IP Library › Patent Application 18771297
Patent Application
App. No. 18/771,297

INDOLE AHR INHIBITORS AND USES THEREOF

Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US None
App. No.
18/771,297
Abstract

The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.

Claims (89)

1 - 23 . (canceled)

24 . A method of preparing compound I-40:

or a salt thereof, the method comprising a step of reacting compound

or a salt thereof, with compound

or a salt thereof.

25 . The method of claim 24 , further comprising a step of converting compound

or a salt thereof, to compound

or a salt thereof.

26 . The method of claim 25 , further comprising a step of converting compound

or a salt thereof, to compound

or a salt thereof.

27 . The method of claim 26 , further comprising a step of reacting compound

or a salt thereof, with compound

or a salt thereof, to form compound

or a salt thereof.

28 . The method of claim 27 , further comprising a step of converting compound

or a salt thereof, to compound

or a salt thereof.

29 . The method of claim 28 , further comprising a step of converting compound

or a salt thereof, to compound N

or a salt thereof.

30 . The method of claim 29 , further comprising a step of converting compound

or a salt thereof, to compound

or a salt thereof.

31 . The method of claim 24 , wherein compound

or a salt thereof, reacts with compound

or a salt thereof, in a solvent comprising i-PrOH.

32 . The method of claim 24 , wherein compound

or a salt thereof, reacts with compound

or a salt thereof, in presence of compound DIEA.

33 . The method of claim 25 , wherein compound

or a salt thereof, is converted to compound

or a salt thereof, by reacting with compound POCl 3 .

34 . The method of claim 26 , wherein compound

or a salt thereof, is converted to compound

or a salt thereof, by reacting with compound triphosgene.

35 . The method of claim 26 , wherein compound

or a salt thereof, is converted to compound

or a salt thereof, in a solvent comprising 1,4-dioxane and THF.

36 . The method of claim 27 , wherein compound

or a salt thereof, reacts with compound

or a salt thereof, in a solvent comprising xylene.

37 . The method of claim 27 , wherein compound

or a salt thereof, reacts with compound

or a salt thereof, in presence of compound AlMe 3 .

38 . The method of claim 28 , wherein compound

or a salt thereof, is converted to compound

or a salt thereof, in a solvent comprising DCM and TEA.

39 . The method of claim 28 , wherein compound

or a salt thereof, is converted to compound

or a salt thereof, by reacting with compound TFAA.

40 . The method of claim 29 , wherein compound

or a salt thereof, is converted to compound

or a salt thereof, by reacting with compound NH 3 ·H 2 O.

41 . The method of claim 29 , wherein compound

or a salt thereof, is converted to compound

or a salt thereof, by in a solvent comprising THF.

42 . The method of claim 30 , wherein compound

or a salt thereof, is converted to compound

or a salt thereof, by reacting with compound SOCl 2 .

43 . The method of claim 30 , wherein compound

or a salt thereof, is converted to compound

or a salt thereof, in a solvent comprising DMF.

44 . A method of preparing compound I-40:

or a salt thereof, the method comprising steps of:

converting compound

or a salt thereof, to compound

or a salt thereof, by reacting with compound SOCl 2 in a solvent comprising DMF;

converting compound

or a salt thereof, to compound

or a salt thereof, by reacting with compound NH 3 ·H 2 O in a solvent comprising THF;

converting compound

or a salt thereof, to compound

or a salt thereof, by reacting with compound TFAA in a solvent comprising DCM and TEA;

reacting compound

or a salt thereof, with compound

or a salt thereof, in presence of compound AlMe 3 in a solvent comprising xylene, to form compound

or a salt thereof,

converting compound

or a salt thereof, to compound

or a salt thereof, by reacting with compound triphosgene in a solvent comprising 1,4-dioxane and THF;

converting compound

or a salt thereof, to compound

or a salt thereof, by reacting with compound POCl 3 ; and

reacting compound

or a salt thereof, with compound

or a salt thereof, in presence of compound DIEA in a solvent comprising i-PrOH.

45 . A compound selected from the group consisting of:

or a salt thereof.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 22, 2025
From: IKENA ONCOLOGY, INC.
To: PAHR THERAPEUTICS, INC.
Reel/Frame 070907/0364 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 10, 2025
From: CASTRO, ALFREDO C.; EVANS, CATHERINE A.
To: IKENA ONCOLOGY, INC.
Reel/Frame 070161/0707 →