EFFECTS OF LYSERGIC ACID DIETHYLAMIDE (LSD) AND OF LSD ANALOGS TO ASSIST PSYCHOTHERAPY FOR GENERALIZED ANXIETY DISORDER OR OTHER ANXIETY NOT RELATED TO LIFE-THREATENING ILLNESS
A method of treating anxiety disorders specifically not associated with causes such as a life-threatening serious somatic illness, by administering a psychedelic to an individual, and treating anxiety and specifically causing reductions in the rating scale score measures of anxiety (STAI global or state or trait anxiety) and/or measures of depression (HDRS or BDI scores) and/or measures of general psychological distress (SCL-90 ratings) in the patient for several weeks beyond administration of the psychedelic. A method of treating anxiety, by administering a psychedelic (preferably LSD) to an individual having anxiety not associated with causes such as a life-threatening serious somatic illness, and inducing positive acute drug effects and positive long-term therapeutic effects in the individual.
1 .- 17 . (canceled)
18 . A method of treating generalized anxiety disorder in an individual comprising:
administering 25-400 μg of LSD, or a salt thereof, wherein the administration of 25-400 μg of LSD, or a salt thereof, results in a reduced STAI global score.
19 . The method of claim 18 , wherein a second dose of LSD, or a salt thereof, is administered four to five weeks after said administering step.
20 . The method of claim 18 , when the subject also has depression or low mood associated or co-present with the anxiety.
21 . The method of claim 18 , wherein the administration of LSD, or a salt thereof, results in reduced psychological distress.
22 . The method of claim 18 , wherein the administration of LSD, or a salt thereof, results in an increased quality of life in the individual.
23 . The method of claim 18 , further including the step of providing psychotherapy to the individual on separate days before and after administration of LSD, or a salt thereof.
24 . The method of claim 23 , wherein the administration of LSD, or a salt thereof, enhances the therapeutic effect of the psychotherapy.
25 . The method of claim 18 , wherein the LSD, or a salt thereof, is administered in the presence of a therapist for 12 hours in a quiet room.
26 . The method of claim 25 , wherein the individual is lying in a bed or sitting in a chair and listening to music.
27 . The method of claim 19 , wherein the second dose of LSD, or a salt thereof, is administered in the presence of a therapist for 12 hours in a quiet room.
28 . The method of claim 27 , wherein the individual is lying in a bed or sitting in a chair and listening to music.
29 . The method of claim 18 , wherein the individual was tapered off an antidepressant at least two weeks before administration of LSD, or a salt thereof.
30 . The method of claim 18 , wherein the STAI global score is reduced by 10-points in about four weeks or greater after administration of LSD, or a salt thereof.
31 . The method of claim 18 , wherein the STAI global score is reduced by 10-points in about ten weeks or greater after administration of LSD, or a salt thereof.
32 . The method of claim 18 , wherein the STAI global score is reduced by 20-points in about ten weeks or greater after administration of LSD, or a salt thereof.