COMPOSITIONS AND METHODS FOR MODULATING HAIR GROWTH
The present disclosure relates to compounds that are capable of inhibiting the mitochondrial pyruvate carrier and promoting hair growth. The disclosure further relates to methods of promoting hair growth or treating conditions or disorders affecting hair growth, such as baldness or alopecia.
1 - 69 . (canceled)
70 . A method of promoting hair growth in a subject, comprising administering to the subject a compound having a structure
or a pharmaceutically acceptable salt thereof.
71 . The method of claim 70 , wherein the compound is
72 . The method of claim 70 , wherein the compound is a pharmaceutically acceptable salt of
73 . A method treating a condition or disorder affecting hair growth in a subject, comprising administering to the subject a compound having a structure
or a pharmaceutically acceptable salt thereof.
74 . The method of claim 73 , wherein the condition or disorder affecting hair growth is baldness.
75 . The method of claim 73 , wherein the condition or disorder affecting hair growth is alopecia.
76 . The method of claim 73 , wherein the compound is:
77 . The method of claim 76 , wherein the condition or disorder affecting hair growth is baldness.
78 . The method of claim 76 , wherein the condition or disorder is affecting hair growth alopecia.
79 . The method of claim 73 , wherein the compound is a pharmaceutically acceptable salt of
80 . The method of claim 79 , wherein the condition or disorder affecting hair growth is baldness.
81 . The method of claim 79 , wherein the condition or disorder affecting hair growth is alopecia.