IP Library Granted Patent US 12,561,806
Granted Patent B2
US 12,561,806 · App. 18/883,934 · Granted Feb 24, 2026

Compute system with explainable ai for skin lesions analysis mechanism and method of operation thereof

Inventors: Marianne Alix Delphine Defresne (Toulouse, FR); Élise Coutier (Saint Sébastien sur Loire, FR); Paul Fricker (Toulouse, FR); Folkert Blok (Toulouse, FR); Thi Thu Hang Nguyen (Toulouse, FR)
Assignee: BelleTorus Corporation
G06T7/0012G06T7/10G16H50/30G06T2207/20084G06T2207/30088G06T2207/30096
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Quick Facts
Patent No.
US 12,561,806
App. No.
18/883,934
Granted
Feb 24, 2026
Kind
B2
Abstract

A method of operation of a compute system includes: segmenting a skin lesion in a patient image; constructing a normalized image by cropping the patient image and adding padding to position the skin lesion at a center of the normalized image, identifying a skin lesion classification, a skin lesion sub-class, and a risk level assessment by analyzing a symmetry axis, a border, color variation, and dermoscopic structures, and generating a skin lesion display including the normalized image, the skin lesion classification, the skin lesion sub-class, and the risk level assessment for displaying on a device.

Claims (33)

1 . A method of operation of a compute system comprising:

segmenting a skin lesion in a patient image, which is an uploaded image accepted based on a photo guideline;

constructing a normalized image by cropping the patient image and adding padding to position the skin lesion at a center of the normalized image;

identifying a skin lesion classification, a skin lesion sub-class, and a risk level assessment by analyzing a symmetry axis, a border, color variation, and dermoscopic structures, wherein a potential malignancy is determined by a discrepancy between a convex hull and the border of the skin lesion; and

generating a skin lesion display including the normalized image, the skin lesion classification, the skin lesion sub-class, and the risk level assessment for displaying on a device.

2 . The method as claimed in claim 1 further comprising predicting a medical element by calculating a total loss (EQ2) to establish a confidence of accuracy of the skin lesion classification.

3 . The method as claimed in claim 1 further comprising predicting a medical element including a pigment network, a streak, pigmentation, a regression structure, dots and globules, a blue whitish veil, a vascular structure, or a combination thereof.

4 . The method as claimed in claim 1 further comprising generating a negative grayscale format by replacing pixel intensities based on background intensity (EQ1) to assess asymmetry, the border, the color variation, and the dermoscopic structure of the skin lesion.

5 . The method as claimed in claim 1 further comprising assessing a difference between the border and the convex hull, wherein the assessing includes a highlight showing asymmetry of the skin lesion.

6 . The method as claimed in claim 1 further comprising identifying as malignant the skin lesion based on a low number of symmetry axes.

7 . The method as claimed in claim 1 further comprising identifying as benign the skin lesion based on a low number of colors.

8 . A compute system comprising:

a control circuit, including a processor, configured to:

segment a skin lesion in a patient image, which is an uploaded image accepted based on a photo guideline;

construct a normalized image by cropping the patient image and adding padding to position the skin lesion at the center of the normalized image;

identify a skin lesion classification, a skin lesion sub-class, and a risk level assessment by analysis of a symmetry axis, a border, color variation, and dermoscopic structures, wherein a potential malignancy is determined by a discrepancy between a convex hull and the border of the skin lesion; and

generate a skin lesion display including the normalized image, the skin lesion classification, the skin lesion sub-class, and the risk level assessment for displaying on a device.

9 . The system as claimed in claim 8 wherein the control circuit is configured to predict a medical element by calculating a total loss (EQ2) to establish a confidence of accuracy of the skin lesion classification.

10 . The system as claimed in claim 8 wherein the control circuit is configured to predict a medical element including a pigment network, a streak, pigmentation, a regression structure, dots and globules, a blue whitish veil, a vascular structure, or a combination thereof.

11 . The system as claimed in claim 8 wherein the control circuit is further configured to generate a negative grayscale format by replacing pixel intensities based on background intensity (EQ1) to assess asymmetry, the border, the color variation, and the dermoscopic structure of the skin lesion.

12 . The system as claimed in claim 8 wherein the control circuit is further configured to assess a difference between the border and the convex hull, wherein the assessment includes a highlight showing asymmetry of the skin lesion.

13 . The system as claimed in claim 8 wherein the control circuit is further configured to identify as malignant the skin lesion based on a low number of symmetry axes.

14 . The system as claimed in claim 8 wherein the control circuit is further configured to identify as benign the skin lesion based on a low number of colors.

15 . A non-transitory computer readable medium including instructions for a compute system which, when executed by a processor, cause the processor to execute the instructions comprising:

segmenting a skin lesion in a patient image, which is an uploaded image accepted based on a photo guideline;

constructing a normalized image by cropping the patient image and adding padding to position the skin lesion at a center of the normalized image;

identifying a skin lesion classification, a skin lesion sub-class, and a risk level assessment by analyzing a symmetry axis, a border, color variation, and dermoscopic structures, wherein a potential malignancy is determined by a discrepancy between a convex hull and the border of the skin lesion; and

generating a skin lesion display including the normalized image, the skin lesion classification, the skin lesion sub-class, and the risk level assessment for displaying on a device.

16 . The non-transitory computer readable medium as claimed in claim 15 further comprising predicting a medical element by calculating a total loss (EQ2) to establish a confidence of accuracy of the skin lesion classification.

17 . The non-transitory computer readable medium as claimed in claim 15 further comprising predicting a medical element including a pigment network, a streak, pigmentation, a regression structure, dots and globules, a blue whitish veil, a vascular structure, or a combination thereof.

18 . The non-transitory computer readable medium as claimed in claim 15 further comprising generating a negative grayscale format by replacing pixel intensities based on background intensity (EQ1) to assess asymmetry, the border, the color variation, and the dermoscopic structure of the skin lesion.

19 . The non-transitory computer readable medium as claimed in claim 15 further comprising assessing a difference between the border and the convex hull, wherein the assessing includes a highlight showing asymmetry of the skin lesion.

20 . The non-transitory computer readable medium as claimed in claim 15 further comprising identifying as malignant the skin lesion based on a low number of symmetry axes.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 20, 2024
From: DEFRESNE, MARIANNE ALIX DELPHINE, DR.; COUTIER, ÉLISE, DR.; FRICKER, PAUL, DR.; BLOK, FOLKERT, DR.; NGUYEN, THI THU HANG, DR.
To: BELLETORUS CORPORATION
Reel/Frame 069005/0435 →
Continuity (2)
Provisional Application 63634126 · Apr 15, 2024
Related Publication 20250322511A1 · Oct 16, 2025
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