COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING HAIR LOSS
Described herein are compositions for promoting hair growth and/or treating or preventing hair loss in a mammalian subject. In certain embodiments, the mammalian subject is a human male or a human female. Methods of making and using the same are also described. The compositions in various embodiments may comprise: a tea extract which may comprise a polyphenol, e.g., epigallocatechin gallate; an extract from Larix europaea which may comprise the flavonoid taxifolin; a natural ingredient that antagonizes or mitigates the proliferation of Gram-positive bacteria in the hair shaft passageway; compounds including zinc chloride and/or hexamidine diisethionate; follicle stimulator. e.g., caffeine, an ingredient that improves the health of the dermis. e.g., sodium hyaluronate; and/or ingredients specifically tailored for male or female subjects, e.g., Serenoa serrulata fruit extract or extract of Pterocarpus marsupium.
1 - 46 . (canceled)
47 . A hair care composition comprising:
an androgen balancing agent;
a prostaglandin balancing agent;
an antimicrobial agent;
an anti-inflammatory agent;
a collagen modulator;
a circulation enhancer;
an amino acid; and
a cosmetically acceptable carrier.
48 . The hair care composition according to claim 47 , wherein the androgen balancing agent is selected from an extract or derivative of: Ganoderma lucidum (Reishi); Glycyrrhiza glabra (Licorice); Paeonia lactiflora (White Peony); Camellia sinensis (Green Tea); Mentha spicata (Spearmint); Actaea racemose (Black Cohosh); Vitex agnus - castus (Chaste Tree); Serenoa repens (Saw Palmetto); and a combination of two or more thereof.
49 . The hair care composition according to claim 47 , wherein the antimicrobial comprises an antibacterial agent or an antifungal agent.
50 . The hair care composition according to claim 47 , wherein the antimicrobial agent is selected from: a zinc ion source (e.g., zinc chloride or zinc gluconate); Glycyrrhiza uralensis (Licorice) root extract; hexamidine diisethionate; Saccharomyces /copper ferment; Saccharomyces /zinc ferment; ketonconazole; and a combination of two or more thereof.
51 . The hair care composition according to claim 47 , wherein the anti-inflammatory agent is selected from: Larix europaea wood extract (e.g., taxifolin or DHQG); Aesculus hippocastanum (Horse Chestnut) seed extract; Phellinus linteus (mushroom) extract; apigenin; oleanolic acid; Aloe barbadensis leaf extract; Houttuynia cordata extract; and a combination of two or more thereof.
52 . The hair care composition according to claim 47 , wherein the collagen modulator comprises hyaluronic acid, or a salt thereof.
53 . The hair care composition according to claim 47 , further comprising a penetration enhancer; wherein the penetration enhancer is selected from: peppermint oil; isopropyl myristate; a ceramide; lecithin; a liposome; and a combination of two or more thereof.
54 . The hair care composition according to claim 47 , wherein the hair care composition is selected from: a lotion; a serum; a tincture; a cream; an ointment; a gel; a powder; and a balm.
55 . The hair care composition according to claim 47 , wherein the circulation enhancer comprises a vasodilator; wherein the vasodilator is selected from: caffeine; cocoa; coenzyme Q10 (CoQ10); a source of Allium sativum ; arginine; magnesium; niacin (vitamin B3); a nitrate source; Petroselinum crispum; Zingiber officinale ; and a combination of two or more thereof.
56 . The hair care composition according to claim 47 , further comprising a peptide selected from: copper-tripeptie-1; glycyl-L-histidyl-L-lysine; palmitoyl tripeptide-1; biotinoyl tripeptide-1; and a combination of two or more thereof.
57 . The hair care composition according to claim 47 , wherein the amino acid is selected from: glutamic acid; methionine; cysteine; homocysteine; taurine; and a combination of two or more thereof.
58 . The hair care composition according to claim 47 , further comprising soy isoflavones.
59 . The hair care composition according to claim 47 , wherein the cosmetically acceptable carrier comprises:
from about 50 wt. % to about 80 wt. % water;
from about 5 wt. % to about 20 wt. % of a monohydric alcohol; and
from about 1 wt. % to about 15 wt. % of a diol.
60 . A composition for promoting hair growth and/or reducing hair loss comprising:
a copper ion source;
an extract or derivative of Camellia sinensis;
an extract or derivative of Serenoa serrulate;
a natural vasodilator; and
a peptide selected from: copper-tripeptie-1; glycyl-L-histidyl-L-lysine; palmitoyl tripeptide-1; biotinoyl tripeptide-1; and a combination of two or more thereof.
61 . A composition for promoting hair growth and/or reducing hair loss comprising:
a copper ion source;
an extract or derivative of Camellia sinensis;
soy isoflavones; and
a natural vasodilator.
62 . A method for promoting hair growth and reducing hair loss comprising: administering an effective amount of a hair care composition according to claim 47 , to a skin surface of a subject in need thereof.
63 . The method according to claim 62 , wherein the hair care composition is administered from a dispenser comprising an applicator; wherein the applicator comprises a perforated surface.
64 . The method according to claim 62 , wherein the hair care composition has a viscosity adapted to be delivered through said perforated surface of said applicator.
65 . The method according to claim 62 , wherein the administration of the hair care composition increases aggregation of intradermal adipocytes on the scalp of a mammalian subject; and wherein the increased aggregation of intradermal adipocytes results in a yellowing of the scalp.
66 . The method according to claim 62 , wherein the hair care composition increases the GRO Index by at least about 10.