IP Library › Granted Patent US 12,274,743
Granted Patent B2
US 12,274,743 · App. 18/801,143 · Granted Apr 15, 2025

Nucleic acid vaccines

Inventors: Giuseppe Ciaramella (Sudbury, MA); Axel Bouchon (Kleinmacknow, DE); Eric Yi-Chun Huang (Boston, MA)
Assignee: ModernaTX, Inc.
A61K39/145A61K9/0019A61K9/1271A61K9/5123A61K9/5146A61K31/7105A61K39/12A61K39/155A61K39/39A61K48/00C12N7/00A61K2039/53A61K2039/545A61K2039/55555C12N2760/16122C12N2760/16134C12N2760/16234
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Quick Facts
Patent No.
US 12,274,743
App. No.
18/801,143
Granted
Apr 15, 2025
Kind
B2
Abstract

The invention relates to compositions and methods for the preparation, manufacture, and therapeutic use of ribonucleic acid vaccines comprising polynucleotide molecules encoding one or more antigens.

Claims (1)

1. A vaccine comprising a messenger ribonucleic acid (mRNA) formulated in a lipid nanoparticle, wherein the mRNA comprises an open reading frame encoding an influenza hemagglutinin protein, wherein the open reading frame comprises nucleosides consisting of N1-methylpseudouridine, adenosine, guanosine, and cytidine.

Assignments (2)
SECURITY INTEREST Recorded Nov 19, 2025
From: MODERNATX, INC.
To: ARES CAPITAL CORPORATION, AS AGENT
Reel/Frame 073634/0354 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 21, 2025
From: CIARAMELLA, GIUSEPPE; HUANG, ERIC YI-CHUN; BOUCHON, AXEL
To: MODERNATX, INC.
Reel/Frame 070583/0759 →
Continuity (8)
Continuation 17683171 · Feb 28, 2022
Continuation 16144394 · Sep 27, 2018
Continuation 16036318 · Jul 16, 2018
Continuation 15089050 · Apr 1, 2016
Continuation PCTUS2015027400 · Apr 23, 2015
Provisional Application 62088994 · Dec 8, 2014
Provisional Application 61983250 · Apr 23, 2014
Related Publication 20240390480A1 · Nov 28, 2024
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