Lumen Coating Method and Apparatus
A method for coating the lumen of a tube comprises the steps of inserting the distal opening of a tube into a first coating solution, drawing the first coating solution into the lumen of the tube, draining the first coating solution from the lumen leaving a film of the first coating solution on the lumen of the tube, and curing the first coating solution. This leaves a first coating on the lumen of the tube. A coating apparatus comprises a pallet, and one or more dip funnels. The pallet comprises a manifold and is configured to fluidically connect the manifold to one or more tubes. The one or more dip funnels are configured to hold a coating solution and are located below the pallet so that when the pallet is moved vertically, the one or more tubes are inserted into the dip funnels.
1 . A method for coating the lumen of a tube comprising the steps of:
inserting a masking tube in one end of the tube,
inserting the distal opening of the tube into a first coating solution,
drawing the first coating solution into the lumen of the tube,
draining the first coating solution from the lumen leaving a film of the first coating solution on the lumen of the tube,
curing the first coating solution, wherein the first coating solution comprises a mixture of polyaziridine and either polyurethane or polyacrylate.
2 . The method of claim 1 , wherein the step of drawing the first coating solution into the lumen of the tube, draws the first coating solution into the masking tube.
3 . The method of claim 1 , further comprising the steps of:
inserting at least a portion of the tube into the first coating solution before or simultaneous with the step of drawing the first coating solution into the lumen of the tube, and
before, during, or after draining the first coating solution from the lumen, removing a least a portion of the tube from the first coating solution leaving a film of the first coating solution on the outside surface of the tube.
4 . The method of claim 1 , further comprising the steps of:
inserting the distal opening of the tube into a second coating solution,
drawing the second coating solution into the lumen of the tube,
draining the second coating solution from the lumen leaving a film of the second coating solution on the lumen of the tube, and
curing the second coating solution.
5 . The method of claim 4 , wherein the step of drawing the second coating solution into the lumen of the tube, draws the second coating solution into the masking tube.
6 . The method of claim 4 , further comprising the steps of:
inserting at least a portion of the tube into the second coating solution before or simultaneous with the step of drawing the second coating solution into the lumen of the tube, and
before, during, or after draining the second coating solution from the lumen, removing a least a portion of the tube from the second coating solution leaving a film of the second coating solution on the outside surface of the tube.
7 . The method of claim 3 , further comprising the steps of:
inserting the distal opening of a tube into a second coating solution,
drawing the second coating solution into the lumen of the tube,
draining the second coating solution from the lumen leaving a film of the second coating solution on the lumen of the tube, and
curing the second coating solution.
8 . The method of claim 1 , wherein the masking tube has a length of between 5 mm and 10 cm.
9 . The method of claim 7 , further comprising the steps of:
inserting at least a portion of the tube into the second coating solution before or simultaneous with the step of drawing the second coating solution into the lumen of the tube, and
before, during, or after draining the second coating solution from the lumen, removing a least a portion of the tube from the second coating solution leaving a film of the second coating solution on the outside surface of the tube.
10 . The method of claim 1 , wherein the first coating solution is drained from the lumen by flowing a gas through the lumen.
11 . The method of claim 1 , further comprising the step of flowing a cleaning solution through the tube.
12 . The method of claim 1 , wherein the first coating solution additionally comprises a short chain alcohol.
13 . The method of claim 1 , wherein the first coating solution additionally comprises a zirconate or titanate compound.
14 . The method of claim 13 , wherein the zirconate compound comprises tetra (2,2 diallyloxymethyl)butyl zirconate; di(ditridecyl)phosphito zircanote; zirconium IV bis octanolato, cyclo (dioctyl) pyrophosphato-O, O, or combinations thereof.
15 . The method of claim 13 , wherein the titanate compound comprises teraisopropyl di(dioctyl)phosphito titanate; and titanium IV bis octanolato, cyclo (dioctyl) pyrophosphato-O, O, or combinations thereof.
16 . The method of claim 4 , wherein the second coating solution comprises polysaccharide and/or polyacrylic acid.
17 . The method of claim 4 , wherein the second coating solution comprises a crosslinker.
18 . The method of claim 1 , wherein the tube is a catheter.
19 . The method of claim 1 , wherein the polyaziridine comprises a cross liker selected from trimethylolpropane tris(2-methyl-1-aziridine propionate) (TMAZ), N,N′-(methylenedi-p-phenylene)bis(aziridine-1-carboxamide) (DAZ), trimethylolpropane bis(2-methyl-1-aziridine propionate), pentaerythritol bis(3-(1-aziridinyl) propionate, pentaerythritol tris(3-(1-aziridinyl) propionate (TAZ), and pentaerythritol tetrakis(3-(1-aziridinyl) propionate.
20 . The method of claim 1 , wherein the polyaziridine comprises a cross liker selected from trimethylolpropane tris(2-methyl-1-aziridine propionate) (TMAZ), N,N′-(methylenedi-p-phenylene)bis(aziridine-1-carboxamide) (DAZ), and pentaerythritol tris(3-(1-aziridinyl) propionate (TAZ).
21 . The method of claim 1 , wherein the polyaziridine comprises trimethylolpropane tris(2-methyl-1-aziridine propionate) (TMAZ).