TRANSFER SYSTEM FOR USE IN A PHARMACEUTICAL BARRIER SYSTEM, IN PARTICULAR AN ISOLATOR, BETA COMPONENT FOR USE IN A TRANSFER SYSTEM, BARRIER SYSTEM, IN PARTICULAR AN ISOLATOR, AND PRODUCTION FACILITY
The invention relates to a transfer system (1) for use in a barrier system (2) and to a beta component (8) for use in a transfer system (1) and to a barrier system (2) and to a production facility (3).
1 . A transfer system ( 1 ) for a barrier system, the barrier system comprising a sterile isolation region ( 4 ) which is separated from a non-sterile operating region ( 6 ) by a partition ( 5 ), the transfer system ( 1 ) configured to transfer objects from the operating region ( 6 ) to the isolation region ( 4 ) and vice versa and the transfer system ( 1 ) comprising an alpha component ( 7 ) and a beta component ( 8 ), the alpha component ( 7 ) having an alpha flange ( 9 ) for connection to the partition ( 5 ) and an openable and closable alpha closure unit ( 10 ), the beta component ( 8 ) having a beta flange ( 37 ) and a removable beta closure unit for coupling to the alpha component ( 7 ), the beta component ( 8 ) further having a beta container ( 11 ) with a receiving space ( 12 ), wherein in the receiving space ( 12 ) of the beta component ( 8 ) there is arranged a magazine device ( 13 ) which comprises at least two receptacles ( 14 ) for objects ( 19 ), the objects ( 19 ) being intended to be transferred from the receiving space ( 12 ), through the beta flange ( 37 ) and to the isolation region ( 4 ), the magazine device ( 13 ) configured such that one of the receptacles ( 14 ) can be positioned in a removal position ( 16 ) each time so that, in the removal position ( 16 ), the objects ( 19 ) received in the receptacle ( 14 ) are positioned so as to be removed through the beta flange ( 37 ) and the alpha flange ( 9 ) and transferred to the isolation region ( 4 ).
2 . A beta component ( 8 ) for use in a transfer system ( 1 ) for a barrier system, the barrier system comprising a sterile isolation region ( 4 ) which is separated from a non-sterile operating region ( 6 ) by a partition ( 5 ), the transfer system ( 1 ) being configured to transfer objects from the operating region ( 6 ) to the isolation region ( 4 ) and vice versa and the transfer system ( 1 ) comprising an alpha component ( 7 ) and a beta component ( 8 ), the alpha component ( 7 ) having an alpha flange ( 9 ) which is connected to the partition ( 5 ) and has an openable and closable alpha closure unit ( 10 ), the beta component ( 8 ) having a beta flange ( 37 ) and a removable beta closure unit for coupling to the alpha component ( 7 ), the beta component ( 8 ) further having a beta container ( 11 ) with a receiving space ( 12 ), wherein in the receiving space ( 12 ) of the beta component ( 8 ) there is arranged a magazine device ( 13 ) which comprises at least two receptacles ( 14 ) for objects ( 19 ), the objects ( 19 ) being intended to be transferred from the receiving space ( 12 ), through the beta flange ( 37 ) and to the isolation region ( 4 ), the magazine device ( 13 ) configured such that one of the receptacles ( 14 ) can be positioned in a removal position ( 16 ) so that, in the removal position ( 16 ), the objects ( 19 ) received in the receptacle ( 14 ) are arranged for removal through the beta flange ( 37 ).
3 . The transfer system ( 1 ) according to claim 1 , wherein the beta component ( 8 ) comprises a connection ( 26 ) for a sterilization medium, by which a sterilization medium can be supplied to the receiving space ( 12 ) in order to sterilize said receiving space and any objects ( 19 ) located therein.
4 . The transfer system ( 1 ) according to claim 1 , wherein the beta component ( 8 ) comprises a collecting basin ( 28 ) for sterilization medium or its condensate and a bottom ( 29 ) of the collecting basin ( 28 ) has a gradient ( 30 ) toward a drain ( 27 ).
5 . The transfer system ( 1 ) according to claim 1 , wherein the magazine device ( 13 ) is designed to move the receptacles ( 14 ) of the magazine device ( 13 ) on a simple closed curve ( 39 ) in order to move them into or out of the removal position ( 16 ).
6 . The transfer system ( 1 ) according to claim 1 , wherein the magazine device ( 13 ) is configured to rotate the receptacles ( 14 ) of the magazine device ( 13 ) about an axis of rotation ( 38 ) in order to move them into or out of the removal position ( 16 ).
7 . The transfer system ( 1 ) according to claim 1 , wherein the magazine device ( 13 ) is configured to provide full receptacles ( 14 ) on a first side ( 40 ) of the beta flange ( 37 ) at a first distance ( 42 ) and to move the receptacles ( 14 ) after they have been positioned in the removal position ( 16 ) on the beta flange ( 37 ) to a second side ( 41 ) of the beta flange ( 37 ) which is opposite the first side ( 40 ), wherein the receptacles ( 14 ) are mounted on the second side ( 41 ) at a second distance ( 43 ) that is smaller than the first distance ( 42 ).
8 . The transfer system ( 1 ) according to claim 1 , wherein the beta flange ( 37 ) of the beta component ( 8 ) is arranged on a coupling side ( 34 ) of the beta component ( 8 ) and the beta component ( 8 ) has a closable loading opening ( 36 ) on a loading side ( 35 ) of the beta component ( 8 ).
9 . The transfer system ( 1 ) according to claim 1 , wherein a pull-out drawer-like insert ( 17 ) is provided in each receptacle ( 14 ) for receiving the objects ( 19 ) to be transferred, wherein the transfer system ( 1 ) is configured such that when the alpha component ( 7 ) and the beta component ( 8 ) are connected to one another and are open, the insert ( 17 ) of the receptacle ( 14 ), which is currently positioned in the removal position, can be moved from the receiving space ( 12 ), through the alpha flange ( 10 ) and into the isolation region ( 4 ).
10 . The transfer system ( 1 ) according to claim 1 , wherein the beta component ( 8 ) comprises rollers ( 32 ) by which the beta component ( 8 ) can be moved, wherein a position of the beta flange ( 37 ) relative to the rollers ( 32 ) can be vertically adjusted by a vertical adjustment device ( 33 ).
11 . The transfer system ( 1 ) according to claim 1 , wherein the magazine device ( 13 ) is configured as a paternoster system ( 46 ) so that the receptacles ( 14 ) are arranged a whole way around the paternoster system ( 46 ).
12 . A barrier system having a transfer system ( 1 ) according to claim 1 , wherein a centering device ( 21 ) is arranged in the barrier system.
13 . A production plant ( 3 ) comprising a barrier system according to claim 12 .
14 . The transfer system according to claim 1 , wherein the barrier system includes an isolator ( 2 ).
15 . The transfer system according to claim 1 , wherein the beta container ( 11 ) is dimensionally stable.
16 . The transfer system according to claim 9 , wherein the pull-out drawer-like insert ( 17 ) is replaceable.
17 . The transfer system according to claim 3 , wherein the beta component ( 8 ) comprises a drain ( 27 ) for removing sterilization medium from the receiving space ( 12 ).
18 . The transfer system according to claim 4 , wherein the collecting basin ( 28 ) forms a bottom surface of the receiving space ( 12 ).
19 . The transfer system according to claim 6 , wherein the axis of rotation ( 38 ) extends horizontally or vertically.
20 . The transfer system according to claim 8 , wherein the coupling side ( 34 ) is opposite the loading side ( 35 ).