Granted Patent
B2
US 12,349,967 · App. 18/939,459 · Granted Jul 8, 2025
Methods, apparatuses, and systems for the treatment of pulmonary disorders
Inventors:
Jonathan Reuben Waldstreicher (West Orange, NJ); William Sanford Krimsky (Forest Hil, MD); Denise Marie Zarins (Saratoga, CA); Robert J. Beetel, III (Sunnyvale, CA); Paul Brian Friedrichs (Belmont, CA); Kevin James Taylor (San Mateo, CA); Roman Turovskiy (San Francisco, CA); Gary L. Long (Cincinnati, OH)
Assignee:
Galvanize Therapeutics, Inc.
A61B18/1492A61B18/1206A61N1/06A61N1/327A61B2018/0016A61B2018/0022A61B2018/00267A61B2018/00541A61B2018/00577A61B2018/00642A61B2018/00648A61B2018/00678A61B2018/00702A61B2018/00791A61B2018/00839A61B2018/00875A61B2018/1435A61B2018/1467
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Abstract
Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The system may be used to treat a variety of pulmonary diseases or disorders such as or associated with COPD (e.g., chronic bronchitis, emphysema), asthma, interstitial pulmonary fibrosis, cystic fibrosis, bronchiectasis, primary ciliary dyskinesia (PCD), acute bronchitis and/or other pulmonary diseases or disorders.
Claims (31)
1. A system for treating a target tissue of a patient, comprising:
at least one energy delivery body positionable near the target tissue;
a dispersive electrode positionable upon the patient at a location that causes the at least one energy delivery body to function in a monopolar fashion; and
a generator comprising at least one energy delivery algorithm configured to provide pulsed high voltage energy having a voltage of 500 to 5000 volts and packets of pulses that cause disruption of at least intracellular organelles of the target tissue, thereby leading to cell death by non-thermal mechanisms.
2. The system of claim 1 , wherein the pulsed high voltage energy has a frequency of 100-500 kHz.
3. The system of claim 2 , wherein each packet of the packets of pulses has a cycle count of up to 40 cycles.
4. The system of claim 1 , wherein the pulsed high voltage energy has a frequency of 500-800 kHz.
5. The system of claim 4 , wherein each packet of the packets of pulses has a cycle count of up to 60 cycles.
6. The system of claim 1 , wherein the non-thermal mechanism comprises programmed cell death.
7. The system of claim 1 , wherein the cell death causes an inflammatory cascade to ensue.
8. The system of claim 1 , wherein the target tissue resides within a lung of the patient.
9. The system of claim 1 , wherein each of the packets of pulses are separated by a rest period of 0.1 to 5 seconds.
10. The system of claim 1 , wherein each of the packets of pulses are separated by a rest period having a duration that varies so as to synchronize with a heartbeat of the patient.
11. The system of claim 1 , wherein the packets of pulses cause disruption of both cell membranes and the intracellular organelles.
12. The system of claim 11 , wherein the pulsed high voltage energy has only a partial effect on the cell membranes or the intracellular organelles, and wherein a cumulative effect on both the cell membranes or the intracellular organelles ultimately yields the cell death.
13. The system of claim 1 , wherein the packets of pulses comprise up to 100 packets.
14. The system of claim 1 , wherein the packets of pulses comprise 100 packets.
15. A system for treating a target tissue of a patient, comprising:
at least one energy delivery body positionable near the target tissue;
a dispersive electrode positionable upon the patient at a location that causes the at least one energy delivery body to function in a monopolar fashion; and
a generator comprising at least one energy delivery algorithm configured to provide pulsed high voltage energy comprising packets of pulses that cause disruption of both cell membranes and intracellular organelles of the target tissue, thereby leading to cell death by non-thermal mechanisms.
16. The system of claim 15 , wherein the pulsed high voltage energy has a frequency of 100-500 KHz.
17. The system of claim 16 , wherein the pulsed high voltage energy has a frequency of 400 kHz.
18. The system of claim 15 , wherein the pulsed high voltage energy has a voltage of 500 to 5000 volts.
19. The system of claim 15 , wherein each packet of the packets of pulses has a cycle count of up to 40 cycles.
20. The system of claim 15 , wherein each of the packets of pulses are separated by a rest period of 0.1 to 5 seconds.
21. The system of claim 15 , wherein each of the packets of pulses are separated by a rest period having a duration that varies so as to synchronize with a heartbeat of the patient.
22. The system of claim 15 , wherein the pulsed high voltage energy has only a partial effect on the cell membranes or intracellular organelles, and wherein a cumulative effect on both the cell membranes or the intracellular organelles ultimately yields the cell death.
23. The system of claim 15 , wherein the packets of pulses comprise up to 100 packets.
24. The system of claim 15 , wherein the packets of pulses comprise 100 packets.
25. The system of claim 15 , wherein the non-thermal mechanism comprises programmed cell death.
Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 15, 2025
From: WALDSTREICHER, JONATHAN REUBEN; KRIMSKY, WILLIAM SANFORD; ZARINS, DENISE MARIE; BEETEL, ROBERT J., III; FRIEDRICHS, PAUL BRIAN; TAYLOR, KEVIN JAMES; TUROVSKIY, ROMAN; LONG, GARY L.
To: GALA THERAPEUTICS, INC.
Reel/Frame 071122/0465 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 15, 2025
From: GALA THERAPEUTICS, INC.
To: GALARY, INC.
Reel/Frame 071123/0033 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 15, 2025
From: GALARY, INC.
To: GALVANIZE THERAPEUTICS, INC.
Reel/Frame 071123/0153 →
Continuity (6)
Continuation
PCTUS2017039527
· Jun 27, 2017
Provisional Application
62489753
· Apr 25, 2017
Provisional Application
62355164
· Jun 27, 2016
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