Needle Assisted Injection Device Having Reduced Trigger Force

1 - 20 . (canceled)

21 . A method for delivering a medicament to a subject in need thereof, the method comprising injecting the medicament in the subject using an injector comprising:

a trigger mechanism including:

a trigger member disposed about an axis, the trigger member having a trigger member protrusion and an opening defined by a trigger member opening wall, and

a ram assembly having a ram configured to pressurize a medicament container for expelling a medicament therefrom, the ram assembly further having a trigger engagement member configured to be positioned in the opening and engage the trigger member opening wall when the trigger member is in a pre-firing condition;

an energy source associated with the ram for powering the ram to expel the medicament; and

a guard including a guard aperture receiving the trigger member protrusion and operable for causing an axial translation of the trigger member in a proximal direction from the pre-firing condition to a firing condition in which the trigger engagement member is disengaged from the trigger member opening wall to avow the energy source to fire the ram.

22 . The method of claim 21 , wherein the energy source is configured to pressurize the medicament to between about 80 psi and about 1000 psi to jet inject the medicament.

23 . The method of claim 21 , wherein a needle connected to the medicament container is exposed by the guard upon the proximal movement of the guard, wherein the guard is retractable.

24 . The method of claim 23 , wherein the needle is in fluid communication with the medicament container for injecting the medicament expelled therefrom during firing.

25 . The method of claim 23 , wherein the energy source and the needle are configured for jet injecting the medicament through the needle.

26 . The method of claim 23 , wherein the medicament is injected through the needle at a needle insertion depth of about 8 mm or less.

27 . The method of claim 23 , wherein the medicament is injected through the needle at a needle insertion depth of about 6 mm or less.

28 . The method of claim 23 , wherein the medicament is injected through the needle at a needle insertion depth of about 4 mm or less.

29 . The method of claim 21 , wherein up to about 3 mL of the medicament is delivered.

30 . The method of claim 21 , wherein about 0.5 mL, about 1 mL, about 1.5 mL, about 2 mL, about 2.5 mL or about 3 mL of the medicament is delivered.

31 . The method of claim 21 , wherein about 0.5 mL of the medicament is delivered.

32 . The method of claim 21 , wherein the medicament is delivered at a rate of between about 0.2 mL/sec and about 0.75 mL/sec.

33 . The method of claim 21 , wherein the medicament is delivered at a rate of about 0.2 mL/sec, about 0.3 mL/sec, about 0.35 mL/sec, about 0.4 mL/sec, about 0.45 mL/sec, about 0.5 mL/sec, about 0.55 mL/sec, about 0.6 mL/sec, about 0.65 mL/sec, about 0.7 mL/sec, or about 0.75 mL/sec.

34 . The method of claim 21 , wherein the medicament comprises a thrombolytic.

35 . The method of claim 34 , wherein the thrombolytic is a P2Y12 inhibitor.

36 . The method of claim 21 , wherein the medicament comprises an aqueous solution.

37 . A method for delivering a medicament to a subject in need thereof, the method comprising injecting the medicament in the subject using an injector comprising:

a trigger mechanism including:

a trigger member disposed about an axis, the trigger member having a trigger member protrusion and an opening defined by a trigger member opening wall, and

a ram assembly having a ram configured to pressurize a medicament container for expelling a medicament therefrom, the ram assembly further having a trigger engagement member configured to be positioned in the opening and engage the trigger member opening wall when the trigger member is in a pre-firing condition;

an energy source associated with the ram for powering the ram to expel the medicament; and

a guard including a guard aperture receiving the trigger member protrusion and operable for causing an axial translation of the trigger member in a proximal direction from the pre-firing condition to a firing condition in which the trigger engagement member is disengaged from the trigger member opening wall to avow the energy source to fire the ram;

wherein the energy source is configured to pressurize the medicament to between about 80 psi and about 1000 psi to jet inject the medicament;

wherein a needle connected to the medicament container is exposed by the guard upon the proximal movement of the guard, wherein the guard is retractable;

wherein the medicament is injected through the needle at a needle insertion depth of about 8 mm or less;

wherein up to about 3 mL of the medicament is delivered;

wherein the medicament is delivered at a rate of between about 0.2 mL/sec and about 0.75 mL/sec;

wherein the medicament comprises a thrombolytic; and

wherein the medicament comprises an aqueous solution.)

38 . A method for delivering a medicament to a subject in need thereof, the method comprising injecting the medicament in the subject using an injector comprising:

a trigger mechanism including:

a trigger member disposed about an axis, the trigger member having a trigger member protrusion and an opening defined by a trigger member opening wall, and

a ram assembly having a ram configured to pressurize a medicament container for expelling a medicament therefrom, the ram assembly further having a trigger engagement member configured to be positioned in the opening and engage the trigger member opening wall when the trigger member is in a pre-firing condition;

an energy source associated with the ram for powering the ram to expel the medicament; and

a guard including a guard aperture receiving the trigger member protrusion and operable for causing an axial translation of the trigger member in a proximal direction from the pre-firing condition to a firing condition in which the trigger engagement member is disengaged from the trigger member opening wall to avow the energy source to fire the ram;

wherein the energy source is configured to pressurize the medicament to between about 80 psi and about 1000 psi to jet inject the medicament;

wherein a needle connected to the medicament container is exposed by the guard upon the proximal movement of the guard, wherein the guard is retractable;

wherein the medicament is injected through the needle at a needle insertion depth of about 8 mm or less;

wherein up to about 3 mL of the medicament is delivered;

wherein the medicament comprises a thrombolytic; and

wherein the medicament comprises an aqueous solution.