SEROTONERGIC PSYCHEDELIC AGENT FOR TREATING SELECTIVE MUTISM
Methods and compositions for treating or alleviating symptoms of selective mutism in a human subject with a serotonergic psychedelic agent alone or in combination with N-acetylcysteine are provided.
1 . A method for alleviating one or more symptoms of selective mutism (SM) in a human, said method comprising administering to a human suffering from SM a serotonergic psychedelic agent.
2 . The method of claim 1 wherein the serotonergic psychedelic agent is a psilocibe-derived agent.
3 . The method of claim 2 wherein the psilocibe-derived agent is psilocybin or psilocin or a salt, conjugate or ester thereof.
4 . The method of claim 1 further comprising administering to the human N-acetylcysteine (NAC).
5 . The method of claim 1 wherein the human is a child suffering from SM.
6 . The method of claim 1 wherein one or more behaviors associated with SM is selected from a persistent failure to speak in select social contexts, reliance on non-verbal cues in lieu of talking, fear of social embarrassment, social isolation and withdrawal, clinging, compulsive traits, negativism, temper tantrums, and mild oppositional behavior is decreased.
7 . A composition comprising a serotonergic psychedelic agent in an amount effective in alleviating one or more symptoms of SM.
8 . The composition of claim 7 wherein the serotonergic psychedelic agent is a psilocibe-derived agent.
9 . The composition of claim 8 wherein the psilocibe-derived agent is psilocybin or psilocin or a salt, conjugate or ester thereof.
10 . The composition claim 7 further comprising human N-acetylcysteine (NAC).
11 . The composition of claim 7 formulated for administration to a child suffering from SM.