MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USES THEREOF
The present invention provides compounds, compositions thereof, and methods of using the same.
1 - 31 . (canceled)
32 . A process for preparing a compound selected from:
comprising hydrogenating a compound selected from:
33 . The process of claim 32 for preparing the compound selected from:
the process comprising subjecting a compound selected from:
to chiral chromatography.
34 . The process of claim 33 , wherein the chiral chromatography is reverse phase chromatography using a chiral column.
35 . The process of claim 33 for preparing the compound selected from:
the process comprising adding a carbobenzyloxy (Cbz) group to a compound selected from:
36 . The process of claim 35 , wherein the adding of a Cbz group comprises benzyl N-succinimidyl carbonate (Cbz-OSu) and sodium bicarbonate in aqueous acetone.
37 . The process of claim 35 for preparing the compound selected from:
the process comprising hydrogenating a compound selected from:
38 . The process of claim 37 , wherein the hydrogenation comprises palladium on carbon and ammonium formate in methanol.
39 . The process of claim 37 for preparing the compound selected from:
the process comprising treating a compound selected from:
with an acid.
40 . The process of claim 39 , wherein the acid is hydrogen chloride in acetic acid.
41 . The process of claim 39 for preparing the compound selected from:
the process comprising treating a compound selected from:
with benzylamine, acetic acid, and trimethylsilyl cyanide in diethyl ether.
42 . The process of claim 41 for preparing the compound selected from:
the process comprising treating a compound selected from:
with lithium aluminum hydride in tetrahydrofuran.
43 . The process of claim 42 for preparing the compound selected from:
the process comprising treating a compound selected from:
with (1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate (HATU), triethylamine or diisopropylethylamine, and N,O-dimethylhydroxylamine hydrochloride in N,N-dimethylformamide.
44 . The process of claim 43 for preparing the compound selected from:
the process comprising treating a compound selected from:
with lithium hydroxide in aqueous dimethylsulfoxide.
45 . The process of claim 44 for preparing the compound selected from:
the process comprising treating a compound selected from:
with methylmagnesium iodide, ethylmagnesium bromide, n-propylmagnesium bromide isopropylmagnesium bromide, or n-butylmagnesium bromide, and copper iodide in dichloromethane, tetrahydrofuran, or dichloromethane and tetrahydrofuran.