ENCAPSULATION OF GASTRIC RESIDENCE SYSTEMS
Compactable gastric residence systems comprising therapeutic agent formulations for sustained gastric release of therapeutic agents are disclosed, as well as methods and systems for encapsulating such gastric residence systems. The methods and systems for encapsulating the gastric residence systems can be automated from receiving a bulk of gastric residence systems, orienting, placing, compacting, securing, and encapsulating the gastric residence systems.
1 . A gastric residence system comprising:
a plurality of elongate members connected at a proximal end of each elongate member, the plurality of elongate members extending radially from the proximal ends; and
a flexible runner circumferentially connecting each elongate member of the plurality of elongate members.
2 . The gastric residence system of claim 1 , comprising a linking member, wherein the proximal end of each elongate member is attached to the linking member.
3 . The gastric residence system of claim 2 , wherein the linking member comprises an elastomer.
4 . The gastric residence system of claim 1 , wherein the plurality of elongate members comprises at least three elongate members.
5 . The gastric residence system of claim 1 , wherein each elongate member comprises one or more carrier polymer-agent components.
6 . The gastric residence system of claim 5 , wherein each carrier polymer-agent component comprises a therapeutic agent.
7 . The gastric residence system of claim 1 , wherein each elongate member comprises one or more coupling polymer components.
8 . The gastric residence system of claim 7 , wherein the one or more coupling polymer components comprise a polymer which degrades in a time-dependent manner.
9 . The gastric residence system of claim 7 , wherein the one or more coupling polymer components comprise an enteric polymer.
10 . The gastric residence system of claim 1 , wherein each elongate member of the plurality of elongate members comprises the proximal end, a distal end, and a middle portion therebetween.
11 . The gastric residence system of claim 10 , wherein the flexible runner is connected to the middle portion of each elongate member.
12 . The gastric residence system of claim 1 , wherein a portion of the flexible runner is embedded within each elongate member of the plurality of elongate members.
13 . The gastric residence system of claim 1 , wherein the flexible runner is formed from injection molding.
14 . The gastric residence system of claim 1 , wherein the flexible runner is configured to pull the plurality of elongate members into a compacted configuration when an upward force is applied to the flexible runner.
15 . The gastric residence system of claim 14 , wherein the upward force is applied by an anchor system.
16 . The gastric residence system of claim 15 , wherein the anchor system is configured to grip the flexible runner between the plurality of elongate members.
17 . The gastric residence system of claim 1 , wherein the gastric residence system is configured to be inserted into a container when the gastric residence system is in a compacted configuration.
18 . The gastric residence system of claim 17 , wherein the container is a capsule or a half-capsule.
19 . The gastric residence system of claim 1 , wherein the gastric residence system is configured to be compacted during administration and is configured to assume an open configuration when in a patient's stomach.
20 . The gastric residence system of claim 19 , wherein the gastric residence system has a multi-armed star shape in the open configuration.