METHOD OF ESCALATING SOTALOL HYDROCHLORIDE DOSING
The present invention provides novel methods of initiating and escalating sotalol hydrochloride in patients in need thereof.
1 . A method of escalating sotalol hydrochloride, dosing comprising:
a. escalating an existing sotalol concentration of a subject to a higher level by administering an intravenous (IV) dose of 105 mg sotalol hydrochloride over a period of 1 hour to the subject, wherein the subject had symptomatic atrial fibrillation or atrial flutter and is currently in sinus rhythm; and
b. after completion of the IV dose, administering oral dosing of one or more oral dose of sotalol hydrochloride to the subject in an amount of 160 mg;
wherein the subject is discharged from the hospital 24 hours after IV initiation.
2 . The method of claim 1 , wherein the oral dosing is initiated 4-12 hours after completion of the IV dose.
3 . (canceled)
4 . The method of claim 1 , wherein the oral dosing is initiated 4-6 hours after completion of the IV dose.
5 . The method of claim 1 , wherein the oral dosing is initiated 6-12 hours after completion of the IV dose.
6 . The method of claim 2 , wherein one or more of the oral doses are administered at an interval of 12-48 hours from initiation of the oral dosing.
7 . The method of claim 4 , wherein one or more of the oral doses are administered at an interval of 12-24 hours from initiation of the oral dosing.
8 . The method of claim 5 , wherein one or more of the oral doses are administered at an interval of 24-48 hours from initiation of the oral dosing.
9 . The method of claim 1 , wherein:
the oral dosing is initiated 4 hours after completion of the IV dose; and
one or more of the oral doses are administered at an interval of 12 hours from initiation of the oral dosing.
10 . The method of claim 1 , wherein:
the oral dosing is initiated 6 hours after completion of the IV dose; and
one or more of the oral doses are administered at an interval of 24 hours from initiation of the oral dosing.
11 . The method of claim 1 , wherein:
the oral dosing is initiated 12 hours after completion of the IV dose; and
one or more of the oral doses are administered at an interval of 48 hours from initiation of the oral dosing.
12 . The method of claim 1 , wherein the subject is receiving 120 mg oral sotalol hydrochloride therapy and the IV dose is administered to escalate the existing sotalol concentration of the subject to a higher concentration before administering the 160 mg oral dose of sotalol hydrochloride.