Systems and methods for removal of biological objects from anatomical structures within a body
Implementations of the present disclosure generally relate to medical aspiration devices and their methods of use. In some cases, the devices are configured to create a vacuum to capture and/or immobilize a solid deposit at a location internal to a subject. Such configurations may be useful, for example, for removing intact kidney stones small enough to pass through the ureter. In some cases, the devices further include an ablation instrument. Such devices may be useful, for example, for ablating larger solid deposits into a plurality of smaller particles at a location internal to the subject (e.g., ablating kidney stones that are too large to pass through the ureter). In some cases, the vacuum created by the devices is used to remove the plurality of smaller particles from the location internal to the subject.
1. A method of removing a biological object from a urinary tract, the method comprising:
creating a vacuum with a catheter positioned in the urinary tract, wherein the catheter includes a proximal end and a distal end, an evacuation lumen positioned at least partially within a catheter body of the catheter, and a supply lumen configured to transport a liquid to the distal end of the catheter, wherein the vacuum is present at a distal face opening in the catheter body to attract the biological object toward the distal face opening, and wherein the vacuum is created, via a Venturi effect, by transporting the liquid through the supply lumen and ejecting the liquid as a liquid jet outside the supply lumen at a position proximal to the distal end;
breaking the biological object with an ablation instrument at least partially positioned within the catheter body, wherein the ablation instrument includes a laser that comprises a distal tip positioned distally of an outlet of the supply lumen; and
regulating a fluid flow in the evacuation lumen as at least a portion of the biological object enters the evacuation lumen,
wherein the vacuum and regulation of the fluid flow facilitate attracting the biological object toward the distal face opening and removing the biological object from the urinary tract through the evacuation lumen and toward the proximal end of the catheter.
2. The method of claim 1 , wherein the ablation instrument is at least partially positioned within the evacuation lumen.
3. The method of claim 1 , wherein creating the vacuum comprises directing a flow of the liquid from the proximal end of the catheter body toward the distal end of the catheter body and redirecting the flow of the liquid proximally.
4. The method of claim 3 , wherein the supply lumen directs the flow of liquid toward the distal end of the catheter body through a first cross-sectional area and redirects the flow of the liquid toward the proximal end of the catheter body at the distal end of the catheter body into a second cross-sectional area greater than the first cross-sectional area.
5. A method of removing a biological object from a urinary tract, the method comprising:
creating a vacuum with a catheter positioned in the urinary tract, wherein the catheter includes a proximal end and a distal end, an evacuation lumen positioned at least partially within a catheter body of the catheter, and a supply lumen configured to transport a liquid to the distal end of the catheter, wherein the vacuum is present at a distal face opening in the catheter body to attract the biological object toward the distal face opening, and wherein the vacuum is created, via a Venturi effect, by transporting the liquid through the supply lumen and ejecting the liquid as a liquid jet outside the supply lumen at a position proximal to the distal end;
breaking the biological object with an ablation instrument at least partially positioned within the catheter body, wherein the ablation instrument comprises a distal tip positioned distally of an outlet of the supply lumen; and
regulating a fluid flow in the evacuation lumen as at least a portion of the biological object enters the evacuation lumen, wherein regulating the fluid flow comprises applying a vacuum source to the evacuation lumen at the proximal end of the catheter.
6. A method of removing a biological object from a urinary tract, the method comprising:
creating a vacuum with a catheter positioned in the urinary tract, wherein the catheter includes a proximal end and a distal end, an evacuation lumen positioned at least partially within a catheter body of the catheter, and a supply lumen configured to transport a liquid to the distal end of the catheter, wherein the vacuum is present at the distal end of the catheter to attract the biological object toward the distal end, and wherein the vacuum is created, via a Venturi effect, by transporting the liquid through the supply lumen and ejecting the liquid outside the supply lumen at a position proximal to the distal end;
breaking the biological object with an ablation instrument at least partially positioned within the catheter body;
aspirating at least a portion of the biological object through the distal end and transporting at least the portion of the biological object along the evacuation lumen toward the proximal end of the catheter; and
maintaining a fluid balance and pressure balance in the urinary tract by resupplying into the urinary tract at least some of the liquid ejected from the supply lumen.
7. The method of claim 6 , wherein resupplying into the urinary tract at least some of the liquid ejected from the supply lumen is performed through a plurality of vents formed in the catheter body.
8. The method of claim 6 , wherein maintaining the fluid balance and pressure balance in the urinary tract comprises operating a vacuum source in fluid communication with the evacuation lumen to regulate a flow rate.
9. The method of claim 8 , wherein the vacuum source is in fluid communication with the proximal end of the catheter.
10. The method of claim 8 , further comprising controlling the vacuum source with a controller configured to maintain a temperature in the urinary tract at or below a temperature threshold indicative of safe operating temperature.
11. The method of claim 10 , wherein the controller is in electrical communication with one or more sensors.
12. The method of claim 10 , wherein controlling the vacuum source with a controller comprises receiving feedback from one or more sensors.
13. The method of claim 12 , wherein the one or more sensors comprise one or more temperature sensors or one or more pressure sensors.
14. A method of removing a biological object from a urinary tract, the method comprising:
creating a vacuum with a catheter positioned in the urinary tract, wherein the catheter includes a proximal end and a distal end, an evacuation lumen positioned at least partially within a catheter body of the catheter, and a supply lumen configured to transport a liquid to the distal end of the catheter, wherein the vacuum is present at the distal end of the catheter to attract the biological object toward the distal end, and wherein the vacuum is created by transporting the liquid through the supply lumen from the proximal end to the distal end, redirecting the liquid toward the proximal end, and ejecting the liquid outside the supply lumen into the evacuation lumen at a position proximal to the distal end;
breaking the biological object with an ablation instrument at least partially positioned within the catheter body;
aspirating at least a portion of the biological object through the distal end and transporting the biological object along the evacuation lumen toward the proximal end of the catheter; and
maintaining a fluid balance and pressure balance in the urinary tract by resupplying into the urinary tract at least some of the liquid ejected from the supply lumen.
15. The method of claim 14 , wherein the liquid is provided to the supply lumen as a liquid jet.
16. The method of claim 15 , wherein the liquid is a first liquid and ejecting the liquid jet into the evacuation lumen induces fluid flow of a second liquid from a volume external to the catheter into the evacuation lumen.
17. The method of claim 14 , wherein maintaining the fluid balance and pressure balance in the urinary tract comprises operating a vacuum source in fluid communication with the evacuation lumen to regulate a flow rate.
18. The method of claim 17 , wherein the vacuum source is in fluid communication with the proximal end of the catheter.
19. The method of claim 17 , further comprising controlling the vacuum source with a controller configured to maintain a temperature in the urinary tract at or below a temperature threshold indicative of safe operating temperature.
20. The method of claim 19 , wherein the controller is in electrical communication with one or more temperature sensors.
21. The method of claim 19 , wherein controlling the vacuum source with a controller comprises receiving feedback from one or more temperature sensors.
22. The method of claim 17 , further comprising controlling the vacuum source with a controller configured to maintain a pressure in the urinary tract at or below a pressure threshold indicative of safe operating pressure.
23. The method of claim 22 , wherein the controller is in electrical communication with one or more pressure sensors.
24. The method of claim 22 , wherein controlling the vacuum source with a controller comprises receiving feedback from one or more pressure sensors.
25. The method of claim 14 , wherein redirecting the liquid toward the proximal end comprises redirecting a distal flow direction in a radially outward supply lumen to a proximal flow direction in a radially inward aspiration lumen.
26. The method of claim 25 , wherein the radially outward supply lumen comprises a first volume with a first cross sectional area less than the radially inward aspiration lumen comprising a second volume with a second cross sectional area.
27. The method of claim 26 , wherein the catheter comprises a third volume at a proximal end of the catheter in fluid communication with an exterior volume, wherein redirecting the distal flow direction to the proximal flow direction ejects a flow of the liquid through the third volume inducing a second fluid in the exterior volume to flow in the proximal flow direction through the radially inward aspiration lumen.