IP Library › Patent Application 19281019
Patent Application
App. No. 19/281,019

SYNTHESIS OF KEY INTERMEDIATE OF KRAS G12C INHIBITOR COMPOUND

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Quick Facts
Patent No.
US None
App. No.
19/281,019
Abstract

The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure useful for the synthesis of compounds that target KRAS G12C mutations, such as

Claims (5)

1 . A process of preparing a compound of Formula (5M):

the method comprising:

mixing compound of Formula (4):

with a chiral acid to provide a mixture of compound of Formula (4) and the chiral acid; and

crystallizing the mixture of compound of Formula (4) and the chiral acid to provide a cocrystal compound of Formula (5M) and the chiral acid.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 7, 2025
From: PARSONS, ANDREW THOMAS; COCHRAN, BRIAN MCNEIL; POWAZINIK, WILLIAM, IV; CAPORINI, MARC ANTHONY
To: AMGEN INC.
Reel/Frame 072825/0375 →