DURABLE SURFACE COATINGS
Described herein are durable coatings, i.e. for medical devices, and methods of forming the coatings.
1 . A coating comprising, a base coat including halopropylsilanyl, haloheptylsilanyl, haloundecylsilanyl, or a combination thereof, wherein halo is bromo, chloro, or iodo.
2 . The coating of claim 1 , wherein the base coat is covalently linked to a surface of a medical device.
3 . The coating of claim 2 , further comprising a top coat that includes a polymeric moiety having an amine moiety.
4 . The coating of claim 3 , wherein the polymeric moiety is a poly(MEA-co-APMA) polymer, an amine functionalized poly(ethylene glycol) polymer, an amine functionalized poly(vinyl alcohol), an amine functionalized hyaluronic acid, or a combination thereof.
5 . The coating of claim 4 , wherein the base coat and top coat are covalently linked such that an aminoalkylsilanyl moiety is present.
6 . The coating of claim 5 , wherein the coating is about 100 nanometers thick or less.
7 . The coating of claim 5 , wherein the medical device coating is about 10 nanometers thick or less.
8 . The coating of claim 5 , wherein the medical device coating is about 1 nanometer thick.
9 . The coating of claim 5 , wherein the amine moiety is a secondary amine.
10 . The coating of claim 5 , wherein the medical device is metallic or plastic.
11 . The coating of claim 5 , wherein the medical device is a catheter or a guidewire.
12 . The coating of claim 11 , wherein the medical device is a catheter.
13 . The coating of claim 11 , wherein the medical device is a guidewire.
14 . The coating of claim 5 , wherein the medical device is an implantable medical device.
15 . The coating of claim 14 , wherein the implantable medical device is a stent.
16 . The coating of claim 5 , further comprising contacting the surface of the medical device with a hydroxylating agent prior to forming the base coat.
17 . The coating of claim 5 , wherein halo is bromo, and the polymeric moiety having an amine moiety is a copolymer of 2-methoxyethyl acrylate and N-(3-aminopropyl)methacrylamide.
18 . The coating of claim 5 , wherein the base coat includes 3-bromopropyltrimethoxysilane, 7-bromoheptyltrimethoxysilane, 11-bromoundecyltrimethoxysilane, or a combination thereof.
19 . The coating of claim 5 , wherein the base coat includes 3-bromopropyltrimethoxysilane, and the polymeric moiety having an amine moiety is a copolymer of 2-methoxyethyl acrylate and N-(3-aminopropyl)methacrylamide.
20 . The coating of claim 5 , comprising the structure