Heteroaryl derivative compounds, and uses thereof
The present disclosure relates to a heteroaryl derivative and uses thereof. The heteroaryl derivative of the present disclosure exhibits excellent inhibitory activity against EGFR and/or HER2, and thus may be usefully employed as a therapeutic agent for EGFR- and/or HER2-related diseases.
1 . A compound represented by the following Chemical Formula 1B, an optical isomer thereof, or a pharmaceutically acceptable salt thereof:
wherein
Y is phenyl in which at least one H of the phenyl ring may be substituted with -halo, L is —(CH 2 ) m —, or null,
m is 0 or 1,
a ring Z is phenyl or 5- to 6-membered heteroaryl in which at least one H of the phenyl or 5- to 6-membered heteroaryl ring may be substituted with —C 1-3 alkyl, —C 1-3 haloalkyl, —C 1-3 alkenyl, —O—C 1-3 alkyl, —O—C 1-3 haloalkyl, —C(═O)—C 1-3 alkyl, -halo, or Z 1 , wherein at least one H of the phenyl in the meta position relative to the L is unsubstituted or substituted with at least one selected from the group consisting of —C 1-3 alkyl, —C 1-3 alkenyl, —O—C 1-3 alkyl, —O—C 1-3 haloalkyl, —C(═O)—C 1-3 alkyl, -halo, and Z 1 when the ring Z is phenyl,
Z 1 is 3- to 7-membered cycloalkyl, 5- to 7-membered heterocycloalkyl, or heteroaryl in which the 5- to 7-membered heterocycloalkyl contains, in the ring, at least one selected from the group consisting of N and O, and at least one H of the 5- to 7-membered heterocycloalkyl or heteroaryl ring may be substituted with —C 1-3 alkyl, —N(C 1-3 alkyl) (C 1-3 alkyl), or Z 2 ,
Z 2 is 5- to 7-membered heterocycloalkyl or 6- to 10-membered heterobicycloalkyl in which the 5- to 7-membered heterocycloalkyl or 6- to 10-membered heterobicycloalkyl contains, in the ring, at least one selected from the group consisting of N and O, and at least one H of the 5- to 7-membered heterocycloalkyl or 6- to 10-membered heterobicycloalkyl ring may be substituted with —C 1-6 alkyl, —C 1-3 hydroxyalkyl, —C 1-3 alkenyl, —C 1-3 alkyl-S(═O) 2 —C 1-3 alkyl, ═O, 3- to 7-membered cycloalkyl, or Z 3 , and
Z 3 is 4- to 6-membered heterocycloalkyl or —C 1-3 alkyl-heterocycloalkyl in which the 4- to 6-membered heterocycloalkyl or —C 1-3 alkyl-heterocycloalkyl contains, in the ring, at least one selected from the group consisting of N and O.
2 . A compound, an optical isomer thereof, or a pharmaceutically acceptable salt thereof selected from the group consisting of the following compounds:
3 . The compound, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of claim 2 selected from the group consisting of the following compounds:
4 . The compound, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of claim 2 selected from the group consisting of the following compounds:
5 . The compound, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of claim 2 selected from the group consisting of the following compounds:
6 . The compound, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of claim 2 selected from the group consisting of the following compounds:
7 . The compound, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of claim 2 selected from the group consisting of the following compounds:
8 . The compound, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of claim 2 selected from the group consisting of the following compounds:
9 . The compound, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of claim 2 selected from the group consisting of the following compounds:
10 . The compound, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of claim 2 selected from the group consisting of the following compounds:
11 . The compound, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of claim 2 selected from the group consisting of the following compounds:
12 . The compound, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of claim 2 selected from the group consisting of the following compounds:
13 . The compound, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of claim 2 selected from the group consisting of the following compounds:
14 . The compound, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of claim 2 selected from the group consisting of the following compounds:
15 . The compound, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of claim 2 selected from the group consisting of the following compounds:
16 . The compound, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of claim 2 selected from the group consisting of the following compounds:
17 . The compound, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of claim 2 having the formula
18 . The compound, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of claim 2 having the formula
19 . The compound, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of claim 2 having the formula
20 . The compound, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of claim 2 having the formula