MULTI-MODAL PHYSIOLOGICAL SENSOR
Apparatus and associated methods relate to a multimodal signal management system (MMSMS) that includes two or more electrodes, and a cerebrospinal fluid pressure (CSF) monitor enclosed within a housing implanted in the brain. In an illustrative example, the MMSMS, may, for example, include a conduit configured to provide fluid communication between the CSF-containing region in the brain and a remote location. Various embodiments may advantageously provide therapeutical CSF draining while monitoring electroencephalogram (EEG) and CSF pressure waveform information.
1 . A system comprising:
a housing, the housing configured to operably contact a dura while implanted through an aperture in a patient's skull, the housing providing an enclosure for a multimodal signal management engine (MMSME), the MMSME comprising:
at least one pressure sensor configurable to monitor a cerebrospinal fluid (CSF) pulsatile pressure in a CSF-filled region of a brain;
two or more electrodes configured to be in electrical contact with the dura and monitor an electroencephalogram (EEG) signal in the patient's brain;
a processor operatively coupled to the at least one pressure sensor and the two or more electrodes; and
a datastore containing instructions that, when operated by the processor, cause operations to be performed to collect a CSF pressure signal waveform and an EEG signal waveform over a predetermined period.
2 . The system of claim 1 , wherein the operations further comprise retrieving pressure sensor data representing the patient's CSF waveform signal.
3 . The system of claim 1 , wherein the operations further comprise retrieving electrode data representing the patient's EEG waveform signal.
4 . The system of claim 1 , wherein the operations further comprise retrieving a mode shift function from a parameter data store.
5 . The system of claim 4 , wherein the mode shift function is calculated based on stored pressure sensor data and stored electrode data.
6 . The system of claim 4 , wherein the mode shift function is retrieved based on a triggered predetermined alarm condition.
7 . The system of claim 1 , further comprising a ferrule having outer threads configured for fixedly engaging the ferrule in a burr hole of a skull, and inner threads configured to threadedly engage the housing, wherein the housing is axially positionable with respect to the dura by selective rotation of the housing while engaged in the ferrule.
8 . The system of claim 1 , wherein the two or more electrodes are communicably coupled to an electrode interface, wherein the electrode interface is positioned within the MMSME and electrically coupled to a capacitor, such that the electrode interface is configured to provide an electrical charge to the two or more electrodes via the capacitor.
9 . The system of claim 1 , wherein the housing further comprises an annular flex circuit, wherein the two or more two electrodes are operatively coupled to the annular flex circuit.
10 . The system of claim 1 , wherein the housing further comprises a catheter positioned at the base of the housing, wherein the catheter is configured to provide fluid communication from a CSF-filled region in the brain into the housing via an aperture in the dura.
11 . The system of claim 10 , wherein the catheter extends the fluid communication path distally to an external reservoir for drainage.
12 . The system of claim 10 , wherein the catheter provides a fluid communication path that extends through the housing and radially from the housing into a subcutaneous path to a location within the body for drainage.
13 . The system of claim 10 , further comprising a valve, the valve positioned radially outside from the MMSME housing, such that the valve is operably coupled to the catheter, wherein the valve is configured to control the rate of CSF drainage from the catheter.
14 . The system of claim 10 , wherein the at least one pressure sensor is positioned in the housing such that the at least one pressure sensor is operably coupled to the catheter, wherein the at least one pressure sensor is configured to monitor the pulsatile pressure of CSF within the catheter.
15 . The system of claim 1 , wherein the at least one pressure sensor is positioned in a subdural space such that the at least one pressure sensor is configured to provide fluid communication from a CSF-filled region in the brain into the housing via an aperture in the dura.