N,N-DIMETHYLTRYPTAMINE (DMT) CRYSTALLINE PRODUCTS AND METHODS OF MAKING THE SAME
An effective and efficient process for obtaining a crystalline products comprised of salts of N,N-Dimethyltryptamine (DMT) freebase is provided. The crystalline products may, for example, be DMT fumarate, DMT tartrate, DMT succinate, or DMT maleate.
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19 . Crystalline N,N-dimethyltryptamine (DMT) fumarate, wherein the DMT fumarate is characterized by at least one of:
(A) unit cell dimensions of
a=7.7447(3) Å,
b=9.3258(4) Å,
c=12.4691(4) Å,
α=102.798(2)°,
β=104.869(2)°, and
γ=103.270(2)°,
at a temperature of about 298° K;
(B) a triclinic crystal system and a P-1 space group at a temperature of about 298° K; and
(C) an x-ray powder diffraction pattern with peaks at 20.5 and 25.0° 2θ±0.2° 2θ.
20 . The crystalline N,N-dimethyltryptamine (DMT) fumarate of claim 19 , wherein the DMT fumarate is characterized by at least two of:
(A) unit cell dimensions of
a=7.7447(3) Å,
b=9.3258(4) Å,
c=12.4691(4) Å,
α=102.798(2)°,
β=104.869(2)°, and
γ=103.270(2)°,
at a temperature of about 298° K;
(B) a triclinic crystal system and a P-1 space group at a temperature of about 298° K; and
(C) an x-ray powder diffraction pattern with peaks at 20.5 and 25.0° 2θ±0.2° 2θ.
21 . The crystalline N,N-dimethyltryptamine (DMT) fumarate of claim 20 , wherein the DMT fumarate is characterized by all three of:
(A) unit cell dimensions of
a=7.7447(3) Å,
b=9.3258(4) Å,
c=12.4691(4) Å,
α=102.798(2)°,
β=104.869(2)°, and
γ=103.270(2)°,
at a temperature of about 298° K;
(B) a triclinic crystal system and a P-1 space group at a temperature of about 298° K; and
(C) an x-ray powder diffraction pattern with peaks at 20.5 and 25.0° 2θ±0.2° 2θ.
22 . Crystalline N,N-dimethyltryptamine (DMT) tartrate, wherein the DMT tartrate forms a unit cell in which there is a ratio of DMT:tartrate of about 1:3 to 1:1.5.
23 . The DMT tartrate of claim 22 , wherein the ratio of DMT:tartrate is about 1:2.
24 . Crystalline N,N-dimethyltryptamine (DMT) tartrate, wherein the DMT tartrate is characterized by one or both of one of:
(A) unit cell dimensions of
a=7.57270(10) Å,
b=9.52180(10) Å,
c=23.7834(4) Å,
α=90°,
β=90.6530(10)°, and
γ=90°,
at a temperature of about 297° K; and
(B) a monoclinic crystal system and a P2 1 /n space group at a temperature of about 298° K.
25 . The crystalline N,N-dimethyltryptamine (DMT) tartrate of claim 24 , wherein the DMT tartrate is characterized by both of:
(A) unit cell dimensions of
a=7.57270(10) Å,
b=9.52180(10) Å,
c=23.7834(4) Å,
α=90°,
β=90.6530 (10)°, and
γ=90°,
at a temperature of about 297° K; and
(B) a monoclinic crystal system and a P2 1 /n space group at a temperature of about 298° K.
26 . The crystalline N,N-dimethyltryptamine (DMT) fumarate of claim 20 , wherein the DMT fumarate is characterized by both of:
(A) unit cell dimensions of
a=7.7447(3) Å,
b=9.3258(4) Å,
c=12.4691(4) Å,
α=102.798(2)°,
β=104.869(2)°, and
γ=103.270(2)°,
at a temperature of about 298° K; and
(B) a triclinic crystal system and a P-1 space group at a temperature of about 298° K.
27 . The crystalline N,N-dimethyltryptamine (DMT) fumarate of claim 20 , wherein the DMT fumarate is characterized by both of:
(A) unit cell dimensions of
a=7.7447(3) Å,
b=9.3258(4) Å,
c=12.4691(4) Å,
α=102.798(2)°,
β=104.869(2)°, and
γ=103.270(2)°,
at a temperature of about 298° K; and
(B) an x-ray powder diffraction pattern with peaks at 20.5 and 25.0° 2θ±0.2° 2θ.
28 . The crystalline N,N-dimethyltryptamine (DMT) fumarate of claim 20 , wherein the DMT fumarate is characterized by both of:
(A) a triclinic crystal system and a P-1 space group at a temperature of about 298° K; and
(B) an x-ray powder diffraction pattern with peaks at 20.5 and 25.0° 2θ±0.2° 2θ.