DOUBLE STRANDED RNA TARGETING ANGIOPOIETIN-LIKE 3 (ANGPTL-3) AND METHODS OF USE THEREOF
The disclosure relates to isolated oligonucleotides comprising duplex regions targeting angiopoietin-like 3 (ANGPTL-3), and delivery systems, kits and compositions comprising same, and methods of using same for inhibiting or downregulating ANGPTL-3.
1 . An isolated oligonucleotide comprising a sense strand and an anti-sense strand, wherein:
the sense strand comprises a nucleotide sequence that is substantially identical to a region comprising 19-25 nucleotides between any one of the nucleotide positions selected from:
a) 52 to 93;
b) 133 to 184;
c) 246 to 304;
d) 337 to 414;
e) 433 to 503;
f) 522 to 571;
g) 617 to 700;
h) 717 to 737;
i) 836 to 905;
j) 944 to 964;
k) 1013 to 1093;
l) 1353 to 1386; and
m) 1407 to 1427,
from the 5′ end of an Angiopoietin-like protein 3 (ANGPTL-3) mRNA sequence according to SEQ ID NO: 1,
and the anti-sense strand is substantially complementary to the sense strand such that the sense strand and the anti-sense strand together form a double stranded region.
2 .- 51 . (canceled)