Granted Patent
B2
US 12,465,643 · App. 19/068,133 · Granted Nov 11, 2025
Ras inhibitors
Inventors:
Elena S. Koltun (Foster City, CA); James Cregg (Belmont, CA); Yang Liu (Foster City, CA); Adrian L. Gill (Atherton, CA)
Assignee:
Revolution Medicines, Inc.
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Abstract
The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.
Claims (3)
1 . A compound having the structure of:
or a pharmaceutically acceptable salt thereof, wherein at least one hydrogen atom of the compound is replaced by deuterium.
2 . A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient or carrier.
Assignments (19)
SECURITY INTEREST
Recorded Mar 26, 2026
From: REVOLUTION MEDICINES, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT
Reel/Frame 074200/0960 →
SECURITY INTEREST
Recorded Mar 26, 2026
From: REVOLUTION MEDICINES, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT
Reel/Frame 074200/0818 →
SECURITY INTEREST
Recorded Mar 26, 2026
From: REVOLUTION MEDICINES, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT
Reel/Frame 074200/0837 →
SECURITY INTEREST
Recorded Mar 26, 2026
From: REVOLUTION MEDICINES, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT
Reel/Frame 074200/0870 →
SECURITY INTEREST
Recorded Mar 26, 2026
From: REVOLUTION MEDICINES, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT
Reel/Frame 074200/0905 →
SECURITY INTEREST
Recorded Mar 26, 2026
From: REVOLUTION MEDICINES, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT
Reel/Frame 074200/0941 →
SECURITY INTEREST
Recorded Mar 26, 2026
From: REVOLUTION MEDICINES, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT
Reel/Frame 074196/0341 →
SECURITY INTEREST
Recorded Mar 26, 2026
From: REVOLUTION MEDICINES, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT
Reel/Frame 074197/0721 →
SECURITY INTEREST
Recorded Mar 26, 2026
From: REVOLUTION MEDICINES, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT
Reel/Frame 074199/0834 →
SECURITY INTEREST
Recorded Mar 26, 2026
From: REVOLUTION MEDICINES, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT
Reel/Frame 074200/0048 →
SECURITY INTEREST
Recorded Mar 26, 2026
From: REVOLUTION MEDICINES, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT
Reel/Frame 074200/0127 →
SECURITY INTEREST
Recorded Mar 26, 2026
From: REVOLUTION MEDICINES, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT
Reel/Frame 074200/0155 →
SECURITY INTEREST
Recorded Mar 26, 2026
From: REVOLUTION MEDICINES, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT
Reel/Frame 074200/0231 →
SECURITY INTEREST
Recorded Mar 26, 2026
From: REVOLUTION MEDICINES, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT
Reel/Frame 074200/0267 →
SECURITY INTEREST
Recorded Mar 24, 2026
From: REVOLUTION MEDICINES, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT
Reel/Frame 074172/0328 →
SECURITY INTEREST
Recorded Mar 24, 2026
From: REVOLUTION MEDICINES, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT
Reel/Frame 074172/0698 →
SECURITY INTEREST
Recorded Mar 24, 2026
From: REVOLUTION MEDICINES, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT
Reel/Frame 074172/0760 →
SECURITY INTEREST
Recorded Jun 25, 2025
From: REVOLUTION MEDICINES, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT
Reel/Frame 071721/0025 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 13, 2025
From: KOLTUN, ELENA S.; CREGG, JAMES; LIU, YANG; GILL, ADRIAN L.
To: REVOLUTION MEDICINES, INC.
Reel/Frame 071410/0138 →