DEVICE, SYSTEM AND METHOD FOR INTERMITTENT DISPLACEMENT OF BLOOD TO MITIGATE PERIPHERAL NERVE NEUROPATHY
Embodiments of the present invention are directed to devices, systems and methods adapted for implementing intermittent displacement of blood to mitigate peripheral nerve neuropathy such as that induced by chemotherapeutic agents (i.e., chemotherapy-induced neuropathy (CIN)) that are administered to a patient. Such devices, systems and methods advantageously provide for precise, uniform and controlled blood flow occluding (and optionally blood displacing) compression along irregular surfaces of an appendage of a patient. Such precise, uniform and controlled blood occluding compression is imparted upon the epidermal and dermis skin layers within the aforementioned areas of a patient's extremities to decrease the time that free nerve endings located in the epidermal and encapsulated nerve endings located in the dermis skin layers are exposed to nerve damaging chemotherapy chemicals, thereby substantially decreasing CIN caused by prolonged exposure to such chemicals.
1 . A controller operable for performing pressurization of a compression exertion device, the controller being operable for performing said pressurization includes:
causing a compression-inducing medium within the compression exertion device to exert a compressive pressure on a body part of a patient positioned within an interior space of the compression exertion device during a session of delivering a chemotherapeutic agent to the patient, wherein causing the compression-inducing medium to exert the compressive pressure includes monitoring information provided by a sensor operably engaged with the body part to characterize an amount of capillary blood flow within dermis tissue of the body part, wherein causing the compression-inducing medium within the compression exertion device to exert the compressive pressure includes causing the compression-inducing medium within the compression exertion device to maintaining said compressive pressure between atmospheric pressure and 50 mmHg, and wherein causing the compression-inducing medium to exert the compressive pressure includes causing the compression-inducing medium to exert the compressive pressure as a function of the amount of capillary blood flow.
2 . The controller of claim 1 wherein the compression-inducing medium comprises at least one of air, oxygen enriched air, and a water solution containing oxygen bubbles.
3 . The controller of claim 2 wherein causing the compression-inducing medium to exert the compressive pressure includes causing the compressive pressure to be exerted in a continuous manner over an entire duration of the session of said delivering.
4 . The controller of claim 1 wherein:
the compression-inducing medium comprises a tissue-treating medium; and
the tissue treating medium includes at least one of a perfluorocarbon oxygen carrier and a skin penetration enhancer.
5 . The controller of claim 1 wherein causing the compression-inducing medium to exert the compressive pressure includes causing the compressive pressure to be exerted in a continuous manner over an entire duration of the session of said delivering:
for a first duration of time during the session of said delivering, causing the compression-inducing medium through direct application of said compressive pressure on the body part to at least one of displace blood from the dermis tissue and at least partially restrict blood flow through capillary blood vessels within the dermis tissue; and
after the first duration of time, removing at least a portion of the compressive pressure for enabling increased blood flow through the capillary blood vessels.
6 . The controller of claim 5 wherein:
the compression-inducing medium comprises a water solution containing oxygen bubbles; and
said removing includes removing and replenishing at least a portion of the compression-inducing medium within the interior space of the compression exertion device.
7 . The controller of claim 1 wherein causing the compression-inducing medium to exert the compressive pressure includes causing the compressive pressure to be exerted in a continuous manner over an entire duration of the session of said delivering.
8 . The controller of claim 1 wherein:
causing the compression-inducing medium to exert the compressive pressure includes causing the compressive pressure to be adjusted to continuously provide partial capillary blood flow occlusion within the dermis tissue during an entire duration of the session of said delivering; and
the compression-inducing medium comprises a tissue-treating medium.
9 . The controller of claim 8 wherein the tissue treating medium includes at least one of one or more perfluorocarbon oxygen carriers, a water solution comprising nano oxygen bubbles and at least one skin penetration enhancer.
10 . The controller of claim 1 wherein:
the compression-inducing medium comprises a tissue-treating medium causing oxygen to be delivered into the dermis tissue; and
said exerting the compressive pressure on the body part includes removing and replenishing at least a portion of the compression-inducing medium within the interior space of the compression exertion device.
11 . The controller of claim 10 wherein causing the compression-inducing medium to exert the compressive pressure includes:
causing each of a plurality of instances of the compressive pressure being exerted on the body part for a designated duration of time followed by the compressive pressure being reduced; and
causing the compressive pressure to be exerted in a continuous manner over an entire duration of the session of said delivering.
12 . The controller of claim 1 wherein:
during a first duration of time during the session of said delivering, causing the compression-inducing medium to exert the compressive pressure includes causing the compression-inducing medium to exert a first compressive pressure that provides a first amount of reduction of blood flow within the capillary blood vessels of the dermis tissue;
after the first duration of time, causing the compression-inducing medium to exert the compressive pressure includes causing the compression-inducing medium to exert a second compressive pressure that is less than the first compressive pressure;
the second compressive pressure provides for greater flow of blood through capillary blood vessels within the dermis tissue than does the first compressive pressure; and
causing the compression-inducing medium to exert the compressive pressure includes causing the compressive pressure to be exerted in a continuous manner over an entire duration of the session of said delivering.
13 . The controller of claim 1 wherein said compressive pressure between atmospheric pressure- and 50 mmHg causes a reduction of said capillary blood flow of less than 50% relative to said capillary blood flow without said compressive pressure being exerted.
14 . The controller of claim 13 wherein causing the compression-inducing medium to exert the compressive pressure includes causing the compressive pressure to be exerted in a continuous manner over an entire duration of the session of said delivering:
for a first duration of time during the session of said delivering, causing the compression-inducing medium through direct application of said compressive pressure on the body part to at least one of displace blood from the dermis tissue and at least partially restrict blood flow through capillary blood vessels within the dermis tissue; and
after the first duration of time, removing at least a portion of the compressive pressure for enabling increased blood flow through the capillary blood vessels.
15 . The controller of claim 13 wherein causing the compression-inducing medium to exert the compressive pressure includes causing the compressive pressure to be exerted in a continuous manner over an entire duration of the session of said delivering.
16 . The controller of claim 1 wherein said compressive pressure between atmospheric pressure- and 50 mmHg causes a reduction of said capillary blood flow of more than 25% and less than 75% relative to said capillary blood flow without said compressive pressure being exerted.
17 . The controller of claim 16 wherein causing the compression-inducing medium to exert the compressive pressure includes causing the compressive pressure to be exerted in a continuous manner over an entire duration of the session of said delivering:
for a first duration of time during the session of said delivering, causing the compression-inducing medium through direct application of said compressive pressure on the body part to at least one of displace blood from the dermis tissue and at least partially restrict blood flow through capillary blood vessels within the dermis tissue; and
after the first duration of time, removing at least a portion of the compressive pressure for enabling increased blood flow through the capillary blood vessels.
18 . The controller of claim 16 wherein causing the compression-inducing medium to exert the compressive pressure includes causing the compressive pressure to be exerted in a continuous manner over an entire duration of the session of said delivering.
19 . The controller of claim 18 wherein causing the compression-inducing medium to exert the compressive pressure includes causing the compressive pressure to be exerted in a continuous manner over an entire duration of the session of said delivering:
for a first duration of time during the session of said delivering, causing the compression-inducing medium through direct application of said compressive pressure on the body part to at least one of displace blood from the dermis tissue and at least partially restrict blood flow through capillary blood vessels within the dermis tissue; and
after the first duration of time, removing at least a portion of the compressive pressure for enabling increased blood flow through the capillary blood vessels.
20 . The controller of claim 1 wherein said compressive pressure between atmospheric pressure- and 50 mmHg causes a reduction of said capillary blood flow of more than 10% and less than 90% relative to said capillary blood flow without said compressive pressure being exerted.