CRYSTALLINE SALT FORMS OF BOC-D-ARG-DMT-LYS-(BOC)-PHE-NH2
Disclosed are various crystalline salt forms of Boc-D-Arg-DMT-Lys(Boc)-Phe-NH 2 .
1 - 16 . (canceled)
17 . A mixture, comprising a crystalline form of Compound (I)
(Boc-D-Arg-DMT-Lys(Boc)-Phe-NH 2; (I)), or salt thereof; a solvent; and an antisolvent.
18 . The mixture of claim 17 , wherein the solvent is selected from methanol, ethanol, trifluoroethanol, and a combination of any of them.
19 . The mixture of claim 18 , wherein the solvent is methanol.
20 . The mixture of claim 17 , wherein the antisolvent is selected from the group consisting of acetonitrile, ethyl acetate, tetrahydrofuran, acetone, methyl ethyl ketone, toluene, tert-butyl methyl ether, heptane, and a combination of any of them.
21 . The mixture of claim 18 , wherein the antisolvent is selected from the group consisting of acetonitrile, ethyl acetate, tetrahydrofuran, acetone, methyl ethyl ketone, toluene, tert-butyl methyl ether, heptane, and a combination of any of them.
22 . The mixture of claim 19 , wherein the antisolvent is selected from the group consisting of acetonitrile, ethyl acetate, tetrahydrofuran, acetone, methyl ethyl ketone, toluene, tert-butyl methyl ether, heptane, and a combination of any of them.
23 . The mixture of claim 17 , wherein the ratio of the solvent to the antisolvent is about 3:1 to about 1:3.
24 . The mixture of claim 23 , wherein the ratio of the solvent to the antisolvent is about 3:1.
25 . The mixture of claim 23 , wherein the ratio of the solvent to the antisolvent is about 1:3.
26 . The mixture of claim 17 , wherein the mixture is a slurry, a suspension, or a solution.
27 . The mixture of claim 26 , wherein the mixture is a slurry.
28 . The mixture of claim 26 , wherein the mixture is a suspension.
29 . The mixture of claim 26 , wherein the mixture is a solution.