DIMETHOXYPHENYLALKYLAMINE ACTIVATORS OF SEROTONIN RECEPTORS
Provided herein are compounds of Formula (I), or pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and n are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) or pharmaceutically acceptable salt thereof, and methods of using a compound of Formula (I) or pharmaceutically acceptable salt thereof, e.g., in the treatment of a mental health disease or disorder.
1 . A compound of formula (I-A):
or a pharmaceutically acceptable salt thereof, wherein:
R 1 is independently at each position -hydrogen, —C 1 -C 6 alkyl, or —C 1 -C 6 haloalkyl;
R 2 and R 3 are each independently -hydrogen, —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, -halogen, -cyano, —OR 1 or —SR 1 , wherein at least one of R 2 and R 3 is -hydrogen;
R 4 , R 5 , and R 6 are each independently -hydrogen, —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, -halogen, -cyano, —OR 1 , —SR 1 , —O(C═O)(R 12 ), or —NH(C═O)(R 12 ), wherein R 12 is C 1 -C 6 alkyl; and
n is 0, 1, 2, or 3.
2 . The compound of claim 1 , wherein R 1 is —C 1 -C 6 alkyl.
3 . The compound of claim 1 , wherein R 1 is -methyl, -ethyl, -propyl, or -isopropyl.
4 . The compound of claim 1 , wherein R 1 is -methyl.
5 . The compound of claim 1 , wherein R 2 is -hydrogen, -halo, or —C 1 -C 6 alkyl.
6 . The compound of claim 1 , wherein R 3 is -hydrogen, -halo, or —C 1 -C 6 alkyl.
7 . The compound of claim 1 , wherein R 2 is -halogen and R 3 is -hydrogen.
8 . The compound of claim 1 , wherein R 2 is -hydrogen and R 3 is -halogen.
9 . The compound of claim 1 , wherein R 2 and R 3 are each -hydrogen.
10 . The compound of claim 1 , wherein R 4 , R 5 and R 6 are each independently -hydrogen, —C 1 -C 6 alkyl, or -halogen.
11 . The compound of claim 1 , wherein R 4 , R 5 and R 6 are each independently -hydrogen, -methyl, or -halogen.
12 . The compound of claim 1 , wherein n is 1.
13 . The compound of claim 1 , wherein n is 2.
14 . The compound of claim 1 , wherein the compound is:
a pharmaceutically acceptable salt thereof.
15 . The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
16 . The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.