IP Library › Granted Patent US 12,390,237
Granted Patent B2
US 12,390,237 · App. 19/020,361 · Granted Aug 19, 2025

Neurovascular clot retrieving system

Inventors: Thanh Van Nguyen (Irvine, CA); Rajan Hansji (Irvine, CA); Duy Nguyen (Irvine, CA)
Assignee: Cerebrova KP Medical, Inc.
A61B17/221A61B2017/00778A61B2017/00862A61B2017/2212
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Quick Facts
Patent No.
US 12,390,237
App. No.
19/020,361
Filed
Jan 14, 2025
Granted
Aug 19, 2025
Kind
B2
Art Unit
3771
USPC
606/127
Abstract

Various embodiments of devices and methods of use are provided. The device can include a catheter shaft having a proximal end and a distal end. The device can include an extractor. The extractor can include engagement panels located at a first longitudinal location and engagement panels located at a second longitudinal location. The extractor can include a spacer between engagement panels located at the first longitudinal location and engagement panels located at the second longitudinal location. The device can include a sheath, wherein the extractor comprises a collapsed state within the sheath for delivery and an expanded state within a blood vessel. In the expanded state, the engagement panels are configured to engage material between engagement panels located at a first longitudinal location and engagement panels located at a second longitudinal location.

Claims (32)

1. A device for removing material from a patient, the device comprising:

an extractor formed from one continuous wire, the extractor comprising a first array of engagement panels located at a first longitudinal location formed from the one continuous wire, wherein the first array of engagement panels is configured to extend radially outward from a first coiled eyelet formed from the one continuous wire when expanded within a blood vessel,

a second array of engagement panels located at a second longitudinal location formed from the one continuous wire, wherein the second array of engagement panels is configured to extend radially outward from a second coiled eyelet formed from the one continuous wire when expanded within the blood vessel,

a third array of engagement panels located at a third longitudinal location formed from the one continuous wire, wherein the third array of engagement panels is configured to extend radially outward from a third coiled eyelet formed from the one continuous wire when expanded within the blood vessel, the first longitudinal location is spaced apart from the second longitudinal location, wherein the second longitudinal location is spaced apart from the third longitudinal location,

wherein when expanded within the blood vessel, the first array of engagement panels is configured to be positioned distal to a thrombus, the second array of engagement panels is configured to be positioned within the thrombus, and the third array of engagement panels is configured to be positioned proximal to the thrombus,

wherein when expanded within the blood vessel, the first array of engagement panels, the second array of engagement panels, and the third array of engagement panels are configured to engage the thrombus between the first array of engagement panels, the second array of engagement panels, and the third array of engagement panels,

wherein upon retraction of the extractor to remove the thrombus, the engagement panels are configured to act independently and do not stretch or elongate under tension thus securing the thrombus during transit.

2. The device of claim 1 , wherein each engagement panel comprises a quadrant of a circle.

3. The device of claim 1 , wherein each engagement panel comprises a fan shape.

4. The device of claim 1 , wherein each engagement panel comprises two legs that extend radially outward from the respective coiled eyelet.

5. The device of claim 1 , wherein each engagement panel comprises an arc configured to scrape along a wall of the blood vessel.

6. The device of claim 5 , wherein the arc comprises a smooth and atraumatic edge.

7. The device of claim 1 , wherein the first array of engagement panels located at the first longitudinal location form a relatively complete circle configured to be in contact with the blood vessel.

8. The device of claim 1 , wherein the first array engagement panels at the first longitudinal location are configured to contact more than 80% of a circumference of a wall of the blood vessel.

9. The device of claim 1 , wherein the first array engagement panels at the first longitudinal location are configured to contact more than 90% of a circumference of a wall of the blood vessel.

10. The device of claim 1 , wherein the first array of engagement panels located at the first longitudinal location are configured form a generally circular profile similar to a circumference of a wall of the blood vessel.

11. The device of claim 1 , further comprising a distal member distal to the first array of engagement panels, wherein the distal member is configured to prevent distal migration of the thrombus.

12. The device of claim 1 , wherein the first coiled eyelet, the second coiled eyelet, and the third coiled eyelet are configured to receive a catheter shaft or core wire.

13. A method for removing material from a patient, the method comprising:

expanding an extractor within a blood vessel, wherein the extractor is formed from one continuous wire, the extractor comprising a first array of engagement panels located at a first longitudinal location formed from the one continuous wire, wherein the first array of engagement panels extends radially outward from a first coiled eyelet formed from the one continuous wire when expanded within the blood vessel,

a second array of engagement panels located at a second longitudinal location formed from the one continuous wire, wherein the second array of engagement panels extends radially outward from a second coiled eyelet formed from the one continuous wire when expanded within the blood vessel,

a third array of engagement panels located at a third longitudinal location formed from the one continuous wire, wherein the third array of engagement panels extends radially outward from a third coiled eyelet formed from the one continuous wire when expanded within the blood vessel, wherein the first location is spaced apart from the second location, wherein the second location is spaced apart from the third location,

wherein when expanded within the blood vessel, the first array of engagement panels is positioned distal to a thrombus, the second array of engagement panels is positioned within the thrombus, wherein the third array of engagement panels is positioned proximal to the thrombus,

wherein when expanded within the blood vessel, the first array of engagement panels, the second array of engagement panels, and the third array of engagement panels engage the thrombus between the first array of engagement panels, the second array of engagement panels, and the third array of engagement panels,

wherein upon retraction of the extractor to remove the thrombus, the engagement panels act independently and do not stretch or elongate under tension thus securing the thrombus during transit.

14. The method of claim 13 , wherein the first array of engagement panels located at the first longitudinal location, the second array of engagement panels located at the second longitudinal location, and the third array of engagement panels located at the third longitudinal location engage the thrombus while additional engagement panels are collapsed within a sheath.

15. The method of claim 13 , wherein the extractor is pulled proximally and the first array of engagement panels, the second array of engagement panels, and the third array of engagement panels scrape along a surface of the blood vessel.

16. The method of claim 13 , wherein the blood vessel comprises a cerebral blood vessel.

17. The method of claim 13 , wherein the thrombus is located within the middle cerebral artery.

18. The method of claim 13 , wherein the extractor comprises a column strength to move longitudinally within the blood vessel.

19. The method of claim 13 , wherein the first array of engagement panels located at the first longitudinal location, the second array of engagement panels located at the second longitudinal location, and the third array of engagement panels located at the third longitudinal location retain their shape when pulled.

20. The method of claim 13 , wherein the extractor is expanded approximately equal to a diameter of the blood vessel.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 17, 2025
From: NGUYEN, THANH VAN; HANSJI, RAJAN; NGUYEN, DUY
To: KP MEDCURE, INC.
Reel/Frame 069922/0478 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 17, 2025
From: KP MEDCURE, INC.
To: CEREBROVA KP MEDICAL, INC.
Reel/Frame 069922/0426 →
Continuity (4)
Continuation 18583727 · Feb 21, 2024
Provisional Application 63617321 · Jan 3, 2024
Provisional Application 63610696 · Dec 15, 2023
Related Publication 20250195095A1 · Jun 19, 2025
References Cited (245)
US 3506011A · Silverman · 1970 [cited by applicant]
US 4727873A · Mobin-Uddin · 1988 [cited by applicant]
US 5011488A · Ginsburg · 1991 [cited by applicant]
US 5102415A · Guenther et al. · 1992 [cited by applicant]
US 5135484A · Wright · 1992 [cited by applicant]
US 5846251A · Hart · 1998 [cited by applicant]
US 5868708A · Hart · 1999 [cited by applicant]
US 5895398A · Wensel et al. · 1999 [cited by applicant]
US 5935139A · Bates · 1999 [cited by applicant]
US 5947985A · Imran · 1999 [cited by applicant]
US 6036720A · Abrams et al. · 2000 [cited by applicant]
US 6066149A · Samson et al. · 2000 [cited by applicant]
US 6126635A · Simpson et al. · 2000 [cited by applicant]
US 6165196A · Stack et al. · 2000 [cited by applicant]
US 6179859B1 · Bates et al. · 2001 [cited by applicant]
US 6210370B1 · Chi-Sing et al. · 2001 [cited by applicant]
US 6221006B1 · Dubrul et al. · 2001 [cited by applicant]
US 6264663B1 · Cano · 2001 [cited by applicant]
US 6270477B1 · Bagaoisan et al. · 2001 [cited by applicant]
US 6319242B1 · Patterson et al. · 2001 [cited by applicant]
US 6391044B1 · Yadav et al. · 2002 [cited by applicant]
US 6432122B1 · Gilson et al. · 2002 [cited by applicant]
US 6458139B1 · Palmer et al. · 2002 [cited by applicant]
US 6569181B1 · Burns · 2003 [cited by applicant]
US 6605102B1 · Mazzocchi et al. · 2003 [cited by applicant]
US 6620182B1 · Khosravi et al. · 2003 [cited by applicant]
US 6635070B2 · Leeflang et al. · 2003 [cited by applicant]
US 6645224B2 · Gilson et al. · 2003 [cited by applicant]
US 6663650B2 · Sepetka et al. · 2003 [cited by applicant]
US 6824545B2 · Sepetka et al. · 2004 [cited by applicant]
US 6840950B2 · Stanford et al. · 2005 [cited by applicant]
US 6945977B2 · Demarais et al. · 2005 [cited by applicant]
US 7094249B1 · Broome et al. · 2006 [cited by applicant]
US 7179273B1 · Palmer et al. · 2007 [cited by applicant]
US 7220271B2 · Clubb et al. · 2007 [cited by applicant]
US 7232432B2 · Fulton et al. · 2007 [cited by applicant]
US 7491210B2 · Dubrul et al. · 2009 [cited by applicant]
US 7621870B2 · Berrada et al. · 2009 [cited by applicant]
US 7662165B2 · Gilson et al. · 2010 [cited by applicant]
US 7766921B2 · Sepetka et al. · 2010 [cited by applicant]
US 7780696B2 · Daniel et al. · 2010 [cited by applicant]
US 7785342B2 · Gilson et al. · 2010 [cited by applicant]
US 7901426B2 · Gilson et al. · 2011 [cited by applicant]
US 7914549B2 · Morsi · 2011 [cited by applicant]
US 8070769B2 · Broome · 2011 [cited by applicant]
US 8092486B2 · Berrada et al. · 2012 [cited by applicant]
US 8236024B2 · Stanford et al. · 2012 [cited by applicant]
US 8252017B2 · Paul, Jr. et al. · 2012 [cited by applicant]
US 8255193B2 · Humphrey et al. · 2012 [cited by applicant]
US 8298252B2 · Krolik et al. · 2012 [cited by applicant]
US 8313503B2 · Cully et al. · 2012 [cited by applicant]
US 8337520B2 · Cully et al. · 2012 [cited by applicant]
US 8361095B2 · Osborne · 2013 [cited by applicant]
US 8388644B2 · Parker · 2013 [cited by applicant]
US 8444661B2 · Nair et al. · 2013 [cited by applicant]
US 8460335B2 · Carpenter · 2013 [cited by applicant]
US 8475487B2 · Bonnette et al. · 2013 [cited by applicant]
US 8491623B2 · Vogel et al. · 2013 [cited by applicant]
US 8545526B2 · Martin et al. · 2013 [cited by applicant]
US 8613717B2 · Aklog et al. · 2013 [cited by applicant]
US 8657849B2 · Parker · 2014 [cited by applicant]
US 8696622B2 · Fiorella · 2014 [cited by applicant]
US 8734374B2 · Aklog et al. · 2014 [cited by applicant]
US 8771289B2 · Mohiuddin et al. · 2014 [cited by applicant]
US 8777976B2 · Brady et al. · 2014 [cited by applicant]
US 8795305B2 · Martin et al. · 2014 [cited by applicant]
US 8795322B2 · Cully et al. · 2014 [cited by applicant]
US 8801748B2 · Martin · 2014 [cited by applicant]
US 8864792B2 · Eckhouse et al. · 2014 [cited by applicant]
US 8919389B2 · Gries · 2014 [cited by applicant]
US 8926642B2 · Nelson · 2015 [cited by applicant]
US 8932319B2 · Martin et al. · 2015 [cited by applicant]
US 8948848B2 · Merhi · 2015 [cited by applicant]
US 8956384B2 · Berrada et al. · 2015 [cited by applicant]
US 8968330B2 · Rosenbluth et al. · 2015 [cited by applicant]
US 8998944B2 · Thornton · 2015 [cited by applicant]
US 9254371B2 · Martin et al. · 2016 [cited by applicant]
US 9283066B2 · Hopkins et al. · 2016 [cited by applicant]
US 9301769B2 · Brady et al. · 2016 [cited by applicant]
US 9308007B2 · Cully et al. · 2016 [cited by applicant]
US 9358022B2 · Morsi · 2016 [cited by applicant]
US 9398946B2 · Valaie · 2016 [cited by applicant]
US 9408620B2 · Rosenbluth et al. · 2016 [cited by applicant]
US 9427244B2 · Lund-Clausen et al. · 2016 [cited by applicant]
US 9463036B2 · Brady et al. · 2016 [cited by applicant]
US 9526864B2 · Quick · 2016 [cited by applicant]
US 9579116B1 · Nguyen et al. · 2017 [cited by applicant]
US 9636206B2 · Nguyen et al. · 2017 [cited by applicant]
US 9744024B2 · Nguyen et al. · 2017 [cited by applicant]
US 9844386B2 · Nguyen et al. · 2017 [cited by applicant]
US 9931495B2 · Aboytes · 2018 [cited by applicant]
US 9999493B2 · Nguyen et al. · 2018 [cited by applicant]
US 10045790B2 · Cox et al. · 2018 [cited by applicant]
US 10070879B2 · Nguyen et al. · 2018 [cited by applicant]
US 10076347B2 · Sepetka et al. · 2018 [cited by applicant]
US 10143482B2 · Nguyen et al. · 2018 [cited by applicant]
US 10238482B2 · Nguyen et al. · 2019 [cited by applicant]
US 10271863B2 · Marks et al. · 2019 [cited by applicant]
US 10292723B2 · Brady · 2019 [cited by applicant]
US 10314600B2 · Morsi · 2019 [cited by applicant]
US 10376275B2 · Nguyen et al. · 2019 [cited by applicant]
US 10456236B2 · Nguyen et al. · 2019 [cited by applicant]
US 10512479B2 · Nguyen et al. · 2019 [cited by applicant]
US 10517708B2 · Gorochow · 2019 [cited by applicant]
US 10660645B2 · Allen et al. · 2020 [cited by applicant]
US 10687834B2 · Follmer et al. · 2020 [cited by applicant]
US 10716586B2 · Krolik et al. · 2020 [cited by applicant]
US 10939931B2 · Grandfield et al. · 2021 [cited by applicant]
US 11090057B2 · Allen et al. · 2021 [cited by applicant]
US 11259820B2 · Walzman · 2022 [cited by applicant]
US 11471175B2 · Nguyen et al. · 2022 [cited by applicant]
US 11490913B2 · Nguyen et al. · 2022 [cited by applicant]
US 11504150B2 · Marks et al. · 2022 [cited by applicant]
US 11510691B2 · Nguyen et al. · 2022 [cited by applicant]
US 11793531B2 · Nguyen et al. · 2023 [cited by applicant]
US 12029443B2 · Nguyen et al. · 2024 [cited by applicant]
US 12226112B1 · Nguyen · 2025 [cited by examiner]
US 20020095171A1 · Belef · 2002 [cited by applicant]
US 20020123765A1 · Sepetka et al. · 2002 [cited by applicant]
US 20020147458A1 · Hiblar et al. · 2002 [cited by applicant]
US 20020169474A1 · Kusleika et al. · 2002 [cited by applicant]
US 20030176884A1 · Berrada et al. · 2003 [cited by applicant]
US 20030216770A1 · Persidsky et al. · 2003 [cited by applicant]
US 20040039411A1 · Gilson et al. · 2004 [cited by applicant]
US 20040073198A1 · Gilson et al. · 2004 [cited by applicant]
US 20040087971A1 · Arnott · 2004 [cited by applicant]
US 20040098025A1 · Sepetka et al. · 2004 [cited by applicant]
US 20040098033A1 · Leeflang et al. · 2004 [cited by applicant]
US 20050085826A1 · Nair et al. · 2005 [cited by applicant]
US 20050085846A1 · Carrison et al. · 2005 [cited by applicant]
US 20060025804A1 · Krolik et al. · 2006 [cited by applicant]
US 20060155305A1 · Freudenthal et al. · 2006 [cited by applicant]
US 20060212062A1 · Farascioni · 2006 [cited by applicant]
US 20060282111A1 · Morsi · 2006 [cited by applicant]
US 20070010702A1 · Wang et al. · 2007 [cited by applicant]
US 20070088382A1 · Bei et al. · 2007 [cited by applicant]
US 20070093744A1 · Elmaleh · 2007 [cited by applicant]
US 20070112374A1 · Paul et al. · 2007 [cited by applicant]
US 20070191866A1 · Palmer et al. · 2007 [cited by applicant]
US 20070282303A1 · Nash et al. · 2007 [cited by applicant]
US 20080167678A1 · Morsi · 2008 [cited by applicant]
US 20080262487A1 · Wensel et al. · 2008 [cited by applicant]
US 20090292307A1 · Razack · 2009 [cited by applicant]
US 20100211095A1 · Carpenter · 2010 [cited by applicant]
US 20100249815A1 · Jantzen et al. · 2010 [cited by applicant]
US 20100268264A1 · Bonnette et al. · 2010 [cited by applicant]
US 20100268265A1 · Krolik et al. · 2010 [cited by applicant]
US 20110125181A1 · Brady et al. · 2011 [cited by applicant]
US 20110166586A1 · Sepetka et al. · 2011 [cited by applicant]
US 20110196414A1 · Porter et al. · 2011 [cited by applicant]
US 20120172915A1 · Fifer et al. · 2012 [cited by applicant]
US 20120197285A1 · Martin et al. · 2012 [cited by applicant]
US 20120271403A1 · Gries · 2012 [cited by applicant]
US 20120310251A1 · Sepetka et al. · 2012 [cited by applicant]
US 20120330346A1 · Frimerman · 2012 [cited by applicant]
US 20120330350A1 · Jones et al. · 2012 [cited by applicant]
US 20130102996A1 · Strauss · 2013 [cited by applicant]
US 20130144326A1 · Brady et al. · 2013 [cited by applicant]
US 20130178891A1 · Russell et al. · 2013 [cited by applicant]
US 20130184738A1 · Laroya et al. · 2013 [cited by applicant]
US 20130184741A1 · Laroya et al. · 2013 [cited by applicant]
US 20130197567A1 · Brady et al. · 2013 [cited by applicant]
US 20130238009A9 · Hopkins et al. · 2013 [cited by applicant]
US 20130267993A1 · Carpenter · 2013 [cited by applicant]
US 20130338703A1 · Hansen et al. · 2013 [cited by applicant]
US 20130345739A1 · Brady et al. · 2013 [cited by applicant]
US 20140005712A1 · Martin · 2014 [cited by applicant]
US 20140005717A1 · Martin et al. · 2014 [cited by applicant]
US 20140046358A1 · Cully et al. · 2014 [cited by applicant]
US 20140052103A1 · Cully et al. · 2014 [cited by applicant]
US 20140128894A1 · Sepetka et al. · 2014 [cited by applicant]
US 20140155908A1 · Rosenbluth et al. · 2014 [cited by applicant]
US 20140249566A1 · Quinn et al. · 2014 [cited by applicant]
US 20140249568A1 · Adams et al. · 2014 [cited by applicant]
US 20140276403A1 · Follmer et al. · 2014 [cited by applicant]
US 20140276922A1 · McLain et al. · 2014 [cited by applicant]
US 20140277013A1 · Sepetka et al. · 2014 [cited by applicant]
US 20140350593A1 · Laroya et al. · 2014 [cited by applicant]
US 20140371781A1 · Morgan · 2014 [cited by applicant]
US 20150005781A1 · Lund-Clausen et al. · 2015 [cited by applicant]
US 20150018929A1 · Martin et al. · 2015 [cited by applicant]
US 20150088190A1 · Jensen · 2015 [cited by applicant]
US 20150196380A1 · Berrada et al. · 2015 [cited by applicant]
US 20150265299A1 · Cooper et al. · 2015 [cited by applicant]
US 20150297251A1 · Sos · 2015 [cited by applicant]
US 20150306311A1 · Pinchuk et al. · 2015 [cited by applicant]
US 20160022290A1 · Johnson et al. · 2016 [cited by applicant]
US 20160022291A1 · Johnson et al. · 2016 [cited by applicant]
US 20160022292A1 · Stigall et al. · 2016 [cited by applicant]
US 20160038271A1 · Johnsen et al. · 2016 [cited by applicant]
US 20160113666A1 · Quick et al. · 2016 [cited by applicant]
US 20160143721A1 · Rosenbluth et al. · 2016 [cited by applicant]
US 20160192953A1 · Brady · 2016 [cited by applicant]
US 20160256180A1 · Vale et al. · 2016 [cited by applicant]
US 20170035445A1 · Nguyen et al. · 2017 [cited by applicant]
US 20170086960A1 · Nguyen et al. · 2017 [cited by applicant]
US 20170143359A1 · Nguyen et al. · 2017 [cited by applicant]
US 20170224366A1 · Nguyen et al. · 2017 [cited by applicant]
US 20170259042A1 · Nguyen et al. · 2017 [cited by applicant]
US 20180055619A1 · Nguyen et al. · 2018 [cited by applicant]
US 20180125512A1 · Nguyen et al. · 2018 [cited by applicant]
US 20180296315A1 · Nguyen et al. · 2018 [cited by applicant]
US 20190015122A1 · Nguyen et al. · 2019 [cited by applicant]
US 20190021750A1 · Heilman · 2019 [cited by examiner]
US 20190099194A1 · Nguyen et al. · 2019 [cited by applicant]
US 20190142445A1 · Morsi · 2019 [cited by applicant]
US 20190216589A1 · Nguyen et al. · 2019 [cited by applicant]
US 20200029985A1 · Nguyen et al. · 2020 [cited by applicant]
US 20200197031A1 · Nguyen et al. · 2020 [cited by applicant]
US 20200222171A1 · Nguyen et al. · 2020 [cited by applicant]
US 20210128185A1 · Nguyen et al. · 2021 [cited by applicant]
US 20210307767A1 · Gifford, III et al. · 2021 [cited by applicant]
US 20230066304A1 · Nguyen et al. · 2023 [cited by applicant]
US 20230103647A1 · Nguyen et al. · 2023 [cited by applicant]
US 20230285040A1 · Cunniffe et al. · 2023 [cited by applicant]
US 20240032954A1 · Nguyen et al. · 2024 [cited by applicant]
US 20240173045A1 · Nguyen et al. · 2024 [cited by applicant]
US 20240293134A1 · Nguyen et al. · 2024 [cited by applicant]
CN 102036611 · 2011 [cited by applicant]
CN 103841905 · 2014 [cited by applicant]
CN 104042304 · 2014 [cited by applicant]
CN 113440214 · 2021 [cited by applicant]
EP 1221307 · 2002 [cited by applicant]
EP 3539486 · 2019 [cited by applicant]
EP 3681418 · 2020 [cited by applicant]
EP 3718492 · 2020 [cited by applicant]
FR 2694687 · 1994 [cited by applicant]
JP 2011508635 · 2011 [cited by applicant]
WO WO9939648 · 1999 [cited by applicant]
WO WO0236025 · 2002 [cited by applicant]
WO WO03077799 · 2003 [cited by applicant]
WO WO2006138391 · 2006 [cited by applicant]
WO WO2007047818 · 2007 [cited by applicant]
WO WO2008070996 · 2008 [cited by applicant]
WO WO2009055782 · 2009 [cited by applicant]
WO WO2009086482 · 2009 [cited by applicant]
WO WO2015079401 · 2015 [cited by applicant]
WO WO2017024258 · 2017 [cited by applicant]
WO WO2018148174 · 2018 [cited by applicant]
WO WO2021092235 · 2021 [cited by applicant]
WO WO2022236265 · 2022 [cited by applicant]
US 8,668,714 B2, 03/2014, Cully et al. (withdrawn) [cited by applicant]
Invitation to Pay Additional Fees dated May 20, 2024 in PCT/US2024/016740 in 3 pages. [cited by applicant]
Tendency Definition and Meaning Britannica Dictionary; 4 pages (2024). [cited by applicant]
International Search Report and Written Opinion in PCT/US2024/016740 dated Aug. 27, 2024; 29 pages. [cited by applicant]