IP Library › Granted Patent US 12,427,184
Granted Patent B2
US 12,427,184 · App. 19/186,092 · Granted Sep 30, 2025

Treatment of immunosuppressed subjects

Inventor: Patrick Soon-Shiong (Culver City, CA)
Assignee: NantCell, Inc.
A61K38/2086A61K31/427A61K31/4418A61K31/496A61K31/513A61K31/52A61K31/536A61K31/635A61K31/675A61K31/7068A61K31/7072A61K38/1793A61K47/642A61K47/6425A61P31/18
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Quick Facts
Patent No.
US 12,427,184
App. No.
19/186,092
Granted
Sep 30, 2025
Kind
B2
Abstract

An IL-15 super agonist (IL-15N72D:IL-15RαSU/IgG1Fc; N-803) increases circulating NK cells, effector memory and effector memory RA cells in post-allogeneic hematopoietic stem cell transplant patients (HCT). Methods of treatment include administration of N-803 to subjects in need of such treatment.

Claims (13)

1. A method of treating a JC polyomavirus virus (JCV) infection in a subject, the method comprising administering to the subject a composition comprising a therapeutically effective amount of an IL-15:IL-15Rα complex, wherein the IL-15:IL-15Rα complex increases the number of circulating immune effector cells and/or activates immune effector cells.

2. The method of claim 1 , wherein the IL-15:IL-15Rα complex is an IL-15N72D:IL-15RαSu/Fc complex (N-803) comprising a dimeric IL-15RαSu/Fc and two IL-15N72D molecules.

3. The method of claim 1 , wherein the immune effector cells comprise natural killer cells (NK), effector memory (T EM ) T cells (CD45RA − /CCR7 − ), effector memory RA (T EMRA ) T cells (CD45RA + /CCR7 − ), cytolytic T cells (CTLs), T helper cells (T H ) or combinations thereof.

4. The method of claim 1 , wherein activated immune effector cells comprise one or more markers comprising CD38, perforin, granzyme B, Ki-67, HLA-DR or combinations thereof.

5. The method of claim 1 , optionally comprising administering one or more chemotherapeutic agents, compounds, cytokine antagonist, cytokine receptor antagonist, cytokines, adoptive cell therapy, anti-viral agents, checkpoint inhibitors, adjuvants or combinations thereof.

6. The method of claim 1 , wherein the subject is suffering from a human immunodeficiency virus (HIV) infection.

7. The method of claim 6 , wherein the HIV infection is a latent infection.

8. The method of claim 6 , wherein the IL-15:IL-15Rα complex decreases JCV virus count in the subject.

9. The method of claim 6 , wherein the IL-15:IL-15Rα complex, decreases JCV DNA copy number.

10. The method of claim 1 , wherein the therapeutically effective amount of the IL-15:IL-15Rα complex is from about 1 mcg/kg to about 6.0 mcg/kg.

11. The method of claim 10 , wherein the IL-15:IL-15Rα complex is administered subcutaneously or intravenously.

12. The method of claim 1 , wherein the IL-15:IL-15Rα complex decreases JCV virus count in the subject.

13. The method of claim 1 , wherein the IL-15:IL-15Rα complex, decreases JCV DNA copy number.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 24, 2025
From: SOON-SHIONG, PATRICK
To: NANTCELL, INC.
Reel/Frame 070937/0175 →
Continuity (5)
Continuation 18808392 · Aug 19, 2024
Division 18326293 · May 31, 2023
Continuation 17284406
Provisional Application 62744601 · Oct 11, 2018
Related Publication 20250249073A1 · Aug 7, 2025
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