FIBROBLAST ACTIVATION PROTEIN TARGETING PRECURSOR AND RADIOTRACER
A precursor compound and radiotracer for targeting fibroblast activation protein comprise a chelator Ch and ligand TV with Ch=(Formula) with R═|—CH3 or |—CH2COOH; and TV=(Formula).
1 . Precursor compound for radiotracer having structure Ch-L1-B-L2-TV, wherein
L1 is a bifunctional linker moiety;
L2 is a bifunctional linker moiety;
B is absent or a bifunctional linker moiety;
L1 is configured to covalently bind to Ch and L2 or to Ch and B, if B is present;
B, if present, is configured to covalently bind to L1 and to L2; and
L2 is configured to covalently bind to L1 and TV or to TV and B, if B is present.
2 . Precursor compound according to claim 1 , characterized in that
3 . Precursor compound according to claim 1 , characterized in that absent,
4 . Precursor compound according to claim 1 , characterized in that
with m=1, 2, 3, 4, 5, 6, 7, 8, 9 or 10.
5 . Precursor compound according to claim 4 , characterized in that m=4.
6 . Precursor compound according to claim 1 , characterized in that
with n=1, 2, 3, 4, 5, 6, 7, 8, 9 or 10.
7 . Precursor compound according to claim 6 , characterized in that n=4.
8 . Precursor compound according to claim 1 , characterized in that
9 . Precursor compound according to claim 1 , characterized in that
10 . Precursor compound according to claim 1 , characterized in that
11 . Precursor compound according to claim 1 , characterized in that
12 . Precursor compound according to claim 1 , characterized in that it has the structure
13 . Precursor compound according to claim 1 , characterized in that it has the structure
14 . Precursor compound according to claim 1 , characterized in that it has the structure
15 . Precursor compound according to claim 1 , characterized in that it has the structure
16 . Precursor compound according to claim 1 , characterized in that it has the structure
17 . Radiotracer comprised of the precursor compound according to claim 1 and therewith complexed radioisotope 68 Ga.