METHOD AND DEVICE FOR FELLOW-EYE CORNEAL TOPOGRAPHY
A device and method for early detection of eye disease including a corneal topography device configured to measure the elevation of a patient's anterior and posterior corneas sequentially or simultaneously; organize the elevation data for each cornea into a two-dimensional matrix where the center of the cornea is in the center of the data frame, rotate the data for a first eye 180 degrees around the Y axis relative to a second eye, subtract data on each corresponding corneal point, and generate an elevation difference matrix showing the degree of symmetry or asymmetry between the patient's left and right eye corneal topography. A quantitative corneal symmetry index that measures the three-dimensional (3D) volume difference between the corneal surfaces of fellow eyes for differentiating between normal and abnormal corneas, including early detection and prognosis of ectatic disorders such as keratoconus and Fuchs dystrophy.
1 . A method for early detection of eye disease comprising:
using a corneal topography device and integrated software to measure and store elevation data at a plurality of points on the patient's anterior and posterior corneal surfaces;
organize the elevation data for each cornea into a two-dimensional matrix where the center of the cornea is in the center of the data frame,
rotate the data for a first eye 180 degrees around the Y axis relative to a second eye, apply image registration,
subtract data on each corresponding corneal point, and
generate an elevation difference matrix showing the degree of symmetry or asymmetry between the patient's left and right eye corneal topography.
2 . The method of claim 1 , further comprising applying machine learning techniques to collected corneal topography data to develop and/or refine defined clusters for normal and various abnormal eye symmetries.
3 . The method of claim 1 , further comprising applying machine learning techniques to collected corneal topography data to improve image registration.
4 . A device comprising:
a rotating Scheimpflug camera configured to measure the elevation of a patient's two anterior corneas sequentially or simultaneously;
a computer processor;
and non-transitory computer readable media including computer readable instructions, which, when executed by the computer processor, causes the device to
measure and store elevation data at a plurality of points on the patient's anterior and posterior corneal surfaces;
organize the elevation data for each cornea into a two-dimensional matrix where the center of the cornea is in the center of the data frame,
rotate the data for a first eye 180 degrees around the Y axis relative to a second eye,
subtract data on each corresponding corneal point, and
generate an elevation difference matrix showing the degree of symmetry or asymmetry between the patient's left and right eye corneal topography.
5 . A method for early detection of eye disease, comprising:
using a corneal topography device and integrated software to
measure and store elevation data at a plurality of points on the patient's anterior and posterior corneal surfaces;
organize the elevation data for each cornea into a two-dimensional matrix where the center of the cornea is in the center of the data frame,
rotate the data for a first eye 180 degrees around the Y axis relative to a second eye,
apply image registration, aligning the matrices for each eye by matching their centers and corresponding points,
refine image registration by
translating positions along x, y and z axes to correct for discrepancies in centering,
rotating the matrices to account for differences in head orientation during imaging,
correct for angular misalignment due to head tilt in the sagittal or transverse planes,
perform a point-by-point subtraction between corresponding points of the two matrices, taking the absolute value of each elevation difference,
generate an elevation difference matrix showing the degree of symmetry or asymmetry between the patient's left and right eye corneal topography,
select a 4.0 mm-6.0 mm diameter zone at a center of the cornea,
determine the three-dimensional volume difference between the two corneal surfaces within the selected zone by calculating the average of all absolute elevation differences.
6 . A device comprising:
a rotating Scheimpflug camera configured to measure the elevation of a patient's two anterior corneas sequentially or simultaneously;
a computer processor;
and non-transitory computer readable media including computer readable instructions, which, when executed by the computer processor, causes the device to
measure and store elevation data at a plurality of points on the patient's anterior and posterior corneal surfaces;
organize the elevation data for each cornea into a two-dimensional matrix where the center of the cornea is in the center of the data frame,
rotate the data for a first eye 180 degrees around the Y axis relative to a second eye,
apply image registration, aligning the matrices for each eye by matching their centers and corresponding points,
refine image registration by
translating positions along x, y and z axes to correct for discrepancies in centering,
rotating the matrices to account for differences in head orientation during imaging,
correct for angular misalignment due to head tilt in the sagittal or transverse planes,
perform a point-by-point subtraction between corresponding points of the two matrices, taking the absolute value of each elevation difference,
generate an elevation difference matrix showing the degree of symmetry or asymmetry between the patient's left and right eye corneal topography,
select a 4.0 mm-6.0 mm diameter zone at a center of the cornea,
determine the three-dimensional volume difference between the two corneal surfaces within the selected zone by calculating the average of all absolute elevation differences.