IP Library › Granted Patent US 12,390,187
Granted Patent B2
US 12,390,187 · App. 18/675,500 · Granted Aug 19, 2025

Measurement device

Inventors: Alaina Ann Brinley Rajagopal (Pasadena, CA); Aditya Rajagopal (Pasadena, CA)
Assignee: California Institute of Technology
A61B8/0891A61B8/14A61B8/40A61B8/4236A61B8/4472G01S15/895
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,390,187
App. No.
18/675,500
Granted
Aug 19, 2025
Kind
B2
Abstract

A measurement device includes: a processing device and multiple sensors that capture tomographic information of a physiological structure. The sensors include a first sensor including a first transducer having a first frequency response with a first resonant frequency, and a second sensor including a second transducer having a second frequency response with a second resonant frequency different from the first resonant frequency. The first frequency response partially overlaps with the second frequency response. The second transducer transmits a signal that is reflected by the physiological structure to create a reflected signal, the first transducer generates a first received signal from the reflected signal, the second transducer generates a second received signal from the reflected signal, and the processing device normalizes the first received signal with the second received signal or the second received signal with the first received signal.

Claims (53)

1. A measurement device, comprising:

a processing device; and

a plurality of sensors configured to capture tomographic information of a physiological structure, the plurality of sensors comprising a first sensor including a first transducer having a first frequency response with a first resonant frequency, and a second sensor including a second transducer having a second frequency response with a second resonant frequency different from the first resonant frequency, wherein:

the first frequency response partially overlaps with the second frequency response;

the second transducer is configured to transmit a signal that is reflected by the physiological structure to create a reflected signal;

the first transducer is configured to generate a first received signal from the reflected signal;

the second transducer is configured to generate a second received signal from the reflected signal; and

the processing device is configured to normalize the first received signal with the second received signal or the second received signal with the first received signal.

2. The measurement device of claim 1 , wherein the first frequency response does not include the second resonant frequency, and the second frequency response does not include the first resonant frequency.

3. The measurement device of claim 1 , wherein:

the plurality of sensors further comprise a third sensor including a third transducer having a third frequency response with a third resonant frequency different from the first resonant frequency and the second resonant frequency;

the third frequency response partially overlaps with the second frequency response but not the first frequency response; and

the third transducer is configured to generate a third received signal from the reflected signal.

4. The measurement device of claim 3 , wherein the processing device is further configured to: correlate the third received signal with the second received signal.

5. The measurement device of claim 3 , wherein: the third frequency response does not include the second resonant frequency, and the second frequency response does not include the third resonant frequency.

6. The measurement device of claim 1 , wherein during capture of the tomographic information of the physiological structure, the first transducer and the second transducer are configured to be actuated in a time-interleaved fashion to capture images of a surface of the physiological structure at a plurality of depths.

7. The measurement device of claim 1 , wherein:

the physiological structure comprises an artery; and

the processing device is further configured to use the plurality of sensors to compute a mean arterial pressure through the artery.

8. The measurement device of claim 7 , wherein the processing device is configured to use the plurality of sensors to compute the mean arterial pressure through the artery by performing operations comprising:

measuring, using the plurality of sensors, a circumference of the artery,

measuring, using the plurality of sensors, a blood flow velocity; and

computing, using the circumference of the artery and the blood flow velocity, the mean arterial pressure.

9. The measurement device of claim 8 , wherein measuring the circumference of the artery comprises: measuring, with the plurality of sensors, using echo-mode ultrasonography, the circumference of the artery.

10. The measurement device of claim 8 , wherein measuring the blood flow velocity comprises: measuring, with the plurality of sensors, using continuous-wave, the blood flow velocity.

11. The measurement device of claim 7 , further comprising: a substrate incorporating the plurality of sensors, the substrate including an adhesive surface for adhering to skin of a person.

12. The measurement device of claim 11 , further comprising: a wireless transmitter incorporated in the substrate, the wireless transmitter configured to transmit the mean arterial pressure to a wireless receiver of a display system.

13. The measurement device of claim 7 , wherein the processing device is configured to use the plurality of sensors to iteratively recompute the mean arterial pressure through the artery.

14. The measurement device of claim 13 , further comprising: a display that dynamically displays the mean arterial pressure as it is iteratively recomputed.

15. A method, comprising:

capturing, using a plurality of sensors of a measurement device, tomographic information of a physiological structure, wherein the plurality of sensors comprise a first sensor including a first transducer having a first frequency response with a first resonant frequency, and a second sensor including a second transducer having a second frequency response with a second resonant frequency different from the first resonant frequency, the first frequency response partially overlapping with the second frequency response;

transmitting, using the second transducer, a signal that is reflected by the physiological structure to create a reflected signal;

generating, using the first transducer, a first received signal from the reflected signal;

generating, using the second transducer, a second received signal from the reflected signal; and

normalizing the first received signal with the second received signal or the second received signal with the first received signal.

16. The method of claim 15 , wherein:

the plurality of sensors further comprise a third sensor including a third transducer;

the third transducer has a third frequency response with a third resonant frequency different from the first resonant frequency and the second resonant frequency;

the third frequency response partially overlaps with the second frequency response but not the first frequency response; and

the method further comprises:

generating, using the third transducer, a third received signal from the reflected signal; and

correlating the third received signal with the second received signal.

17. The method of claim 16 , wherein the first frequency response does not include the second resonant frequency, the second frequency response does not include the first resonant frequency or the third resonant frequency, and the third frequency response does not include the second resonant frequency.

18. The method of claim 15 , wherein:

the physiological structure comprises an artery of a person;

the measurement device is incorporated in a substrate having an adhesive surface; and

the method further comprises:

aligning the substrate with the artery, and

after aligning the substrate, adhering the adhesive surface of the substrate to the person.

19. The method of claim 18 , further comprising:

iteratively recomputing, using the plurality of sensors, a mean arterial pressure through the artery; and

wirelessly transmitting, using a wireless transmitter incorporated in the substrate, the mean arterial pressure to a wireless receiver of a display system; and

dynamically displaying, using the display system, the mean arterial pressure as it is iteratively recomputed.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 28, 2024
From: RAJAGOPAL, ALAINA ANN BRINLEY; RAJAGOPAL, ADITYA
To: CALIFORNIA INSTITUTE OF TECHNOLOGY
Reel/Frame 067539/0359 →
Continuity (4)
Continuation 18128998 · Mar 30, 2023
Continuation 16547544 · Aug 21, 2019
Provisional Application 62720405 · Aug 21, 2018
Related Publication 20240307026A1 · Sep 19, 2024
References Cited (36)
US 5070734A · Kawabuchi et al. · 1991 [cited by applicant]
US 5800359A · Medero et al. · 1998 [cited by applicant]
US 6176832B1 · Habu et al. · 2001 [cited by applicant]
US 7437947B1 · Shen et al. · 2008 [cited by applicant]
US 8657755B2 · Parfenov et al. · 2014 [cited by applicant]
US 9250251B2 · Nicolaides et al. · 2016 [cited by applicant]
US 9603533B2 · Lading et al. · 2017 [cited by applicant]
US 11103211B2 · Liu et al. · 2021 [cited by applicant]
US 12102477B2 · Brinley Rajagopal · 2024 [cited by examiner]
US 20040116813A1 · Selzer et al. · 2004 [cited by applicant]
US 20060079773A1 · Mourad et al. · 2006 [cited by applicant]
US 20110137173A1 · Lowe et al. · 2011 [cited by applicant]
US 20130303923A1 · Lerner et al. · 2013 [cited by applicant]
US 20140276062A1 · Kondoh · 2014 [cited by applicant]
US 20160345930A1 · Mizukami et al. · 2016 [cited by applicant]
US 20170360397A1 · Rothberg et al. · 2017 [cited by applicant]
CN 1980687A · 2007 [cited by applicant]
CN 101150989A · 2008 [cited by applicant]
CN 102481103A · 2012 [cited by applicant]
CN 103385703A · 2013 [cited by applicant]
CN 103648374A · 2014 [cited by applicant]
CN 104010566A · 2014 [cited by applicant]
CN 104749384A · 2015 [cited by applicant]
CN 105580049A · 2016 [cited by applicant]
CN 109414222A · 2019 [cited by applicant]
WO 0243564A2 · 2002 [cited by applicant]
WO 2014066859A1 · 2014 [cited by applicant]
WO 2014155265A1 · 2014 [cited by applicant]
First Office Action and Search Report dated Dec. 13, 2023, issued in related Chinese Application No. 201980054869.5, with English machine translation (20 pages). [cited by applicant]
Yaqin Xiong et al., “Study on the Application of Color Doppler Ultrasound-Guided Aortic Balloon Occlusion in Pelvic and Sacrococcygeal Tumor Surgery”, Journal of Sichuan University (Medical Science Edition), 43(5), May … [cited by applicant]
Xiaojie Xie et al., “Abnormal Pregnancy”, Chinese Medical Abstracts: Family Planning and Obstetrics and Gynecology, Third Issue, Mar. 31, 1999, pp. 144-158, with English machine translation. [cited by applicant]
Wufeng Huang et al., “Effect of Microbubble Cavitation on Microcirculation in Skeletal Muscles of Rats”, Journal of Southern Medical University, 2006 (12), Dec. 31, 2006, pp. 1690-1693, with English language abstract. [cited by applicant]
PCT International Search Report and the Written Opinion mailed Nov. 12, 2019, issued in related International Application No. PCT/US2019/047593 (11 pages). [cited by applicant]
PCT International Preliminary Report on Patentability mailed Mar. 4, 2021, issued in related International Application No. PCT/US2019/047593 (7 pages). [cited by applicant]
Notice of Allowance and Search Report dated May 17, 2024, issued in related Chinese Application No. 201980054869.5, with English machine translation (7 pages). [cited by applicant]
Naibin Ll et al., “Video-Assisted Thoracoscopic Surgery for the Treatment of Patent Ductus Arteriosus: A Report of 16 Cases”, Chin J Clin Thorac Cardiovasc Surg., vol. 12, No. 2, Apr. 2005, pp. 127-128, with English lan… [cited by applicant]