Olfactory delivery scaffold compounds
Exemplary olfactory delivery scaffolds may include 1) an olfactory targeting component, stimulant, or odorant that is recognized by the olfactory nerves via, for example, a smell response, 2) a molecule with biological activity, a therapeutic component, and/or drug (sometimes collectively referred to herein as a “therapeutic component”), and 3) a linker component that links the olfactory targeting component and therapeutic component together. The olfactory delivery scaffolds may be used to deliver a molecule with biological activity and/or a therapeutic component to a subject's neurological system through the olfactory pathway and pharmaceutical compositions useful in the treatment of neurological and/or neurodegenerative diseases.
1 . A compound of Formula (D):
wherein,
R 1 R 2 N is selected from the group consisting of:
R 4 is H or C 1 -C 8 alkyl; and
R 3 is selected from the group consisting of:
2 . The compound of claim 1 , wherein the compound is
3 . The compound of claim 1 , wherein R 1 R 2 N is
4 . The compound of claim 1 , wherein R 1 R 2 N is
5 . The compound of claim 1 , wherein R 3 is
6 . The compound of claim 1 , wherein R 3 is
7 . The compound of claim 1 , wherein R 3 is
8 . The compound of claim 1 , wherein R 3 is
9 . The compound of claim 1 , wherein R 3 is
10 . A pharmaceutical composition for intranasal administration comprising the compound of claim 1 and a pharmaceutically acceptable carrier.