IP Library › Granted Patent US 12,416,021
Granted Patent B1
US 12,416,021 · App. 18/913,027 · Granted Sep 16, 2025

Composition for regulating production of proteins

Inventor: Bradley G. Thompson (Calgary, CA)
Assignee: Wyvern Pharmaceuticals Inc.
C12N15/86C07K14/51C12N2750/14143
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Quick Facts
Patent No.
US 12,416,021
App. No.
18/913,027
Granted
Sep 16, 2025
Kind
B1
Abstract

Some embodiments of the present disclosure relate to one or more compositions that upregulate the production of one or more sequences of mRNA. The sequences of mRNA may encode for translation of a target biomolecule, thereby causing an increase in the bioavailability of the target biomolecule within a subject that is administered the one or more compositions. In some embodiments of the present disclosure, the target biomolecule is a protein such as BMP11.

Claims (7)

1. A composition that comprises a recombinant plasmid (RP) comprising a sequence of nucleotides with 95-100% identity to the nucleotide sequence of SEQ ID NO. 2, wherein the sequence of nucleotides encodes for a sequence of messenger ribonucleic acid (mRNA) that encodes for a bone morphogenetic protein 11 (BMP11).

2. The composition of claim 1 , wherein the RP is encased in a protein coat, a lipid vesicle, or any combination thereof.

3. The composition of claim 1 , wherein the RP is configured to be delivered to a target cell.

4. The composition of claim 1 , wherein the RP is encased in a viral vector.

5. The composition of claim 4 , wherein the viral vector is a double-stranded DNA virus, a single-stranded DNA virus, a single-stranded RNA virus, or a double-stranded RNA virus.

6. The composition of claim 4 , wherein the viral vector is an adeno-associated virus.

7. A composition that comprises a RP comprising a sequence of nucleotides with 95-100% identity to the nucleotide sequence of SEQ ID NO. 3, wherein the sequence of nucleotides encodes for a sequence of mRNA that encodes for a BMP11.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 29, 2025
From: THOMPSON, BRADLEY G.
To: WYVERN PHARMACEUTICALS INC.
Reel/Frame 072412/0406 →
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