IP Library › Granted Patent US 12,702,487
Granted Patent B2
US 12,702,487 · App. 19/193,592 · Granted Aug 11, 2026

System and method for automated volumetric spinal assessment

Inventors: Isador Lieberman (Plano, TX); Samuel Shannon (Karmei Yosef, IL); Jacov Blank (Ramat Hasharon, IL); Damon Eugene Mar (Kansas City, KS)
Assignee: AGADA Medical LTD.
A61B34/10A61B5/0033A61B5/4566G16H10/20G16H20/40A61B2034/104
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,702,487
App. No.
19/193,592
Filed
Apr 29, 2025
Granted
Aug 11, 2026
Kind
B2
Examiner
PAN, YONGJIA
Art Unit
2118
USPC
700/48
Abstract

Systems, methods, and computer-readable storage media for measuring spinal canal volume in vertebrates, and more specifically to using Artificial Intelligence (AI) to predict how surgical options will affect spinal canal volume. A system configured as disclosed herein can receive two or more pre-operation medical images capturing at least one functional spinal unit, then calculate an initial spinal canal regional volume using the pre-operation medical images for at least a portion of the at least one functional spinal unit. The system can then calculate, using a neural network, a predicted spinal canal regional volume for at least a portion of the at least one functional spinal unit undergoing various spine surgery options separately, resulting in predicted spinal canal regional volumes corresponding to the plurality of spine surgery options. The system or a surgeon can then select, using that data, one or more of the spine surgery options.

Claims (59)

1 . A method comprising:

receiving, at a computer system, at least two pre-operation medical images, the at least two pre-operation medical images each capturing at least one functional spinal unit;

generating regional volumetric stenosis measurements of the at least one functional spinal unit;

calculating, via at least one processor of the computer system using the at least two pre-operation medical images and the regional volumetric stenosis measurements, an initial spinal canal regional volume for at least a portion of the at least one functional spinal unit;

identifying a plurality of spine surgery options;

calculating, via the at least one processor executing a neural network wherein the regional volumetric stenosis measurements are inputs to the neural network, a predicted spinal canal regional volume for the at least a portion of the at least one functional spinal unit undergoing each of the plurality of spine surgery options separately, resulting in a plurality of predicted spinal canal regional volumes corresponding to the plurality of spine surgery options; and

selecting, based at least in part on the plurality of predicted spinal canal regional volumes, a selected spine surgery option from the plurality of spine surgery options,

such that the selected spine surgery option is executed on the at least one functional spinal unit.

2 . The method of claim 1 , wherein the at least two pre-operation medical images are part of a pre-operation medical study.

3 . The method of claim 1 , further comprising:

receiving, at the computer system after execution of the selected spine surgery option, at least two post-operation medical images, the at least two post-operation medical images capturing the at least one functional spinal unit;

calculating, via the at least one processor of the computer system using the at least two post-operation medical images, a post-operation spinal canal regional volume;

comparing, via the at least one processor, the post-operation spinal canal regional volume to the initial spinal canal regional volume, resulting in a comparison; and

updating the neural network based on the comparison.

4 . The method of claim 3 , wherein the comparing further comprises comparing the post-operation spinal canal regional volume to at least one predicted spinal canal regional volume of the plurality of predicted spinal canal regional volumes, wherein one predicted spinal canal regional volume within the at least one predicted spinal canal regional volume is based on the selected spine surgery option.

5 . The method of claim 1 , wherein the neural network further predicts, for each of the plurality of spine surgery options, a predicted stenosis resolution, resulting in a plurality of predicted stenosis resolutions; and

wherein the selected spine surgery option is selected, at least in part, based on which of the plurality of spine surgery options is most likely to reduce stenosis symptoms.

6 . The method of claim 1 , wherein each pre-operation medical image in the at least two pre-operation medical images is at least one of a CT, a MRI, an X-ray and an Ultrasound image.

7 . The method of claim 1 , wherein the regional volumetric stenosis measurements comprise:

canal regions comprising: central, lateral recess, and foraminal; and

level regions comprising: disc level, vertebral body level, and pedicle level.

8 . A system comprising:

at least one processor; and

a non-transitory computer-readable storage medium having instructions stored which, when executed by the at least one processor, cause the at least one processor to perform operations comprising:

receiving at least two pre-operation medical images, the at least two pre-operation medical images each capturing at least one functional spinal unit;

generating regional volumetric stenosis measurements of the at least one functional spinal unit;

calculating, using the at least two pre-operation medical images and the regional volumetric stenosis measurements, an initial spinal canal regional volume for at least a portion of the at least one functional spinal unit;

identifying a plurality of spine surgery options;

calculating, by executing a neural network wherein the regional volumetric stenosis measurements are inputs to the neural network, a predicted spinal canal regional volume for the at least a portion of the at least one functional spinal unit undergoing each of the plurality of spine surgery options separately, resulting in a plurality of predicted spinal canal regional volumes corresponding to the plurality of spine surgery options; and

selecting, based at least in part on the plurality of predicted spinal canal regional volumes, a selected spine surgery option from the plurality of spine surgery options,

such that the selected spine surgery option is executed on the at least one functional spinal unit.

9 . The system of claim 8 , wherein the at least two pre-operation medical images are part of a pre-operation medical study.

10 . The system of claim 8 , the non-transitory computer-readable storage medium having additional instructions stored which, when executed by the at least one processor, cause the at least one processor to perform operations comprising:

receiving, after execution of the selected spine surgery option, at least two post-operation medical images, the at least two post-operation medical images capturing the at least one functional spinal unit;

calculating, using the at least two post-operation medical images, a post-operation spinal canal regional volume;

comparing the post-operation spinal canal regional volume to the initial spinal canal regional volume, resulting in a comparison; and

updating the neural network based on the comparison.

11 . The system of claim 10 , wherein the comparing further comprises comparing the post-operation spinal canal regional volume to at least one predicted spinal canal regional volume of the plurality of predicted spinal canal regional volumes, wherein one predicted spinal canal regional volume within the at least one predicted spinal canal regional volume is based on the selected spine surgery option.

12 . The system of claim 8 , wherein the neural network further predicts, for each of the plurality of spine surgery options, a predicted stenosis resolution, resulting in a plurality of predicted stenosis resolutions; and

wherein the selected spine surgery option is selected, at least in part, based on which of the plurality of spine surgery options is most likely to reduce stenosis symptoms.

13 . The system of claim 8 , wherein each pre-operation medical image in the at least two pre-operation medical images is at least one of a CT, a MRI, an X-ray and an Ultrasound image.

14 . The system of claim 8 , wherein the regional volumetric stenosis measurements comprise:

canal regions comprising: central, lateral recess, and foraminal; and

level regions comprising: disc level, vertebral body level, and pedicle level.

15 . A non-transitory computer-readable storage medium having instructions stored which, when executed by at least one processor, cause the at least one processor to perform operations comprising:

receiving at least two pre-operation medical images, the at least two pre-operation medical images each capturing at least one functional spinal unit;

generating regional volumetric stenosis measurements of the at least one functional spinal unit;

calculating, using the at least two pre-operation medical images and the regional volumetric stenosis measurements, an initial spinal canal regional volume for at least a portion of the at least one functional spinal unit;

identifying a plurality of spine surgery options;

calculating, by executing a neural network wherein the regional volumetric stenosis measurements are inputs to the neural network, a predicted spinal canal regional volume for the at least a portion of the at least one functional spinal unit undergoing each of the plurality of spine surgery options separately, resulting in a plurality of predicted spinal canal regional volumes corresponding to the plurality of spine surgery options; and

selecting, based at least in part on the plurality of predicted spinal canal regional volumes, a selected spine surgery option from the plurality of spine surgery options,

such that the selected spine surgery option is executed on the at least one functional spinal unit.

16 . The non-transitory computer-readable storage medium of claim 15 , wherein the at least two pre-operation medical images are part of a pre-operation medical study.

17 . The non-transitory computer-readable storage medium of claim 15 , having additional instructions stored which, when executed by the at least one processor, cause the at least one processor to perform operations comprising:

receiving, after execution of the selected spine surgery option, at least two post-operation medical images, the at least two post-operation medical images capturing the at least one functional spinal unit;

calculating, using the at least two post-operation medical images, a post-operation spinal canal regional volume;

comparing the post-operation spinal canal regional volume to the initial spinal canal regional volume, resulting in a comparison; and

updating the neural network based on the comparison.

18 . The non-transitory computer-readable storage medium of claim 17 , wherein the comparing further comprises comparing the post-operation spinal canal regional volume to at least one predicted spinal canal regional volume of the plurality of predicted spinal canal regional volumes, wherein one predicted spinal canal regional volume within the at least one predicted spinal canal regional volume is based on the selected spine surgery option.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 23, 2026
From: LIEBERMAN, ISADOR; SHANNON, SAMUEL; BLANK, JACOV; MAR, DAMON EUGENE
To: AGADA MEDICAL LTD.
Reel/Frame 075376/0454 →
Continuity (2)
Provisional Application 63642451 · May 3, 2024
Related Publication 20250339205A1 · Nov 6, 2025
References Cited (41)
US 11803754B2 · Pasha · 2023 [cited by examiner]
US 12207883B2 · McKinnon et al. · 2025 [cited by applicant]
US 20140187908A1 · Ellermann et al. · 2014 [cited by applicant]
US 20190388099A1 · Zuhars et al. · 2019 [cited by applicant]
US 20200038109A1 · Steinberg · 2020 [cited by examiner]
US 20210059822A1 · Casey et al. · 2021 [cited by applicant]
US 20210161682A1 · O'Neil et al. · 2021 [cited by applicant]
US 20210378752A1 · Paul · 2021 [cited by examiner]
US 20220000556A1 · Casey · 2022 [cited by examiner]
US 20220013211A1 · Steinberg et al. · 2022 [cited by applicant]
US 20220125602A1 · Zucker · 2022 [cited by examiner]
US 20220157459A1 · Siewerdsen · 2022 [cited by examiner]
US 20220249168A1 · Besier · 2022 [cited by examiner]
US 20220392642A1 · Dasi · 2022 [cited by examiner]
US 20230085604A1 · Metcalfe et al. · 2023 [cited by applicant]
US 20230134461A1 · Casey · 2023 [cited by examiner]
US 20230138162A1 · Winston · 2023 [cited by examiner]
US 20230240749A1 · Lev-Tov · 2023 [cited by applicant]
US 20230255696A1 · Roh et al. · 2023 [cited by applicant]
US 20230360768A1 · Shannon · 2023 [cited by examiner]
US 20240065767A1 · Cordonnier · 2024 [cited by examiner]
US 20240065800A1 · Frey et al. · 2024 [cited by applicant]
US 20240115324A1 · Mosnier · 2024 [cited by examiner]
US 20240156532A1 · Weiman · 2024 [cited by examiner]
US 20240374314A1 · Frey et al. · 2024 [cited by applicant]
CN 113679404A · 2021 [cited by applicant]
CN 115736965A · 2023 [cited by applicant]
CN 118864498A · 2024 [cited by applicant]
RU 2396896 · 2010 [cited by applicant]
WO 2016171570A1 · 2016 [cited by applicant]
WO 2023096516A1 · 2023 [cited by applicant]
Bayard et al., Predicting Spinal Surgery Candidacy From Imaging Data Using Machine Learning, Jul. 2021, 6 page (Year: 2021). [cited by examiner]
International Search Report and Written Opinion mailed Jun. 30, 2025, directed to International Patent Application No. PCT/IB2025/054463; 13 pages. [cited by applicant]
Liebl, H. et al., (2021). “A computed tomography vertebral segmentation dataset with anatomical variations and multi-vendor scanner data,” Scientific Data 8:284, retrieved at <https://doi.org/10.1038/s41597-021-01060-0>… [cited by applicant]
Ritter, D. et al., (Jan. 2024). “Preoperative 3D Computed Tomography Bone Density Measures Provide Objective Bone Quality Classifications for Stemless Anatomic Total Shoulder Arthroplasty,” Journal of Should and Elbow S… [cited by applicant]
Deshpande, N. et al., (Jan. 2023). “Alternatives to DEXA for the Assessment of Bone Density; A Systematic Review of the Literature and Future Recommendations ,” Journal of Neurosurgery: vo., 38; No. 4, pp. 436-445, retr… [cited by applicant]
Parr et al., (Dec. 2019). “3D Printed Anatomical (bio)Models in Spine Surgery; Clinical Benefits and Value to Health Care Providers,” Journal of Spine Surgery; 5(4); pp. 549-560. [cited by applicant]
Martín-Noguerol, T. et al., (Jan. 2023). “The Role of Artificial Intelligence in the Assessment of the Spine and Spinal Cord,” European Journal of Radiology; retrieved at <https://www.ejradiology.com/article/S0720-048X(… [cited by applicant]
Shi, L. et al., (Apr. 2025). “The Application of Artificial Intelligence in Spine Surgery: A Scoping Review,” Journal of the AAOS Global Research & Reviews: vol. 9; No. 4; 13 pages. [cited by applicant]
Khan, M. et al., (Jan. 2025). “Artificial Intelligence and Its Use in Spinal Surgery and Preparation of Predictive Models: A Systematic Review,” Annals of Medicine & Surgery; pp. 171-176. [cited by applicant]
International Search Report and Written Opinion mailed Dec. 4, 2025, directed to International Patent Application No. PCT/US2025/045338; 14 pages. [cited by applicant]