MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USES THEREOF
The present invention provides compounds, compositions thereof, and methods of using the same.
1 . A method of eliciting a rapid-onset antidepressant activity in a patient in need thereof suffering from treatment-resistant depression, said method comprising administering to said patient a compound of formula I-90 or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable composition thereof:
2 - 19 . (canceled)
20 . The method of claim 1 , wherein said method further comprises administering to said patient an additional therapeutic agent or therapy.
21 . The method of claim 1 , wherein said rapid-onset antidepressant activity occurs within two weeks of administration of said compound of formula I-90 or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable composition thereof.
22 . The method of claim 1 , wherein said rapid-onset antidepressant activity occurs within one week of administration of said compound of formula I-90 or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable composition thereof.
23 . The method of claim 1 , wherein said rapid-onset antidepressant activity occurs within seven days of administration of said compound of formula I-90 or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable composition thereof.
24 . The method of claim 1 , wherein said rapid-onset antidepressant activity occurs within six days of administration of said compound of formula I-90 or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable composition thereof.
25 . The method of claim 1 , wherein the rapid-onset antidepressant activity occurs within seven days of administration of said compound of formula I-90 or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable composition thereof.
26 . The method of claim 1 , wherein said rapid-onset antidepressant activity occurs within five days of administration of said compound of formula I-90 or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable composition thereof.
27 . The method of claim 1 , wherein said rapid-onset antidepressant activity occurs within four days of administration of said compound of formula I-90 or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable composition thereof.
28 . The method of claim 1 , wherein said rapid-onset antidepressant activity occurs within three days of administration of said compound of formula I-90 or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable composition thereof.
29 . The method of claim 1 , wherein said rapid-onset antidepressant activity occurs within two days of administration of said compound of formula I-90 or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable composition thereof.
30 . The method of claim 1 , wherein said rapid-onset antidepressant activity occurs within one day of administration of said compound of formula I-90 or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable composition thereof.
31 . The method of claim 1 , wherein said rapid-onset antidepressant activity occurs within less than twenty-four hours of administration of said compound of formula I-90 or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable composition thereof.
32 . The method of claim 1 , wherein said rapid-onset antidepressant activity is both rapid-onset antidepressant activity and long-lasting, sustained antidepressant activity.
33 . The method of claim 32 , wherein said long-lasting, sustained antidepressant activity persists for at least twenty-four hours after administration of said compound of formula I-90 or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable composition thereof.
34 . The method of claim 32 , wherein said long-lasting, sustained antidepressant activity persists for longer than one day after administration of said compound of formula I-90 or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable composition thereof.
35 . The method of claim 32 , wherein said long-lasting, sustained antidepressant activity persists for at least two days after administration of said compound of formula I-90 or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable composition thereof.
36 . The method of claim 32 , wherein said long-lasting, sustained antidepressant activity persists for at least three days after administration of said compound of formula I-90 or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable composition thereof.
37 . The method of claim 32 , wherein said long-lasting, sustained antidepressant activity persists for at least four days after administration of said compound of formula I-90 or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable composition thereof.
38 . The method of claim 32 , wherein said long-lasting, sustained antidepressant activity persists for at least five days after administration of said compound of formula I-90 or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable composition thereof.