IP Library Granted Patent US 12,465,256
Granted Patent B1
US 12,465,256 · App. 18/932,963 · Granted Nov 11, 2025

Systems and methods for endoscopic manometry

Inventors: John Erik Pandolfino (Wilmette, IL); Dustin Allan Carlson (Chicago, IL)
Assignee: Northwestern Memorial Healthcare
A61B5/227A61B5/6853A61B2562/0247
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Quick Facts
Patent No.
US 12,465,256
App. No.
18/932,963
Granted
Nov 11, 2025
Kind
B1
Abstract

Systems and methods include techniques associated with endoscopic manometry. An inflatable structure may be inserted within a tissue structure and inflated or deflated to induce a physiological response for a patient. In operation, the physiological response may be induced while a patient is sedated, which may decrease physical and/or psychological pain to the patient.

Claims (36)

1 . A method, comprising:

positioning an inflatable structure at a designated position associated with a tissue structure of a patient;

causing a change in at least one of a volume, a cross-sectional area, or a diameter of the inflatable structure;

determining the change successfully induced a target physiological response;

logging one or more measurements associated with a condition of the tissue structure;

reversing the change in at least one of the volume, the cross-sectional area, or the diameter of the inflatable structure;

causing a second change in at least one of the volume, the cross-sectional area, or the diameter of the inflatable structure;

determining the second change was unsuccessful in inducing the target physiological response;

waiting for a threshold period of time;

after the threshold period of time, determining the second change successfully induced the target physiological response;

logging one or more second measurements associated with the condition of the tissue structure; and

removing the inflatable structure from the tissue structure.

2 . The method of claim 1 , wherein the tissue structure is an esophagus and the one or more measurements are pressure measurements from a manometer.

3 . The method of claim 1 , wherein the inflatable structure is a balloon.

4 . The method of claim 1 , wherein causing the change in at least one of a volume, a cross-sectional area, or a diameter of the inflatable structure further comprises:

directing air into the inflatable structure or removing air from the inflatable structure.

5 . The method of claim 1 , wherein the target physiological response is at least one of relaxation of a lower esophageal sphincter or peristalsis.

6 . The method of claim 1 , wherein at least the positioning of the inflatable structure and the causing the change in at least one of the volume, the cross-sectional area, or the diameter of the inflatable structure is performed while the patient is sedated.

7 . A method, comprising:

positioning an inflatable structure at a designated position associated with a tissue structure of a patient;

causing a change in at least one of a volume, a cross-sectional area, or a diameter of the inflatable structure;

determining the change successfully induced a target physiological response;

logging one or more measurements associated with a condition of the tissue structure;

causing a second change in at least one of the volume, the cross-sectional area, or the diameter of the inflatable structure;

determining the second change was unsuccessful in inducing the target physiological response;

waiting for a threshold period of time;

after the threshold period of time, determining the second change successfully induced the target physiological response;

logging one or more second measurements associated with the condition of the tissue structure

reversing at least one of the change or the second change in at least one of the volume, the cross-sectional area, or the diameter of the inflatable structure; and

removing the inflatable structure from the tissue structure.

8 . The method of claim 7 , wherein the tissue structure is an esophagus and the one or more measurements are pressure measurements from a manometer.

9 . The method of claim 7 , wherein the inflatable structure is a balloon.

10 . The method of claim 7 , wherein causing the change in at least one of a volume, a cross-sectional area, or a diameter of the inflatable structure further comprises:

directing air into the inflatable structure or removing air from the inflatable structure.

11 . The method of claim 7 , wherein the target physiological response is at least one of relaxation of a lower esophageal sphincter or peristalsis.

12 . The method of claim 7 , wherein at least the positioning of the inflatable structure and the causing the change in at least one of the volume, the cross-sectional area, or the diameter of the inflatable structure is performed while the patient is sedated.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 21, 2024
From: PANDOLFINO, JOHN ERIK; CARLSON, DUSTIN ALLAN
To: NORTHWESTERN MEMORIAL HEALTHCARE
Reel/Frame 069355/0331 →
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