaver et al., “Chikungunya virus and prospects for a vaccine,”
[cited by applicant]
Weider, Science press, published on Jun. 2008, p. 234 (evidence 2 cited in Official Action of Chinese Patent Application No. 200980155476.X Sep. 28, 2014, English translation of text from p. 234), 1 page.
[cited by applicant]