IP Library › Granted Patent US 12,570,995
Granted Patent B2
US 12,570,995 · App. 19/201,636 · Granted Mar 10, 2026

Insecticidal proteins compositions and methods of use

Inventors: Laurent Décousset (Champaign, IL); James Winsor (Champaign, IL); Yuanyuan Hu (Champaign, IL); Madison Havel (Champaign, IL); Christophe Sallaud (Champaign, IL); Mickael Bosio (Champaign, IL)
Assignee: GENECTIVE SA
C12N15/8286A01N37/46A01P7/04C07K14/195
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Quick Facts
Patent No.
US 12,570,995
App. No.
19/201,636
Granted
Mar 10, 2026
Kind
B2
Abstract

Disclosed herein are transformed plants, plant tissues, plant parts, plant cells, and plant seeds comprising a recombinant nucleic acid molecule encoding a polypeptide having pesticidal activity. Also disclosed herein are methods of protecting or treating a plant from infection by a plant pathogen or pest by transforming plants, plant tissues, plant parts, plant cells, and plant seeds with a recombinant nucleic acid molecule encoding a polypeptide having pesticidal activity.

Claims (5)

1 . A transformed plant, seed, or plant part comprising a recombinant nucleic acid molecule encoding a polypeptide of any one of SEQ ID NOs: 1, 12, 19, 20, 24, 30, 42, 45, 46, 50, 55, or 57 stably incorporated into a genome of the transformed plant, seed, or plant part, wherein the transformed plant, seed, or plant part stably expresses the polypeptide, wherein the polypeptide has pesticidal activity against a plant pathogen or pest comprising corn rootworm ( Diabrotica virgifera ), western corn rootworm ( Diabrotica virgifera virgifera ), northern corn rootworm ( Diabrotica barberi ), southern corn rootworm ( Diabrotica undecimpunctata howardi ), or combinations thereof, and wherein the recombinant nucleic acid molecule encoding the polypeptide is operably linked to one or more heterologous promoter sequences.

2 . The transformed plant, seed, or plant part of claim 1 , wherein the transformed plant, seed, or plant part is selected from the group consisting of rice, barley, sorghum, soybean, cotton, maize, rapeseed, sugar cane, tobacco, sunflower, and wheat.

3 . A recombinant nucleic acid molecule comprising a polynucleotide sequence encoding a polypeptide of SEQ ID NOs: 1, 12, 19, 20, 24, 30, 42, 45, 46, 50, 55, or 57, wherein the polypeptide has pesticidal activity against a plant pathogen or pest comprising corn rootworm ( Diabrotica virgifera ), western corn rootworm ( Diabrotica virgifera virgifera ), northern corn rootworm ( Diabrotica barberi ), southern corn rootworm ( Diabrotica undecimpunctata howardi ), or combinations thereof, and wherein the polynucleotide sequence encoding the polypeptide is operably linked to one or more heterologous promoter sequences.

4 . A vector comprising a recombinant nucleic acid molecule comprising a polynucleotide sequence encoding a polypeptide of any one of SEQ ID NOs: 1, 12, 19, 20, 24, 30, 42, 45, 46, 50, 55, or 57, wherein the polypeptide has pesticidal activity against a plant pathogen or pest comprising corn rootworm ( Diabrotica virgifera ), western corn rootworm ( Diabrotica virgifera virgifera ), northern corn rootworm ( Diabrotica barberi ), southern corn rootworm ( Diabrotica undecimpunctata howardi ), or combinations thereof, and wherein the polynucleotide sequence encoding the polypeptide is operably linked to one or more heterologous promoter sequences.

5 . A transformed host cell comprising a recombinant nucleic acid molecule comprising a polynucleotide sequence encoding a polypeptide of any one of SEQ ID NOs: 1, 12, 19, 20, 24, 30, 42, 45, 46, 50, 55, or 57, wherein the polypeptide has pesticidal activity against a plant pathogen or pest comprising corn rootworm ( Diabrotica virgifera ), western corn rootworm ( Diabrotica virgifera virgifera ), northern corn rootworm ( Diabrotica barberi ), southern corn rootworm ( Diabrotica undecimpunctata howardi ), or combinations thereof, and wherein the polynucleotide sequence encoding the polypeptide is operably linked to one or more heterologous promoter sequences.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 8, 2026
From: DÉCOUSSET, LAURENT; WINSOR, JAMES; HU, YUANYUAN; HAVEL, MADISON; SALLAUD, CHRISTOPHE; BOSIO, MICKAEL
To: GENECTIVE SA
Reel/Frame 073412/0263 →
Continuity (2)
Provisional Application 63644183 · May 8, 2024
Related Publication 20250346916A1 · Nov 13, 2025
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