IP Library › Granted Patent US 12,575,879
Granted Patent B2
US 12,575,879 · App. 17/824,720 · Granted Mar 17, 2026

Methods, apparatuses, and systems for the treatment of pulmonary disorders

Inventors: Jonathan Reuben Waldstreicher (West Orange, NJ); William Sanford Krimsky (Forest Hill, MD); Denise Marie Zarins (Saratoga, CA); Robert J. Beetel, III (Sunnyvale, CA); Paul Brian Friedrichs (Belmont, CA); Kevin James Taylor (San Mateo, CA); Roman Turovskiy (San Francisco, CA); Gary L. Long (Cincinnati, OH)
Assignee: Galvanize Therapeutics, Inc.
A61B18/1492A61B18/1206A61N1/06A61N1/327A61B2018/0016A61B2018/0022A61B2018/00267A61B2018/00541A61B2018/00577A61B2018/00642A61B2018/00648A61B2018/00678A61B2018/00702A61B2018/00791A61B2018/00839A61B2018/00875A61B2018/1435A61B2018/1467
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Quick Facts
Patent No.
US 12,575,879
App. No.
17/824,720
Granted
Mar 17, 2026
Kind
B2
Abstract

Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The system may be used to treat a variety of pulmonary diseases or disorders such as or associated with COPD (e.g., chronic bronchitis, emphysema), asthma, interstitial pulmonary fibrosis, cystic fibrosis, bronchiectasis, primary ciliary dyskinesia (PCD), acute bronchitis and/or other pulmonary diseases or disorders.

Claims (22)

1 . A system for modifying cells of a lung passageway of a patient, the system comprising:

a catheter comprising at least one electrode, wherein the at least one electrode is configured to be positioned within a lung passageway so as to transmit energy to an airway wall of the lung passageway; and

a generator in electrical communication with the at least one electrode, wherein the generator includes at least one energy delivery algorithm configured to provide an electric signal of the energy, wherein the energy modifies particular cells of the airway wall that remain intact so as to reduce secretion of mucus by the airway wall.

2 . The system of claim 1 , wherein the electric signal has a waveform comprising at least one energy packet, wherein each energy packet comprises a series of pulses.

3 . The system of claim 2 , wherein the series of pulses comprises biphasic pulses.

4 . The system of claim 1 , wherein the energy removes at least one cell in addition to modifying the particular cells.

5 . The system of claim 4 , wherein removal of the at least one cell comprises removal of cells from a collagen matrix structure within the airway which remains intact.

6 . The system of claim 4 , wherein removes comprises cell death.

7 . The system of claim 4 , wherein the at least one cell comprises at least one basal cell.

8 . The system of claim 1 , wherein modifying changes a particular functioning of the particular cells.

9 . The system of claim 1 , wherein the particular cells comprise abnormally functioning cells.

10 . The system of claim 1 , wherein the particular cells comprise ciliated pseudostratified columnar epithelial cells and/or goblet cells.

11 . The system of claim 1 , wherein the particular cells comprise submucosal glands.

12 . The system of claim 1 , wherein the energy penetrates an epithelial layer of the airway up to and including a basement membrane.

13 . The system of claim 1 , wherein the particular cells comprise the basement membrane and wherein modifying the particular cells comprises affecting the basement membrane so as to assist in remodeling the airway wall to reduce secretion of mucus by the airway wall.

14 . The system of claim 1 , wherein the particular cells comprise the basement membrane and wherein modifying the particular cells comprises stabilizing thickness of the basement membrane.

15 . The system of claim 1 , wherein the particular cells comprise the basement membrane and wherein modifying the particular cells comprises reducing thickness of the basement membrane.

16 . The system of claim 1 , wherein the particular cells comprise the basement membrane and wherein modifying the particular cells comprises reducing ability of other cells to cross the basement membrane.

17 . The system of claim 16 , wherein the other cells comprise neutrophils and/or inflammatory molecules.

18 . The system of claim 1 , wherein the generator includes at least one additional energy delivery algorithm configured to provide an electric signal of the energy which removes additional cells of the airway wall.

19 . The system of claim 18 , wherein the generator includes at least one additional energy delivery algorithm configured to provide an electric signal of the energy that causes cell removal of previously modified cells.

20 . The system of claim 1 , wherein the at least one electrode comprises a plurality of wires forming an expandable basket, wherein at least one of the plurality of wires acts as the at least one electrode.

Assignments (4)
SECURITY INTEREST Recorded Jan 13, 2025
From: GALVANIZE THERAPEUTICS, INC.
To: SYMBIOTIC CAPITAL AGENCY LLC
Reel/Frame 069879/0694 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 3, 2022
From: WALDSTREICHER, JONATHAN REUBEN; KRIMSKY, WILLIAM SANFORD; ZARINS, DENISE MARIE; BEETEL, ROBERT J., III; FRIEDRICHS, PAUL BRIAN; TAYLOR, KEVIN JAMES; TUROVSKIY, ROMAN; LONG, GARY L.
To: GALA THERAPEUTICS, INC.
Reel/Frame 061651/0312 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 3, 2022
From: GALA THERAPEUTICS, INC.
To: GALARY, INC.
Reel/Frame 061651/0584 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 3, 2022
From: GALARY, INC.
To: GALVANIZE THERAPEUTICS, INC.
Reel/Frame 061651/0595 →
Continuity (5)
Continuation 16227796 · Dec 20, 2018
Continuation PCTUS2017039527 · Jun 27, 2017
Provisional Application 62489753 · Apr 25, 2017
Provisional Application 62355164 · Jun 27, 2016
Related Publication 20220395323A1 · Dec 15, 2022
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