IP Library Granted Patent US 10,898,091
Granted Patent B2
US 10,898,091 · App. 15/546,986 · Granted Jan 26, 2021

Systems, methods, and apparatus for esophageal panometry

Inventors: John Erik Pandolfino (Chicago, IL); Zhiyue Lin (Chicago, IL); Peter J. Kahrilas (Chicago, IL); John O'Dea (Galway, IE); Adrian McHugh (Galway, IE)
Assignee: NORTHWESTERN UNIVERSITY
A61B5/037A61B1/273A61B5/0538A61B5/4233A61B5/6853A61B5/687
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Quick Facts
Patent No.
US 10,898,091
App. No.
15/546,986
Granted
Jan 26, 2021
Kind
B2
Abstract

Systems, methods, and apparatus for esophageal panometry are provided. An example method includes capturing measurement data including an area and a pressure of an esophageal body via a measurement device positioned with respect to the esophageal body; generating representations of the exported measurement data; analyzing the measurement data to determine esophageal reactivity based on the area and pressure; assessing esophageal function based on the determined esophageal reactivity; and outputting an indication of esophageal function.

Claims (30)

1. A method comprising:

inflating a measurement device positioned with respect to an esophageal body to trigger esophageal reactivity, the measurement device configured to measure a change in the impedance derived cross-sectional area and pressure of the esophageal body over a period of time to examine the shape of the esophagus;

capturing measurement data including the impedance derived cross-sectional area and the pressure of the esophageal body via the measurement device;

creating, by a computer processor, a time-based topography plot from the measurement data;

analyzing, by the computer processor, the topography plot to determine esophageal reactivity based on Repetitive Antegrade Contractions given by the impedance derived cross-sectional area and pressure;

assessing, by the computer processor, esophageal function based on the determined esophageal reactivity; and

based on the assessing, outputting an indication of esophageal function via a user interface.

2. The method of claim 1 , wherein the measurement device includes an inflatable balloon positioned with respect to the esophageal body to trigger a physical reaction by conforming to available space in the esophageal body.

3. The method of claim 2 , wherein a distension of the balloon and a physiological response to the distension are indicative of a health condition.

4. The method of claim 3 , wherein the health condition includes at least one of stricture, eosinophilic esophagitis, or achalasia.

5. The method of claim 1 , wherein the measurement device is configured to measure a plurality of impedance derived cross-sectional areas and a plurality of pressures of the esophageal body.

6. The method of claim 1 , wherein the measurement device includes a functional lumen imaging probe including an inflatable portion and a pressure sensor.

7. A system comprising:

a measurement device positioned with respect to an esophageal body configured to inflate and trigger esophageal reactivity, the measurement device configured to measure a change in the impedance derived cross-sectional area and pressure of the esophageal body over a period of time to examine the shape of the esophagus; and

a processor configured to:

create a time-based topography plot from the exported measurement data including the impedance derived cross-sectional area and the pressure of an esophageal body captured via the measurement device;

analyze the topography plot to determine esophageal reactivity based on Repetitive Antegrade Contractions given by the impedance derived cross-sectional area and pressure;

assess esophageal function based on the determined esophageal reactivity; and

based on the assessing, output an indication of esophageal function via a user interface.

8. The system of claim 7 , wherein the measurement device includes an inflatable balloon positioned with respect to the esophageal body to trigger a physical reaction by conforming to available space in the esophageal body.

9. The system of claim 8 , wherein a distension of the balloon and a physiological response to the distension are indicative of a health condition.

10. The system of claim 7 , wherein the measurement device is configured to measure a plurality of impedance based cross-sectional areas and a plurality of pressures of the esophageal body.

11. The system of claim 7 , wherein the measurement device includes a functional lumen imaging probe including an inflatable portion and a pressure sensor.

12. A tangible computer readable medium including instructions which, when executed by a processor, configure the processor to implement a method, the method comprising:

inflating a measurement device positioned with respect to an esophageal body to trigger esophageal reactivity, the measurement device configured to measure a change in the impedance derived cross-sectional area and pressure of the esophageal body over a period of time to examine the shape of the esophagus;

creating, by the processor a time-based topography plot from measurement data including the impedance derived cross-sectional area and the pressure of the esophageal body captured via the measurement device;

analyzing, by the processor, the topography plot to determine esophageal reactivity based on Repetitive Antegrade Contractions given by the impedance derived cross-sectional area and pressure;

assessing, by the processor, esophageal function based on the determined esophageal reactivity; and

based on the assessing, outputting an indication of esophageal function via a user interface.

13. The computer readable medium of claim 12 , wherein the measurement device includes an inflatable balloon positioned with respect to the esophageal body to trigger a physical reaction by conforming to available space in the esophageal body.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 11, 2018
From: O'DEA, JOHN; MCHUGH, ADRIAN
To: CROSPON LTD.
Reel/Frame 044600/0563 →
Continuity (2)
Provisional Application 62110867 · Feb 2, 2015
Related Publication 20180008156A1 · Jan 11, 2018