IP Library › Patent Application 18943741
Patent Application
App. No. 18/943,741

ANTIMICROBIAL ORGANOSILANES

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Quick Facts
Patent No.
US None
App. No.
18/943,741
Abstract

Organosilicon quaternary ammonium compounds, their formulations, including powdered and solid formulations, and methods of use to treat infections in humans and animals.

Claims (32)

1 . (canceled)

2 . A quaternary ammonium compound of Formula:

wherein

a is 1, 2, 3, 4, 5, 6, 7 or 8;

R 1 is C 6 -C 22 alkyl;

R 2 , R 3 , and R 4 are:

R 8 and R 9 are CH 2 OR 7 ;

R 7 is hydrogen;

X 1 is NR 17 ;

R 17 hydrogen;

X 4 is C 1 -C 8 alkanoyl;

R 16 is C 1 -C 4 alkyl; and

X − is an anion.

3 . The quaternary ammonium compound of claim 2 , wherein X − is selected from the group consisting of chloride, fluoride, iodide, bromide, hydroxide, chlorite, chlorate, formate, acetate, lactate, benzoate, methane sulfonate and salicylate anion.

4 . The quaternary ammonium compound of claim 2 , wherein the compound is a lyophilized powder.

5 . A pharmaceutical composition comprising a compound of claim 2 and a pharmaceutically acceptable excipient.

6 . The pharmaceutical composition of claim 5 , wherein the composition is suitable for topical delivery.

7 . The pharmaceutical composition of claim 5 , wherein the composition is in the form of a liquid, cream, gel, spray, foam, powder, paste, or solid.

8 . A quaternary ammonium compound, wherein the compound is

wherein:

X − is an anion.

9 . The quaternary ammonium compound of claim 8 , wherein X − is selected from the group consisting of chloride, fluoride, iodide, bromide, chlorite, chlorate, hydroxide, formate, acetate, lactate, benzoate, methane sulfonate and salicylate anion.

10 . The quaternary ammonium compound of claim 8 , wherein the compound is:

11 . The quaternary ammonium compound of claim 8 , wherein the compound is:

12 . The quaternary ammonium compound of claim 8 , wherein the compound is:

wherein X − is methane sulfonate.

13 . The quaternary ammonium compound of claim 8 , wherein the compound is:

wherein X − is methane sulfonate.

14 . The quaternary ammonium compound of claim 8 , wherein the compound is a lyophilized powder.

15 . A pharmaceutical composition comprising a compound of claim 8 and a pharmaceutically acceptable excipient.

16 . The pharmaceutical composition of claim 15 , wherein the composition is suitable for topical delivery.

17 . The pharmaceutical composition of claim 15 , wherein the composition is in the form of a liquid, cream, gel, spray, foam, powder, paste, or solid.