IP Library › Patent Application 19030447
Patent Application
App. No. 19/030,447

SYSTEMS AND METHODS FOR TREATMENTS OF AN EYE WITH A PHOTOSENSITIZER

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Quick Facts
Patent No.
US None
App. No.
19/030,447
Abstract

A formulation for an eye treatment includes a photosensitizer and a permeability enhancing composition. The permeability enhancing composition includes one or more permeability enhancers. The permeability enhancing composition has a hydrophilic and lipophilic balance increases a permeability of an area of the eye for the photosensitizer. The hydrophilic and lipophilic balance can be characterized by a Hydrophile-Lipophile Balance (HLB) number. For example, the area of the eye may include a corneal epithelium, the photosensitizer may include riboflavin, and the permeability enhancing composition may have a corresponding HLB number between approximately 12.6 and approximately 14.6.

Claims (7)

1 . A method for treating corneal damage associated with a pathogen infection in an eye, comprising:

identifying an eye infected by a pathogen;

applying an eye drop formulation to an area of the eye infected by the pathogen, the formulation including:

a photosensitizer;

one or more non-ionic permeability enhancers; and

at least one additive selected from the group consisting of iron, copper, manganese, chromium, vanadium, aluminum, cobalt, mercury, cadmium, nickel, arsenic, 2,3-butanedione, and folic acid; and

delivering a dose of illumination having a fluence rate ranging from about 15 mW/cm 2 to about 45 mW/cm 2 in combination with pulsed oxygen to the area of the eye thereby photoactivating the photosensitizer and cross-linking corneal tissue at a depth that does not damage endothelium.