IP Library › Patent Application 19290958
Patent Application
App. No. 19/290,958

Novel Systems, Methods, And Compositions For The Glycosylation Of Cannabinoid Compounds

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Patent No.
US None
App. No.
19/290,958
Abstract

The present invention relates generally to the identification novel UDP-glucosyltransferases enzymes having specific activity towards cannabinoid compounds. The present invention further relates generally to the use of novel UGT enzymes having specific activity towards cannabinoid compounds to generate water-soluble cannabinoid glycoside compounds.

Claims (12)

1 . A system for producing glycosylated cannabidiol (CBD) comprising:

a yeast cell culture, where the yeast cells express a heterologous nucleotide sequence, operably linked to a promoter, encoding a UDP-glucosyltransferases (UGT) according to the amino acid sequence SEQ ID NO. 8963, or a sequence having at least 95% sequence identity with SEQ ID NO. 8963; and

wherein CBD is introduced to the culture where the UGT glycosylates said CBD generating a CBD glycoside.

2 . The system of claim 1 , wherein the yeast is Picha pastoris.

3 . A system for producing glycosylated tetrahydrocannabinol (THC) comprising:

a yeast cell culture, where the yeast cells express a heterologous nucleotide sequence, operably linked to a promoter, encoding a UDP-glucosyltransferases (UGT) according to the amino acid sequence SEQ ID NO. 8963, or a sequence having at least 95% sequence identity with SEQ ID NO. 8963; and

wherein THC is introduced to the culture where the UGT glycosylates said THC generating a THC glycoside.

4 . The system of claim 3 , wherein the yeast is Picha pastoris.

5 . A system for producing a glycosylated cannabinoid comprising:

a yeast cell culture, where the yeast cells express a heterologous nucleotide sequence, operably linked to a promoter, encoding a UDP-glucosyltransferases (UGT) according to the amino acid sequence SEQ ID NO. 8963, or a sequence having at least 95% sequence identity with SEQ ID NO. 8963; and

wherein a mixture of cannabinoids selectively containing THC, CBD or both is introduced to the culture where the UGT glycosylates said THC and said CBD generating a THC and a CBD glycoside, respectively.

6 . The system of claim 5 , wherein the yeast is Picha pastoris.