IP Library Granted Patent US 12,502,195
Granted Patent B2
US 12,502,195 · App. 18/752,516 · Granted Dec 23, 2025

Apparatus to treat tissue with pulsatile shear waves

Inventors: Nikolai Aljuri (Hillsborough, CA); Edward Karpman (Los Altos, CA); Chris Danek (San Carlos, CA)
Assignee: PROCEPT BioRobotics Corporation
A61B17/3203A61B2017/00154A61B2017/00172A61B2017/00274A61B2017/32032A61B2017/32035A61B2018/00547
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Quick Facts
Patent No.
US 12,502,195
App. No.
18/752,516
Granted
Dec 23, 2025
Kind
B2
Abstract

An apparatus is configured to provide hemostasis with tissue removal in order to inhibit one or more of blood loss or tissue drainage. In many embodiments, a nozzle releases a liquid jet in a liquid medium in order to provide cavitation and a plurality of shedding pulses. The liquid jet, its cavitation and the plurality of shedding pulses can affect vascular tissue in order to promote clotting in order to inhibit bleeding. In many embodiments, vessels of the vascular tissue are affected at a distance from a region where cavitation of the water jet contacts the tissue. In many embodiments, the cavitation and plurality of shedding pules are related to a pulsatile shear wave propagating along the blood vessel that is related to clot promoting changes of the blood vessel.

Claims (16)

1 . An apparatus to treat tissue, the apparatus comprising,

a pump;

a nozzle coupled to the pump, the nozzle sized for immersion in a liquid and configured to generate a plurality of pulsatile shear waves to treat the tissue; and

a circuitry coupled to the pump and configured to control fluid flow through the nozzle to treat the tissue with the plurality of pulsatile shear waves.

2 . The apparatus of claim 1 , wherein the pump provides a flow rate through the nozzle and the nozzle is configured to provide the plurality of pulsatile shear waves to a cut profile at a distance from the nozzle.

3 . The apparatus of claim 1 , wherein the nozzle is configured to be arranged with the tissue at a distance no more than a threshold transition distance from the tissue.

4 . The apparatus of claim 1 , wherein the nozzle is configured to be arranged with the tissue at a distance greater than a threshold transition distance from the tissue.

5 . The apparatus of claim 1 , wherein the circuitry comprises a processor configured to treat the tissue with the nozzle, wherein the processor is configured to cause removal of the tissue according to a tissue removal profile with the nozzle positioned at a distance no more than a threshold transition distance for selective tissue removal from a tissue removal profile.

6 . The apparatus of claim 2 , wherein the pump comprises a piston configured to deliver a plurality of pump pulses and wherein the nozzle and a flow rate of the pump are configured to provide a plurality of pump pulses and each of the plurality of pump pulses provides a plurality of shedding pulses.

7 . The apparatus of claim 1 , wherein each of a plurality of pump pulses is configured to generate the plurality of pulsatile shear waves.

8 . The apparatus of claim 1 , wherein the nozzle is configured to be arranged to be directed toward the tissue to be treated, wherein jet hydrodynamic parameters are configured to allow mechanical disruption of the tissue.

9 . The apparatus of claim 8 , wherein the jet hydrodynamic parameters comprise one or more of a fluid jet velocity or a shear stress field.

10 . The apparatus of claim 1 , wherein jet hydrodynamic parameters are configured to generate the plurality of pulsatile shear waves.

11 . The apparatus of claim 1 , wherein the plurality of pulsatile shear waves is configured to interact with an affected location of the tissue and promotes hemostasis at the affected location.

12 . The apparatus of claim 1 , wherein the circuitry is configured to provide a jet, wherein the jet comprises a substantially abrasive jet in order to remove vessels and non-vascular tissue at similar rates.

13 . The apparatus of claim 1 , wherein the plurality of pulsatile shear waves is configured to remove the tissue along a removal profile and decrease bleeding at a distance from the removal profile.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 25, 2024
From: ALJURI, NIKOLAI; KARPMAN, EDWARD; DANEK, CHRIS
To: PROCEPT BIOROBOTICS CORPORATION
Reel/Frame 067828/0843 →
Continuity (7)
Continuation 17661486 · Apr 29, 2022
Continuation 16555019 · Aug 29, 2019
Division 15388515 · Dec 22, 2016
Continuation PCTUS2015038605 · Jun 30, 2015
Provisional Application 62032958 · Aug 4, 2014
Provisional Application 62019299 · Jun 30, 2014
Related Publication 20240407799A1 · Dec 12, 2024
References Cited (243)
US 3818913A · Wallach · 1974 [cited by applicant]
US 3821510A · Muncheryan · 1974 [cited by applicant]
US 3847988A · Gold · 1974 [cited by applicant]
US 3875229A · Gold · 1975 [cited by applicant]
US 3930505A · Wallach · 1976 [cited by applicant]
US 4097578A · Perronnet · 1978 [cited by applicant]
US 4220735A · Dieck · 1980 [cited by applicant]
US 4239776A · Bayles · 1980 [cited by applicant]
US 4377584A · Rasmusson · 1983 [cited by applicant]
US 4386080A · Crossley · 1983 [cited by applicant]
US 4389071A · Johnson, Jr. · 1983 [cited by applicant]
US 4461283A · Doi · 1984 [cited by applicant]
US 4474251A · Johnson, Jr. · 1984 [cited by applicant]
US 4560373A · Sugino · 1985 [cited by applicant]
US 4636505A · Tucker · 1987 [cited by applicant]
US 4672963A · Barken · 1987 [cited by applicant]
US 4760071A · Rasmusson · 1988 [cited by applicant]
US 4776349A · Nashef · 1988 [cited by applicant]
US 4913698A · Ito · 1990 [cited by applicant]
US 5037431A · Summers · 1991 [cited by applicant]
US 5116615A · Gokcen · 1992 [cited by applicant]
US 5135482A · Neracher · 1992 [cited by applicant]
US 5207672A · Roth · 1993 [cited by applicant]
US 5257991A · Fletcher · 1993 [cited by applicant]
US 5267341A · Shearin · 1993 [cited by applicant]
US 5269785A · Bonutti · 1993 [cited by applicant]
US 5322503A · Desai · 1994 [cited by applicant]
US 5322504A · Doherty · 1994 [cited by applicant]
US 5454782A · Perkins · 1995 [cited by applicant]
US 5496267A · Drasler · 1996 [cited by applicant]
US 5505729A · Rau · 1996 [cited by applicant]
US 5514669A · Selman · 1996 [cited by applicant]
US 5527330A · Tovey · 1996 [cited by applicant]
US 5558634A · Mitchell · 1996 [cited by applicant]
US 5562703A · Desai · 1996 [cited by applicant]
US 5582190A · Slavin · 1996 [cited by applicant]
US 5620414A · Campbell, Jr. · 1997 [cited by applicant]
US 5630794A · Lax · 1997 [cited by applicant]
US 5649923A · Gregory · 1997 [cited by applicant]
US 5672153A · Lax · 1997 [cited by applicant]
US 5672171A · Andrus · 1997 [cited by applicant]
US 5753641A · Gormley · 1998 [cited by applicant]
US 5770603A · Gibson · 1998 [cited by applicant]
US 5772657A · Hmelar · 1998 [cited by applicant]
US 5773791A · Kuykendal · 1998 [cited by applicant]
US 5782848A · Lennox · 1998 [cited by applicant]
US 5785521A · Rizoiu · 1998 [cited by applicant]
US 5817649A · Labrie · 1998 [cited by applicant]
US 5833701A · Gordon · 1998 [cited by applicant]
US 5836941A · Yoshihara · 1998 [cited by applicant]
US 5861002A · Desai · 1999 [cited by applicant]
US 5871462A · Yoder · 1999 [cited by examiner]
US 5872150A · Elbrecht · 1999 [cited by applicant]
US 5902499A · Richerzhagen · 1999 [cited by applicant]
US 5964775A · Gordon · 1999 [cited by applicant]
US 5994362A · Gormley · 1999 [cited by applicant]
US 6022860A · Engel · 2000 [cited by applicant]
US 6066130A · Gregory · 2000 [cited by applicant]
US 6071284A · Fox · 2000 [cited by applicant]
US 6117128A · Gregory · 2000 [cited by applicant]
US 6142991A · Schatzberger · 2000 [cited by applicant]
US 6179831B1 · Bliweis · 2001 [cited by applicant]
US 6200573B1 · Locke · 2001 [cited by applicant]
US 6217543B1 · Anis · 2001 [cited by applicant]
US 6217860B1 · Woo · 2001 [cited by applicant]
US 6228046B1 · Brisken · 2001 [cited by applicant]
US 6231591B1 · Desai · 2001 [cited by applicant]
US 6254597B1 · Rizoiu · 2001 [cited by applicant]
US 6296639B1 · Truckai · 2001 [cited by applicant]
US 6375635B1 · Moutafis · 2002 [cited by applicant]
US 6378525B1 · Beyar · 2002 [cited by applicant]
US 6413256B1 · Truckai · 2002 [cited by applicant]
US 6425877B1 · Edwards · 2002 [cited by applicant]
US 6440105B1 · Menne · 2002 [cited by applicant]
US 6451017B1 · Moutafis · 2002 [cited by applicant]
US 6565555B1 · Ryan · 2003 [cited by applicant]
US 6572578B1 · Blanchard · 2003 [cited by applicant]
US 6607524B1 · LaBudde · 2003 [cited by applicant]
US 6720745B2 · Lys · 2004 [cited by applicant]
US 6814731B2 · Swanson · 2004 [cited by applicant]
US 6821275B2 · Truckai · 2004 [cited by applicant]
US 6890332B2 · Truckai · 2005 [cited by applicant]
US 6913605B2 · Fletcher · 2005 [cited by applicant]
US 6953461B2 · Mcclurken · 2005 [cited by applicant]
US 6960182B2 · Moutafis · 2005 [cited by applicant]
US 6986764B2 · Davenport · 2006 [cited by applicant]
US 7008421B2 · Daniel · 2006 [cited by applicant]
US 7015253B2 · Escandon · 2006 [cited by applicant]
US 7115100B2 · McRury · 2006 [cited by applicant]
US 7122017B2 · Moutafis · 2006 [cited by applicant]
US 7163875B2 · Richerzhagen · 2007 [cited by applicant]
US 7326054B2 · Todd · 2008 [cited by applicant]
US 7882841B2 · Aljuri · 2011 [cited by applicant]
US 8092507B2 · Tomasello · 2012 [cited by applicant]
US 8795194B2 · Howard · 2014 [cited by applicant]
US 8814921B2 · Aljuri · 2014 [cited by applicant]
US 9232959B2 · Aljuri · 2016 [cited by applicant]
US 9232960B2 · Aljuri · 2016 [cited by applicant]
US 9237902B2 · Aljuri · 2016 [cited by applicant]
US 9364250B2 · Aljuri · 2016 [cited by applicant]
US 9364251B2 · Aljuri · 2016 [cited by applicant]
US 9510853B2 · Aljuri · 2016 [cited by applicant]
US 9668764B2 · Aljuri · 2017 [cited by applicant]
US 9848904B2 · Aljuri · 2017 [cited by applicant]
US 9867635B2 · Alvarez · 2018 [cited by applicant]
US 9931445B2 · Pustilnik · 2018 [cited by applicant]
US 10448966B2 · Aljuri · 2019 [cited by applicant]
US 11213313B2 · Aljuri · 2022 [cited by applicant]
US 11350963B2 · Aljuri · 2022 [cited by examiner]
US 12053202B2 · Aljuri · 2024 [cited by applicant]
US 20010002562A1 · Moutafis · 2001 [cited by applicant]
US 20010048942A1 · Weisman · 2001 [cited by applicant]
US 20020010502A1 · Trachtenberg · 2002 [cited by applicant]
US 20020022869A1 · Hareyama · 2002 [cited by applicant]
US 20020040220A1 · Zvuloni · 2002 [cited by applicant]
US 20020045911A1 · Fletcher · 2002 [cited by applicant]
US 20020111579A1 · Moutafis · 2002 [cited by applicant]
US 20020111617A1 · Cosman · 2002 [cited by applicant]
US 20020128637A1 · von der Heide · 2002 [cited by applicant]
US 20030036768A1 · Hutchins · 2003 [cited by applicant]
US 20030060819A1 · McGovern · 2003 [cited by applicant]
US 20030065321A1 · Carmel · 2003 [cited by applicant]
US 20030073902A1 · Hauschild · 2003 [cited by applicant]
US 20030135205A1 · Davenport · 2003 [cited by applicant]
US 20030139041A1 · Leclair · 2003 [cited by applicant]
US 20030216722A1 · Swanson · 2003 [cited by applicant]
US 20040097829A1 · McRury · 2004 [cited by applicant]
US 20040133254A1 · Sterzer · 2004 [cited by applicant]
US 20040143269A1 · Pude · 2004 [cited by applicant]
US 20050004516A1 · Vanney · 2005 [cited by applicant]
US 20050256517A1 · Boutoussov · 2005 [cited by applicant]
US 20060030787A1 · Quay · 2006 [cited by applicant]
US 20060089626A1 · Vlegele · 2006 [cited by applicant]
US 20060118495A1 · Kondratalv · 2006 [cited by applicant]
US 20060149193A1 · Hall · 2006 [cited by applicant]
US 20060229550A1 · Staid · 2006 [cited by applicant]
US 20070230757A1 · Trachtenberg · 2007 [cited by applicant]
US 20080178654A1 · Hochmitz · 2008 [cited by applicant]
US 20080253527A1 · Boyden · 2008 [cited by applicant]
US 20090018533A1 · Perkins · 2009 [cited by applicant]
US 20090088775A1 · Swarup · 2009 [cited by applicant]
US 20090227998A1 · Aljuri · 2009 [cited by applicant]
US 20100076269A1 · Makower · 2010 [cited by applicant]
US 20100145254A1 · Shadduck · 2010 [cited by applicant]
US 20100179522A1 · Companion · 2010 [cited by applicant]
US 20100179528A1 · Shadduck · 2010 [cited by applicant]
US 20110005288A1 · Matsui · 2011 [cited by applicant]
US 20110104800A1 · Kensy · 2011 [cited by applicant]
US 20110117517A1 · Bergheim · 2011 [cited by applicant]
US 20110184291A1 · Okamura · 2011 [cited by applicant]
US 20110184391A1 · Aljuri · 2011 [cited by applicant]
US 20110208224A1 · Kojima · 2011 [cited by applicant]
US 20120065656A1 · Karwei · 2012 [cited by applicant]
US 20120157841A1 · Glaenzer · 2012 [cited by applicant]
US 20130085442A1 · Shtul · 2013 [cited by applicant]
US 20130158534A1 · Hoey · 2013 [cited by applicant]
US 20130253484A1 · Aljuri · 2013 [cited by applicant]
US 20130253488A1 · Aljuri · 2013 [cited by applicant]
US 20130261540A1 · Crank · 2013 [cited by applicant]
US 20130267889A1 · Aljuri · 2013 [cited by applicant]
US 20140058361A1 · Gordon · 2014 [cited by applicant]
US 20140193833A1 · Srivastava · 2014 [cited by applicant]
US 20140309649A1 · Alvarez · 2014 [cited by applicant]
US 20150025539A1 · Alvarez · 2015 [cited by applicant]
US 20150045777A1 · Aljuri · 2015 [cited by applicant]
US 20150057646A1 · Aljuri · 2015 [cited by applicant]
US 20150088107A1 · Aljuri · 2015 [cited by applicant]
US 20150088110A1 · Aljuri · 2015 [cited by applicant]
US 20150313666A1 · Aljuri · 2015 [cited by examiner]
US 20150335344A1 · Aljuri · 2015 [cited by applicant]
US 20160074059A1 · Aljuri · 2016 [cited by applicant]
US 20160143778A1 · Aljuri · 2016 [cited by applicant]
US 20160228141A1 · Aljuri · 2016 [cited by applicant]
US 20170172548A1 · Aljuri · 2017 [cited by applicant]
US 20170172668A1 · Aljuri · 2017 [cited by applicant]
US 20170231655A1 · Aljuri · 2017 [cited by applicant]
US 20180263647A1 · Aljuri · 2018 [cited by applicant]
CN 101394877 · 2009 [cited by applicant]
CN 101460101A · 2009 [cited by applicant]
CN 102271595A · 2011 [cited by applicant]
CN 102271602 · 2011 [cited by applicant]
CN 102905633 · 2013 [cited by applicant]
CN 103118611 · 2013 [cited by applicant]
CN 103764056 · 2014 [cited by applicant]
EP 1075853A2 · 2001 [cited by applicant]
EP 3188667A1 · 2017 [cited by applicant]
JP 2001046528A · 2001 [cited by applicant]
JP 2002543913 · 2002 [cited by applicant]
JP 2007020837A · 2007 [cited by applicant]
JP 2011167440 · 2011 [cited by applicant]
JP 2012508068A · 2012 [cited by applicant]
JP 2012523253A · 2012 [cited by applicant]
JP 2013518684A · 2013 [cited by applicant]
JP 2015509789 · 2015 [cited by applicant]
WO 03088833A1 · 2003 [cited by applicant]
WO 2004004914 · 2004 [cited by applicant]
WO 2004028592A1 · 2004 [cited by applicant]
WO 2004080529A2 · 2004 [cited by applicant]
WO 2006089426A1 · 2006 [cited by applicant]
WO 2007101015A1 · 2007 [cited by applicant]
WO WO2007114917A2 · 2007 [cited by applicant]
WO 2008083407 · 2008 [cited by applicant]
WO 2009029461A1 · 2009 [cited by applicant]
WO 2009111736 · 2009 [cited by applicant]
WO 2009152613A1 · 2009 [cited by applicant]
WO 2010054220A1 · 2010 [cited by applicant]
WO 2010144419A2 · 2010 [cited by applicant]
WO 2011097505A1 · 2011 [cited by applicant]
WO 2011100753A2 · 2011 [cited by applicant]
WO 2011141775A1 · 2011 [cited by applicant]
WO 2013129657A1 · 2013 [cited by applicant]
WO 2013130895A1 · 2013 [cited by applicant]
WO 2014127242A2 · 2014 [cited by applicant]
WO 2014165703A1 · 2014 [cited by applicant]
WO 2015035249A2 · 2015 [cited by applicant]
WO 2015200538A1 · 2015 [cited by applicant]
WO 2016004071A1 · 2016 [cited by applicant]
WO 2016037132A1 · 2016 [cited by applicant]
WO 2016037137A1 · 2016 [cited by applicant]
Adachi, Yasunori, et al., “Cavitation Noise Characteristics around High-Speed Submerged Water Jets,” Transactions of the Japan Society of Mechanical Engineers, Part B, 60(571):730-735 (1994). [cited by applicant]
Botto, et al., “Electrovaporization of the Prostate with the Gyrus Device,” J. Endourol. (Apr. 2001); 15(3): 313-316. [cited by applicant]
Hillegersberg et al., “Water-jet-cooled Nd:YAG laser coagulation: selective destruction of rat liver metastases,” Lasers Surg Med. 1991; 11(5):445-454. [Abstract Only]. [cited by applicant]
Hutli, Ezddin A.F., et al., “Frequency in Shedding/Discharging Cavitation Clouds Determined by Visualization of a Submerged Cavitating Jet,” Journal of Fluids Engineering, vol. 130, pp. 38-45 (Feb. 2008). [cited by applicant]
International Search Report dated Oct. 1, 2015 for International Patent Application No. PCT/US2015/038605. [cited by applicant]
J. Gaythwaite, The Marine Environment and Structural Design, book, Apr. 1992, pp. 30-33, China Ocean Press, China, with English machine translation. [cited by applicant]
Jian, et al., “The Development of the Water Jet Scalpel With Air Pressure”. Trans. ASME (Jun. 2001), 123(2):246-248. [cited by applicant]
Jun Li and Fuhai Li, Detechtion Technolody and Instrument, book, Jun. 2000, pp. 233-235, China Light Industry Press, China, with English machine translation. [cited by applicant]
Nishimura, Satoshi, et al., “Similarity Law on Shedding Frequency of Cavitation Cloud Induced by a Cavitating Jet,” Journal of Fluid Science and Technology, 7(3):405-420 (2012). [cited by applicant]
Prajapati, et al., “Pluripotent Stern Cell within the Prostate could be Responsible for Benign Prostate Hyperplasia in Human”. J Stem Cell Res Ther (2014); 4:1,11 pages. [cited by applicant]
Prajapati, et al., “Prostate Stem Cells in the Development of Benign Prostate Hyperplasia and Prostate Cancer: Emerging Role and Concepts”. Biomed Res Int (2013); 2013:107954, 11 pages. [cited by applicant]
Richerzhagen et al., “Water Jet Guided Laser Cutting: a Powerful Hybrid Technology for Fine Cutting and Grooving,” Proceedings of the 2004 Advanced Laser Applications Conference and Exposition, Ann Arbor, Michigan, Sep.… [cited by applicant]
Ruggeri, et al., Activation-independent platelet adhesion and aggregation under elevated shear stress. Blood. Sep. 15, 2006; 108(6):1903-1910. [cited by applicant]
Sander et al., “The water jet-guided Nd:YAG laser in the treatment of gastroduodenal ulcer with a visible vessel. A randomized controlled and prospective study,” Endoscopy. Sep. 1989; 21(5):217-220. [Abstract Only]. [cited by applicant]
Sander et al., “Water jet guided Nd:YAG laser coagulation-its application in the field of gastroenterology,” Endosc Surg Allied Technol. Aug. 1993; 1(4):233-238. [Abstract Only]. [cited by applicant]
Soyama, Hitoshi, et al., “Enhancement of Impact Force around a Cavitating Jet by Changing with Nozzle Outlet Geometry,” Japan Society of Mechanical Engineers, pp. 77-85 (2009). [cited by applicant]
Soyama, Hitoshi, et al., “High-Speed Observations of the Cavitation Cloud around a High-Speed Submerged Water Jet,” JSME International Journal Series B, vol. 38, No. 2, 8 pages (May 1995). [cited by applicant]
Stalder et al., “Repetitive Plasma Discharges in Saline Solutions,” Appl. Phys. Lett. (Dec. 2001), 79(27):4503-4505. [cited by applicant]
Tang, Chuanlin, et al., “Effects of Upstream Oscillating Flow on the Self-Excited Oscillation Pulsed Jet,” 994-2023 China Academic Journal Electronic Publishing House; http://www.cnki.net, pp. 24-27 (2001). English abst… [cited by applicant]
Woloszko, et al., “Plasma Characteristics of Repetitively-Pulsed Electrical Discharges in Saline Solutions Used for Surgical Procedures,” IEEE Trans. Plasma Sci. (2002); 30(3): 1376-1383. [cited by applicant]
Xunyi Wu, Automatic Detection Technology—Previous Volume, book, Jan. 1981, pp. 115-118, China Machine Press, China, with English machine translation. [cited by applicant]
Yamauchi, Yoshiaki, et al., “Formation Process of Vortex Ring Cavitation in High-Speed Submerged Water Jets,” Transactions of the Japan Society of Mechanical Engineers, B, No. 95-0502, pp. 72-78 (1996), with English mac… [cited by applicant]
International Preliminary Report on Patentability received for PCT application No. PCT/US15/038605, mailed on Jan. 12, 2017, 11 pages. [cited by applicant]
Wright et al., “Cavitation of a submerged jet.” Exp Fluids (2013); 54:1541, 21 pages. [cited by applicant]