MONO- OR DI-SUBSTITUTED INDOLE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS
The present invention relates to mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
9 . A method of treating a Dengue viral infection in a subject in need thereof, comprising administering to the subject a compound selected from the group consisting of:
or a stereoisomer, pharmaceutically acceptable salt, solvate or polymorph thereof.
10 . The method of claim 9 , wherein said compound is in a crystalline form.
11 . The method of claim 9 , wherein said compound is in an amorphous form.
12 . The method of claim 9 , wherein said compound is in an un-solvated form.
13 . The method of claim 9 , wherein said compound is a pharmaceutically acceptable salt.
14 . The method of claim 9 , further comprising administering an additional therapeutic agent to the subject.
15 . The method of claim 14 , wherein said additional therapeutic agent is selected from an antiviral agent or dengue vaccine, or both.
16 . The method of claim 9 , wherein said compound is administered in the form of a pharmaceutical composition comprising the compound or the stereoisomer, pharmaceutically acceptable salt, solvate or polymorph thereof, and one or more pharmaceutically acceptable excipients, diluents or carriers.
17 . The method of claim 9 , wherein said compound is:
or a stereoisomer, pharmaceutically acceptable salt, solvate or polymorph thereof.
18 . The method of claim 9 , wherein said compound is:
or a stereoisomer, pharmaceutically acceptable salt, solvate or polymorph thereof.
19 . The method of claim 9 , wherein said compound is:
or a stereoisomer, pharmaceutically acceptable salt, solvate or polymorph thereof.
20 . The method of claim 9 , wherein said compound is:
or a stereoisomer, pharmaceutically acceptable salt, solvate or polymorph thereof.
21 . The method of claim 9 , wherein said compound is:
or a stereoisomer, pharmaceutically acceptable salt, solvate or polymorph thereof.
22 . The method of claim 9 , wherein said compound is:
or a stereoisomer, pharmaceutically acceptable salt, solvate or polymorph thereof.
23 . The method of claim 9 , wherein said compound is:
or a stereoisomer, pharmaceutically acceptable salt, solvate or polymorph thereof.
24 . The method of claim 9 , wherein said compound is:
or a stereoisomer, pharmaceutically acceptable salt, solvate or polymorph thereof.
25 . The method of claim 9 , wherein said compound is:
or a stereoisomer, pharmaceutically acceptable salt, solvate or polymorph thereof.
26 . The method of claim 9 , wherein said compound is:
or a stereoisomer, pharmaceutically acceptable salt, solvate or polymorph thereof.